Search results for "loading"
showing 10 items of 233 documents
PIRACY REVISITED: EXPLORING MUSIC USERS IN THE AGE OF TECHNOLOGY DEPENDENCY
2019
This paper empirically investigates and characterizes users of recorded music, both downloaders and purchasers. To this end we analyse the role of the variables defining the different segments of music users. In doing so, we have considered two main traits influencing the use of music. First, objective variables such as demographics, music consumption habits, music genres and technology. Second, subjective variables such as motives and attitudes towards piracy. Using data from a personal survey, subsequent latent class and fuzzy analyses show that while the former characteristics are relevant in those getting music for free from the Internet, the latter don´t pay any special part, contrary …
Loading profile of topotecan into polyvinyl alcohol microspheres (DC Bead™) over a 7-day period
2011
Purpose: DC Bead™ is successfully used for chemoembolization of various liver cancers. The purpose of this study was todetermine the loading capacity of the semi-synthetic topoisomerase-1 inhibitor topotecan into the DC Bead™ microspheres under static or agitated conditions and to assess the physicochemical stability over a period of 7 days. Methods: Commercially available topotecan hydrochloride powder (Hycamtin®) was reconstituted with water for injection to yield a nominal concentration of 1 mg/mL topotecan. Polyvinyl alcohol (PVA)-based microspheres (DC Bead™, 300–500 µm, 2 mL/vial) were mixed with 4 mL of the reconstituted topotecan solution. Vials were stored light protected at room …
Coalition: Advocacy for prospective clinical trials to test the post-exposure potential of hydroxychloroquine against COVID-19
2020
Our coalition of public health experts, doctors, and scientists worldwide want to draw attention to the need for high-quality evaluation protocols of the potential beneficial effect of hydroxychloroquine (HCQ) as a post-exposure drug for exposed people. In the absence of an approved, recognized effective pre or post-exposure prophylactic drug or vaccine for COVID-19, nor of any approved and validated therapeutic drug, coupled with social and political pressure raised by publicity both regarding the potential beneficial effect of hydroxychloroquine (HCQ) as well as potential risks from HCQ, we urge the immediate proper clinical trials. Specifically, we mean using HCQ for post-exposure of peo…
General Diagnosis and Medical Evaluation
2019
Current literature does not contribute to a high level of evidence regarding possible indications for immediate loading. A great variety of exclusion criteria for immediate loading of dental implants are used in different studies. However, the reported criteria are similar to those chosen for conventional loading of dental implants. Despite its several clinical advantages, the immediate loading protocol should be performed respecting a rigorous preliminary diagnostic algorithm. Primary indication for immediate implant loading is certainly patients’ desire to reduce the overall treatment time. Additionally, several psychological factors, related to the preservation of functional and esthetic…
A full body musculoskeletal model based on flexible multibody simulation approach utilised in bone strain analysis during human locomotion
2011
Load-induced strains applied to bone can stimulate its development and adaptation. In order to quantify the incident strains within the skeleton, in vivo implementation of strain gauges on the surfaces of bone is typically used. However, in vivo strain measurements require invasive methodology that is challenging and limited to certain regions of superficial bones only such as the anterior surface of the tibia. Based on our previous study [Al Nazer et al. (2008) J Biomech. 41:1036-1043], an alternative numerical approach to analyse in vivo strains based on the flexible multibody simulation approach was proposed. The purpose of this study was to extend the idea of using the flexible multibod…
Dynamic shakedown of structures under repeated seismic loads
1995
Elastic, perfectly plastic structures are considered under the action of repeated short-duration exitations of seismic type acting in an unknown time sequence, but belonging to a given polyhedral excitation domain. The basic excitations (vertices of the polyhedron) are chosen as discrete-spectrum waves each with frequencies coincident with the first natural frequencies of the structure, and amplitudes related to the ground features and earthquake intensity (according to the Kanai and Tajimi filter model) in such a way that every admissible excitation-obtained as a linear convex combination of the basic ones-has a maximum power not exceeding a given value. In the framework of unrestricted dy…
Fatigue life under non-Gaussian random loading from various models
2004
Fatigue test results on the 10HNAP steel under constant amplitude and random loading with non-Gaussian probability distribution function, zero mean value and wide-band frequency spectrum have been used to compare the life time estimation of the models proposed by Bannantine, Fatemi–Socie, Socie, Wang–Brown, Morel and Łagoda–Macha. Except the Morel proposal which accumulates damage step by step with a proper ethodology, all the other models use a cycle counting method. The rainflow algorithm is used to extract cycles from random histories of damage parameters in time domain. In the last model, where a strain energy density parameter is employed, additionally spectral method is evaluated for …
A novel frequency domain method for predicting fatigue crack growth under wide band random loading
2007
This work deals with the evaluation of the fatigue crack growth rate of structural components subjected to uniaxial Gaussian stationary wide band random loading. In detail, a new frequency domain method that allows the user to estimate the expected crack growth rate directly from the PSD data is proposed. Using a stochastic mean function properly, introduced and described by simple closed form relationships implemented by systematic numerical simulations of a high number of wide band random processes, the proposed method permits to avoid the onerous time domain simulations and provides in general crack growth rate predictions in a good accordance with the so-called time domain method. Pract…
A GRASP algorithm for the container stowage slot planning problem
2016
This work presents a generalization of the Slot Planning Problem which raises when the liner shipping industry needs to plan the placement of containers within a vessel (stowage planning). State-of-the-art stowage planning relies on a heuristic decomposition where containers are first distributed in clusters along the vessel. For each of those clusters a specific position for each container must be found. Compared to previous studies, we have introduced two new features: the explicit handling of rolled out containers and the inclusion of separations rules for dangerous cargo. We present a novel integer programming formulation and a Greedy Randomized Adaptive Search Procedure (GRASP) to solv…
Flexural behaviour of glass panels under dead load and uniform lateral pressure
2013
Abstract In the present paper the experimental results relative to flexural tests on out-of-plane loaded large scale panels made of laminated structural glass are presented and discussed. Glass panels are parts of the structural facade of the Fontanarossa International Airport of Catania (Italy). Panels are mounted on a rigid testing frame and loaded with an uniformly distributed lateral pressure. Two different kinds of tests were carried-out, cyclic and monotonic, able to reproduce the serviceability and the ultimate conditions of the glass panels when subjected to the coupled effects of dead load and horizontal forces, the latter reproducing the wind action. Results obtained focused the h…