Search results for "long term"

showing 10 items of 203 documents

Host-directed therapies for COVID-19

2021

Purpose of review Severe acute respiratory syndrome coronavirus-2-induced hyperinflammation is a major cause of death or end-organ dysfunction in COVID-19 patients. We review adjunct host-directed therapies (HDTs) for COVID-19 management. Recent findings The use of umbilical cord-derived mesenchymal stem cells as HDT for COVID-19 has been shown to be safe in phase 1 and 2 trials. Trials of anti-interleukin-6 receptor antibodies show promising mortality benefit in hospitalized COVID-19 patients. Repurposed drugs and monoclonal antibodies targeting specific cytokines acting on different aspects of the pro- and anti-inflammatory cascades are under evaluation. Summary A range of HDTs shows prom…

InflammationPulmonary and Respiratory Medicine2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)SARS-CoV-2medicine.drug_classbusiness.industryMesenchymal stem cellCOVID-19InflammationLong term disabilityMesenchymal Stem Cell TransplantationBioinformaticsMonoclonal antibodymedicineHumansImmunologic FactorsIn patientMolecular Targeted Therapymedicine.symptombusinessCause of deathCurrent Opinion in Pulmonary Medicine
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Ex post-facto study of long-term stress in a sample of adoptees

2015

In this work we study the impact of relinquishment and the adoption process in posttraumatic symptoms and stressful life events in a group of 55 adults that were adopted as children after the Spanish Civil War (1936-1939). The effects of institutionalization, maltreatment and traumatic revelation of the adopted status have also been studied. No significant differences were found between institutionalized and non-institutionalized adoptees in posttraumatic symptomatology and stressful life events frequency. However, maltreated adoptees scored significantly higher in intrusion, arousal and stressful life events frequency than non-maltreated. Similar differences were found in the comparison be…

Institucionalización050103 clinical psychologymedicine.medical_specialtyStressful life eventsInstitutionalisationlcsh:BF1-990Posttraumatic symptomatology050109 social psychologyArousalIntrusionAdoptionMaltreatmentmedicine0501 psychology and cognitive sciencesrevelación traumáticaTraumatic revelationPsychiatryGeneral PsychologyAdopciónMaltrato05 social sciencesLife eventsAcontecimientos vitales estresantesInstitutionalizationsintomatología postraumáticalcsh:PsychologyLong term stressPsychologyAnales de Psicología
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Arterio-venous malformations in childhood: Clinical presentation, results after operative treatment and long-term follow-up

1989

In a series of 182 arterio-venous malformations (AVM) recently published [8] we found 33 children aged 1 to 16 years. In 28 cases, the admitting condition was hemorrhage. For 31 AVMs total excision was possible. We observed one postoperative death accounting for a mortality of 3%. All children but two were followed-up by personal examination. Two were not able to work due to severe neurological deficits and seven had not been able to get into their intended occupation.

Intracranial Arteriovenous MalformationsMalemedicine.medical_specialtyAdolescentLong term follow upPostoperative deathmedicineHumansChildCerebral Hemorrhagemedicine.diagnostic_testbusiness.industryInfantArteriovenous malformationGeneral Medicinemedicine.diseaseSurgeryEl NiñoChild PreschoolAngiographyFemaleSurgeryNeurology (clinical)NeurosurgeryEpileptic seizurePresentation (obstetrics)medicine.symptombusinessNeurosurgical Review
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Early and midterm outcomes of bioresorbable vascular scaffolds for ostial coronary lesions: insights from the GHOST-EU registry.

2016

Aims: We aimed to investigate the outcomes of bioresorbable vascular scaffolds (BVS) in coronary ostial lesions. Ostial lesions represent a challenging angiographic subset, with higher event rates compared with non-ostial lesions. BVS might be associated with advantages over the long term, but their safety in this setting remains to be explored. Methods and results: Procedural and 12-month follow-up data from consecutive patients treated with BVS for lesions located at the ostium of the right (RCA), left anterior (LAD) or circumflex (LCX) coronary in 11 European centres were collected. The primary device-oriented endpoint was defined as a combination of cardiovascular death, target vessel m…

