Search results for "live"

Inulin Derivatives Obtained Via Enhanced Microwave Synthesis for Nucleic Acid Based Drug Delivery

2015

A new class of therapeutic agents with a high potential for the treatment of different socially relevant human diseases is represented by Nucleic Acid Based Drugs (NABD), including small interfering RNAs (siRNA), decoy oligodeoxynucleotides (decoy ODN) and antisense oligonucleotides (ASOs). Although NABD can be engineered to be specifically directed against virtually any target, their susceptibility to nuclease degradation and the difficulty of delivery into target tissues severely limit their use in clinical practice and require the development of an appropriate nanostructured delivery system. For delivery of NABD, Inulin (Inu), a natural, water soluble and biocompatible polysaccharide, wa…

Cationic solid lipid nanoparticles complexed with genetic material for liver tumor treatment

2015

Concept Gene therapy is a growing field of medicine with great potential for the treatment of several diseases and it is based on the delivery of nucleic acids (DNA, RNA, etc.,) to specific cells. To achieve their therapeutic effects, the nucleic acids need to cross several biological barriers and be protected from the degradation by nucleases, present in biological fluids and intracellular compartments, to successfully gain access to their intracellular targets. To overcome these hurdles, it is necessary to deliver the genetic material with biocompatible carriers able to facilitate its translocation across the cell membranes and protect it from being degraded while circulating in the blood…

Silibin hepatoprotection occur via NFKB signaling inhibition in murine nonalcholic fatty liver disease

2009

Motions with Emotions? : A Phenomenological Approach to Understanding the Simulated Aliveness of a Robot Body

2019

This article examines how the interactive capabilities of companion robots, particularly their materiality and animate movements, appeal to human users and generate an image of aliveness. Building on Husserl’s phenomenological notion of a ‘double body’ and theories of emotions as affective responses, we develop a new understanding of the robots’ simulated aliveness. Analyzing empirical findings of a field study on the use of the robot Zora in care homes for older people, we suggest that the aliveness of companion robots is the result of a combination of four aspects: 1) material ingredients, 2) morphology, 3) animate movements guided by software programs and human operators as in Wizard of …

“Congratulations, you’re on TV!”: Middle-space performances of live tweeters during the FIFA World Cup

2018

Social television has transformed the traditional role of the television viewers by providing ‘ordinary people’ access to the public stage. This article describes how public access to television affected the dialogues of Finnish tweeters on Twitter during the massive media event of the FIFA World Cup. Through the lens of digital conversation analysis, the study shows how the media publicity of tweets changed the direction of the interaction between tweeters and transformed their roles vis-à-vis the television show, making one of them into a ‘media flasher’ and the others viewers of his or her performance. The publicity was constructed as important through noticings, congratulations, and com…

Microneedle-Based Delivery: An Overview of Current Applications and Trends

2020

Microneedle arrays (MNA) are considered as one of the most promising resources to achieve systemic effects by transdermal delivery of drugs. They are designed as a minimally invasive, painless system which can bypass the stratum corneum, overcoming the potential drawbacks of subcutaneous injections and other transdermal delivery systems such as chemical enhancers, nano and microparticles, or physical treatments. As a trendy field in pharmaceutical and biomedical research, its applications are constantly evolving, even though they are based on very well-established techniques. The number of molecules administered by MNA are also increasing, with insulin and vaccines administration being the …

A fluorescence study of the loading and time stability of doxorubicin in sodium cholate/PEO-PPO-PEO triblock copolymer mixed micelles

2019

Abstract Hypothesis Doxorubicin hydrochloride (DX) is one of the most powerful anticancer agents though its clinical use is impaired by severe undesired side effects. DX encapsulation in nanocarrier systems has been introduced as a mean to reduce its toxicity. Micelles of the nonionic triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) (PEO-PPO-PEO), are very promising carrier systems. The positive charge of DX confines the drug to the hydrophilic corona region of the micelles. The use of mixed micelles of PEO-PPO-PEO copolymers and a negatively charged bile salt should favour the solubilization of DX in the apolar core region of the micelles. Experiments We st…

Aristóteles entre doxografía y biografía: sobre Diógenes Laercio V 31

2019

Se pretende llamar la atención sobre un par de frases que aparecen justo hacia la mitad de la controvertida doxografía de Aristóteles que se puede leer en las Vidas y doctrinas de los filósofos más ilustres de Diógenes Laercio V 31, y que desde luego no corresponden a ningún sistema doxográfico conocido. Como sucede no pocas veces en la obra laerciana, la misma apreciación sobre si el filósofo debe o no enamorarse y contraer matrimonio se repite idéntica en otras doxografías completamente distintas: la cirenaica (DL II 91), la estoica (DL VII 129) y la epicúrea (DL X 118). Cabe plantearse, pues, el origen de este interés, en varias doxografías, por la vida sentimental, podríamos decir, de l…

EDM and Ecstasy: the lived experiences of electronic dance music festival attendees

2017

Attendance at large-scale music festivals has captivated a global interest in these spectacular experiences, yet little is known about the lasting benefits and personal changes individuals incur following this event. This study aims to provide a comprehensive exploration of the lived experiences of individuals who attended a multi-day electronic dance music festival. The present study was primarily interested in the perceived beneficial changes within the individual, following their festival experience. We investigated if first-time festival attendees perceived changes differed to those of returning individuals. Semi-structured qualitative interviews were used to collect data from 12 indivi…

Do social networks bridge political divides? The analysis of VKontakte social network communication in Ukraine

2014

New electronic forms of political communication have become increasingly popular in countries with weak democratic institutions. The effectiveness of these new forms of association in altering political behavior, however, remains uncertain even in developed democratic regimes. This paper investigates connections between regional variation in electoral behavior and regional distribution of electronic social networks in the case of Ukraine's polarized and institutionally unstable democracy. Our analysis of online networks shows that, somewhat contrary to conventional wisdom, electronic communication does not bridge political divides. This finding casts doubt on the effectiveness of online for…