Search results for "loma"

Linfoma angiocéntrico localizado en paladar

2001

Resumen Los linfomas angiocentricos son neoplasias muy poco frecuentes en nuestra area geografica. Suelen presentarse en la region oronasal como lesiones de tipo necrotico, en concreto en la zona mediofacial, con una evolucion rapida y un pronostico sombrio. Inmunohistoquimicamente se ha detectado que en estas neoplasias las celulas malignas corresponden a linfocitos T. Ademas estudios recientes apoyan la hipotesis del posible papel del virus de Epstein-Barr como posible factor etiologico. Presentamos en este articulo el caso clinico de un hombre de 67 anos con una lesion ulcerada en el paladar, de corto tiempo de evolucion y que tras estudio histopatologico e inmunohistoquimico se confirmo…

Études scientifiques et marché du travail : éléments de réflexion sur la crise des formations en sciences

2007

Student disaffection towards sciences, most evident in pure science undergraduates, is causing increasing concern for the future of scientific training in France. If access to employment deteriorates more for science graduates than for graduates in other disciplines, science graduates will have a distinct advantage in terms of earnings and employment status, when the economic situation becomes less favourable. Within sciences, graduates of pure sciences have a more difficult transition from education to employment than those from applied sciences. Yet graduates from both disciplines compete for the same job in the private sector with pure science graduates receiving lower wages. The “crisis…

Proliferative verrucous vs conventional leukoplakia: no significantly increased risk of HPV infection

2004

Proliferative verrucous leukoplakia (PVL) is a very aggressive form of oral leukoplakia (OL) with high morbidity and mortality rates, hypothesised to be linked to HPV infection. This study aimed to determine the presence of HPV DNA in PVL in comparison with OL, and in relation to social-demographical variables (age, gender, smoking and drinking habits) in an Italian multi-centric hospital-based study. The study group consisted of 58 cases of PVL and 90 cases of OL as controls (47 homogeneous (H) and 43 non-homogeneous (non-H) form), both recruited from four Italian cohorts. HPV DNA was identified in exfoliated mucosal cells by nested PCR (nPCR) with MY09/MY11 and GP5+/GP6+ primer pairs and …

Tēvu iesaiste bērnu aprūpē un vecāku kompetences izjūta zīdaiņu tēviem.

2019

Pētījuma mērķis bija izpētīt tēvu iesaistes bērnu aprūpē saistību ar kompetences izjūtu zīdaiņu tēviem. Pētījuma jautājums bija: Vai tēva iesaiste bērna aprūpē ir saistīta ar kompetences izjūtu zīdaiņu tēviem? Pētījumā piedalījās 131 respondents, vecumā no 21 līdz 55 gadiem (M = 32,4, SD = 5,77.), kuram ir bērns zīdaiņa vecumā līdz vienam gadam. 89 tēviem zīdaiņa vecuma bērns bija pirmais bērns ģimenē. Mērījumiem tika izmantoti sekojoši instrumenti: Vecāku kompetences izjūtas skala (Parenting sense of competence scale, Johnston & Mash, 1989) un Tēvu iesaistes zīdaiņu aprūpē pašnovērtējuma skala (PIWIS, Paternal Involvement with infants Scale, Singley, Cole, Hammer, Molloy, Rowell, Isacco, 2…

Inhibition by cellular vacuolar ATPase impairs human papillomavirus uncoating and infection.

2014

ABSTRACT Several viruses, including human papillomaviruses, depend on endosomal acidification for successful infection. Hence, the multisubunit enzyme vacuolar ATPase (V-ATPase), which is mainly responsible for endosome acidification in the cell, represents an attractive target for antiviral strategies. In the present study, we show that V-ATPase is required for human papillomavirus (HPV) infection and that uncoating/disassembly but not endocytosis is affected by V-ATPase inhibition. The infection inhibitory potencies of saliphenylhalamide, a proven V-ATPase inhibitor, and its derivatives, as well as those of other V-ATPase inhibitors, were analyzed on different HPV types in relevant cell l…

Analysis of treatment efficacy in the GEM-CESAR trial for high-risk smoldering multiple myeloma patients: Comparison between the standard and IMWG MR…

2020

8512 Background: The GEM-CESAR trial is a potentially curative strategy for high-risk smoldering multiple myeloma (HRsMM) patients (pts) in which the primary endpoint is the achievement of sustained minimal residual disease (MRD) negativity in the bone marrow (BM) by next generation flow (NGF). The value of BM MRD assessment in MM is proven, but alternative, non-invasive methods, accurately reflecting disease burden are needed. Methods: Pts received six 4-week cycles of KRd as induction (K:36mg/m2 twice weekly, R: lenalidomide 25mg po od days 1-21 and d:dexamethasone 40mg po weekly) followed by melphalan 200mg/m2, two further cycles of KRd as consolidation and up to 2 years of Rd (R:10mg/d…

INCIDENTALOMA: INDICAZIONI E LIMITI DELLA TERAPIA CHIRURGICA

2008

Old and new immunophenotypic markers in multiple myeloma for discrimination of responding and relapsing patients: The importance of "normal" residual…

2014

Background Multiple myeloma is an incurable disease characterized by proliferation of clonal malignant plasma cells (CPCs), which can be immunophenotypically distinguished from polyclonal plasma cells (PPCs) by multiparameter flow cytometry (MFC). The utility of PPCs analysis in detecting prognostic and predictive information is still a matter of debate. Methods: we tested the ability of 11 MFC markers in detecting differences in the immunophenotype of CPCs and PPCs among patients in various disease stages; we verified if these markers could be associated with disease stage/response to therapy despite the role of clinical parameters. Results: significant changes in the expression of markers…

Changes in polypeptide profiles of two pea genotypes inoculated with the arbuscular mycorrhizal fungus Glomus mosseae

1994

The symbiotic interaction between pea roots ('Pisum sativum' L.) and the endomycorrhizal fungus 'Glomus mosseae' should lead to specific gene expression of both symbionts. In order to detect symbiosis-related proteins (endomycorrhizins), we used two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) after phenolic extraction of total soluble proteins. Furthermore, to better characterize the molecular changes after fungal infection, two pea genotypes available in our laboratory were used: cv. Frisson (myc⁺) and an isogenic mycorrhiza-resistant mutant (myc⁻). The latter prevents intraradical fungal development. Several differences were observed in polypeptide patterns of silver-stained …

N transport in the Hebeloma cylindrosporum – Pinus pinaster ectomycorrhizal association

2007

International audience; Studies of nitrogen metabolism in ectomycorrhizas have demonstrated that the fungal symbiont plays a fully integrated role in plant root metabolism and participates actively in the assimilation and transfer of newly absorbed nitrogen compounds by transferring amino acids. In symbiotic associations, such as mycorrhizas, location of the symbiosis ensures that mycelial growth of the fungus into soil provides access to nutrients of the soil solution. Changes in the distribution and activity of membrane-bound transport proteins in response to symbiotic interactions need to be investigated. In recent years several genes from H. cylindrosporum and P. pinaster, putatively in…