LCX (29Target lesionMale52%). Patients presenting with ostial lesions did not differ from the remaining cohort except for a higher incidence of prior revascularisation. Predilation was performed in 97% of the lesions (vs. 96% in non-ostialp= 0.035)medicine.medical_treatmentMyocardial Infarction304 patients with a mean age of 62 +/- 11years. There were 90 ostial lesions (5.8%) in 84 patients (6.4%) located at the ostial RCA (14Coronary Artery Disease030204 cardiovascular system & hematologyCoronary artery diseasebut their safety in this setting remains to be explored. Methods and results: Procedural and 12-month follow-up data from consecutive patients treated with BVS for lesions located at the ostium of the right (RCA)0302 clinical medicineAbsorbable Implants030212 general & internal medicineMyocardial infarctionCircumflexRegistriesTissue Scaffolds32%)Drug-Eluting StentsMiddle AgedThrombosisCoronary VesselsAims: We aimed to investigate the outcomes of bioresorbable vascular scaffolds (BVS) in coronary ostial lesions. Ostial lesions represent a challenging angiographic subset with higher event rates compared with non-ostial lesions. BVS might be associated with advantages over the long term but their safety in this setting remains to be explored. Methods and results: Procedural and 12-month follow-up data from consecutive patients treated with BVS for lesions located at the ostium of the right (RCA) left anterior (LAD) or circumflex (LCX) coronary in 11 European centres were collected. The primary device-oriented endpoint was defined as a combination of cardiovascular death target vessel myocardial infarction or target lesion revascularisation. The database included a total of 1549 lesions in 1304 patients with a mean age of 62 +/- 11years. There were 90 ostial lesions (5.8%) in 84 patients (6.4%) located at the ostial RCA (14; 16%) LCX (29; 32%) or LAD (47; 52%). Patients presenting with ostial lesions did not differ from the remaining cohort except for a higher incidence of prior revascularisation. Predilation was performed in 97% of the lesions (vs. 96% in non-ostial p= 0.618) post-dilation in 43% (versus 58% in the non-ostial group p= 0.008). At quantitative coronary angiography treatment of ostial lesions was associated with higher residual stenosis (30% [23-41] vs. 26% [20-37] p= 0.035) but no difference in minimum lumen diameter existed (p= 0.447). Follow-up data were available at 385 [362-465] days. The 12-month Kaplan-Meier estimated rates of scaffold thrombosis were 4.9% and 2.0% (ostial and non-ostial lesion groups respectively log-rank p= 0.005). The device-oriented composite endpoint occurred respectively in 12.6% and 4.6% at 12 months (log-rank p= 0.001). Treatment of ostial lesions was an independent predictor of this endpoint (p= 0.0025 HR 2.65 [1.41-4.97]).OstiumAims: We aimed to investigate the outcomes of bioresorbable vascular scaffolds (BVS) in coronary ostial lesions. Ostial lesions represent a challenging angiographic subsetTreatment Outcomein 12.6% and 4.6% at 12 months (log-rank p= 0.001). Treatment of ostial lesions was an independent predictor of this endpoint (p= 0.0025CardiologyFemale549 lesions in 1medicine.symptomCardiology and Cardiovascular MedicineAdultpost-dilation in 43% (versus 58% in the non-ostial groupmedicine.medical_specialtyor LAD (47HR 2.65 [1.41-4.97])but no difference in minimum lumen diameter existed (p= 0.447). Follow-up data were available at 385 [362-465] days. The 12-month Kaplan-Meier estimated rates of scaffold thrombosis were 4.9% and 2.0% (ostial and non-ostial lesion groupsrespectivelyLesion03 medical and health sciencesPercutaneous Coronary Interventionwith higher event rates compared with non-ostial lesions. BVS might be associated with advantages over the long termleft anterior (LAD) or circumflex (LCX) coronary in 11 European centres were collected. The primary device-oriented endpoint was defined as a combination of cardiovascular deathInternal medicinemedicineHumanstarget vessel myocardial infarction or target lesion revascularisation. The database included a total of 1Agedp= 0.008). At quantitative coronary angiographybusiness.industryPercutaneous coronary interventionp= 0.618)treatment of ostial lesions was associated with higher residual stenosis (30% [23-41] vs. 26% [20-37]log-rank p= 0.005). The device-oriented composite endpoint occurredmedicine.diseaseSurgery16%)businessEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
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Using NASA'S Long Term Data Record version 3 for the monitoring of land surface vegetation

2011

Numerous datasets have been made available for the observation of our planet from space. The aim of this work is the observation of changes in vegetation, through the use of a recent remote sensing dataset, NASA's Long Term Data Record (LTDR). Several authors have pointed out that vegetation monitoring benefits of the simultaneous use of Normalized Difference Vegetation Index (NDVI) and land surface temperature (LST). Therefore, this work presents the procedure developed to monitor vegetation with the LTDR dataset, using both NDVI and LST parameters. This procedure includes data preprocessing (estimation of NDVI and LST, orbital drift correction, atmospherically contaminated data reconstruc…

Land surface temperatureRemote sensing (archaeology)Data reconstructionLong term dataEnvironmental scienceVegetationData pre-processingTime seriesNormalized Difference Vegetation IndexRemote sensing2011 6th International Workshop on the Analysis of Multi-temporal Remote Sensing Images (Multi-Temp)
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980nm laser for difficult-to-treat basal cell carcinoma

2013

Abstract Begin basal cell carcinoma (BCC) is most common skin cancer over the world. There are around 20 modalities for BCC treatment. Laser surgery is uncommon option. We demonstrate our long term follow up results. Aim:To evaluate long term efficacy of a 980nm diode laser for the difficult-to-treat basal cell carcinoma. Materials and Methods: 167 patients with 173 basal cell carcinoma on the nose were treated with a 980 nm diode laser from May 1999 till May 2005 at Latvian Oncology center. All tumors were morphologically confirmed. 156 patients were followed for more than 5 years. Results: The lowest recurrence rate was observed in cases of superficial BCC, diameter<6mm; bet the highes…

Laser surgerymedicine.medical_specialtyintegumentary systembusiness.industryLong term follow upmedicine.medical_treatmentPhotodynamic therapymedicine.diseaseLaserDermatologylaw.inventionmedicine.anatomical_structurelawmedicineBasal cell carcinomaSkin cancerbusinessLaser beamsNose
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Long-term course of chronic hepatitis C in children: from viral clearance to end-stage liver disease.

