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RESEARCH PRODUCT
Young Adult and Usual Adult Body Mass Index and Multiple Myeloma Risk: A Pooled Analysis in the International Multiple Myeloma Consortium (IMMC)
John J. SpinelliGraham G. GilesGraham G. GilesParveen BhattiParveen BhattiAlexandra NietersDennis D. WeisenburgerAnneclaire J. De RoosLenka ForetovaPaolo BoffettaMark P. PurdueNikolaus BeckerNicola J. CampBrian C.-h. ChiuMarc MaynadiéGuido TricotSilvia De SanjoséPier Luigi CoccoDalsu BarisYawei ZhangVeronique Benhaim-luzonKirsten B. MoysichLaura CostasAnthony StainesElizabeth E. BrownWendy CozenPaul BrennanBrenda M. BirmannGabriella Andreottisubject
0301 basic medicineMaleobesityprocedureEpidemiologygroups by ageOverweightcancer riskBody Mass Index[ SDV.CAN ] Life Sciences [q-bio]/Cancer0302 clinical medicinestudy designRisk Factorsmiddle agedYoung adultrisk factor AdultMultiple myeloma2. Zero hungereducation.field_of_studyanthropometryadultrisk assessment3. Good healthmultiple myelomafemaleOncologypriority journal030220 oncology & carcinogenesisyoung adultmedicine.symptomCase-Control Studiemedicine.medical_specialtymultivariate logistic regression analysiPopulation[SDV.CAN]Life Sciences [q-bio]/CancerArticle03 medical and health sciencesInternal medicinemedicineHumanshumaneducationAgedbusiness.industryCase-control studyAnthropometrycase control studymedicine.diseaseConfidence interval030104 developmental biologyEndocrinologyCase-Control StudiespathologybusinessBody mass indexbody madescription
AbstractBackground: Multiple myeloma risk increases with higher adult body mass index (BMI). Emerging evidence also supports an association of young adult BMI with multiple myeloma. We undertook a pooled analysis of eight case–control studies to further evaluate anthropometric multiple myeloma risk factors, including young adult BMI.Methods: We conducted multivariable logistic regression analysis of usual adult anthropometric measures of 2,318 multiple myeloma cases and 9,609 controls, and of young adult BMI (age 25 or 30 years) for 1,164 cases and 3,629 controls.Results: In the pooled sample, multiple myeloma risk was positively associated with usual adult BMI; risk increased 9% per 5-kg/m2 increase in BMI [OR, 1.09; 95% confidence interval (CI), 1.04–1.14; P = 0.007]. We observed significant heterogeneity by study design (P = 0.04), noting the BMI–multiple myeloma association only for population-based studies (Ptrend = 0.0003). Young adult BMI was also positively associated with multiple myeloma (per 5-kg/m2; OR, 1.2; 95% CI, 1.1–1.3; P = 0.0002). Furthermore, we observed strong evidence of interaction between younger and usual adult BMI (Pinteraction <0.0001); we noted statistically significant associations with multiple myeloma for persons overweight (25–<30 kg/m2) or obese (30+ kg/m2) in both younger and usual adulthood (vs. individuals consistently <25 kg/m2), but not for those overweight or obese at only one time period.Conclusions: BMI-associated increases in multiple myeloma risk were highest for individuals who were overweight or obese throughout adulthood.Impact: These findings provide the strongest evidence to date that earlier and later adult BMI may increase multiple myeloma risk and suggest that healthy BMI maintenance throughout life may confer an added benefit of multiple myeloma prevention. Cancer Epidemiol Biomarkers Prev; 26(6); 876–85. ©2017 AACR.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-06-01 |