2008

Background & Aims: The natural course of chronic hepatitis C (CHC) in children is not well understood. The aim of this study was to assess the long-term course of CHC in a large sample of otherwise healthy children. Methods: From 1990 to 2005, 504 consecutive antihepatitis C virus (HCV)-positive children were enrolled at 12 centers of a national observatory and were followed up retrospectively/prospectively. Results: Putative exposure was perinatal in 283 (56.2%) cases, parenteral in 158 (31.3%), and unknown in 63 (12.5%). At baseline, 477 (94.6%) cases were HCV RNA seropositive, 118 (24.7%) of which were treated with standard interferon α. Ten years after putative exposure, the outcome in …

Liver CirrhosisMaleTime FactorsHepacivirusHepacivirusChronic hepatitis CGastroenterologyLiver diseaseViralProspective StudiesChronicProspective cohort studyChildChildrenchronic epatitis C; long term course; childrenbiologyHazard ratioGastroenterologyHepatitis CViral LoadHepatitis CTreatment OutcomeItalyChild PreschoolHCVDisease ProgressionRNA ViralFemaleViral loadmedicine.medical_specialtyAdolescentGenotypeAlpha interferonSocio-culturaleViremiaAntiviral AgentsRisk AssessmentHEPATITISInternal medicinemedicineHumansViremiaAdolescent; Antiviral Agents; Child; Child Preschool; Disease Progression; Female; Genotype; Hepatitis C Chronic; Humans; Infant; Interferon-alpha; Italy; Liver Cirrhosis; Male; Proportional Hazards Models; Prospective Studies; RNA Viral; Retrospective Studies; Risk Assessment; Time Factors; Treatment Outcome; Viral Load; Viremia; Hepacivirus; GastroenterologyPreschoolProportional Hazards ModelsRetrospective StudiesHepatologybusiness.industryLong-term courseInfantInterferon-alphaHepatitis C Chronicbiology.organism_classificationmedicine.diseaseImmunologyRNAbusinessGastroenterology
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Anterior/Apical single incision mesh (Elevate™): Surgical experience, anatomical and functional results, and long-term complications

2021

Abstract Objective Pelvic organ prolapse is a common condition among post-menopausal women, and surgery is often the standard treatment proposed. Native tissue vaginal surgery is burdened by a high rate of recurrence, and mesh vaginal surgery has become current practice. The purpose of this study was to evaluate the safety and the effectiveness of the vaginal kit Anterior/Apical single incision mesh Elevate™ for the correction of anterior and apical compartment prolapse. Study design Data of patients with symptomatic anterior vaginal prolapse stage ≥ II, receiving mesh repair with the Anterior/Apical Elevate single incision system between January 2010 and January 2015 were retrieved. Prolap…

Long term complicationsmedicine.medical_specialtyUrinary Incontinence StressMesh vaginal surgeryUrinary incontinenceUrinary incontinenceUrogynecologyPelvic Organ ProlapseUrogynecology03 medical and health sciences0302 clinical medicineGynecologic Surgical ProceduresMedicineHumans030212 general & internal medicinePelvic organ030219 obstetrics & reproductive medicineUrinary bladderbusiness.industryUrinary retentionStandard treatmentObstetrics and GynecologySurgical MeshSurgerymedicine.anatomical_structureTreatment OutcomeUtero-vaginal prolapseReproductive MedicineSingle incisionVaginaFemalemedicine.symptombusinessFollow-Up Studies
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Long term prognosis of patients with cardiac syndrome X: data from the Italian Registry of Syndrome X (RISX)

2009

Long term prognosis of patients with cardiac syndrome X: data from the Italian Registry of Syndrome X (RISX)

Long term prognosis of patients with cardiac syndrome X: data from the Italian Registry of Syndrome X (RISX)
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On the long-term response of elastic-perfectly plastic solids to dynamic cyclic loads

1992

It is shown that the long-term response of an elastic-perfectly plastic solid subjected to dynamic actions cyclically varying in time is characterized by stresses, plastic strain rates and velocities that are all periodic with the same period of the external actions, and are in perfect analogy with the quasi-static case; on the other hand, plastic strains and displacements are in general nonperiodic (except in case of alternating plasticity) and may increase indefinitely (except when elastic or plastic shakedown occurs). Besides, the work performed by the external actions in the steady cycle equals the work performed by the elastic stresses (i.e. pertaining to the elastic response of the bo…

Long term responseWork (thermodynamics)Materials scienceQuantitative Biology::Neurons and CognitionMechanics of MaterialsStructural mechanicsPlastic bendingMechanical EngineeringLevy–Mises equationsMechanicsPlasticityCondensed Matter PhysicsShakedownMeccanica
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