6533b7cffe1ef96bd12585ef
RESEARCH PRODUCT
Long-term course of chronic hepatitis C in children: from viral clearance to end-stage liver disease.
Bortolotti F.Cammà C.Cabibbo G.Zancan L.Indolfi G.Giacchino R.Marcellini M.Marazzi Mg:Barbera C.Maggiore G.Vajiro P.Bartolacci S.Balli F.Maccabruni A.Guido M.The Italian Observatory For Hcv InfectionHepatitis C. In ChildrenGabriella Verucchisubject
Liver CirrhosisMaleTime FactorsHepacivirusHepacivirusChronic hepatitis CGastroenterologyLiver diseaseViralProspective StudiesChronicProspective cohort studyChildChildrenchronic epatitis C; long term course; childrenbiologyHazard ratioGastroenterologyHepatitis CViral LoadHepatitis CTreatment OutcomeItalyChild PreschoolHCVDisease ProgressionRNA ViralFemaleViral loadmedicine.medical_specialtyAdolescentGenotypeAlpha interferonSocio-culturaleViremiaAntiviral AgentsRisk AssessmentHEPATITISInternal medicinemedicineHumansViremiaAdolescent; Antiviral Agents; Child; Child Preschool; Disease Progression; Female; Genotype; Hepatitis C Chronic; Humans; Infant; Interferon-alpha; Italy; Liver Cirrhosis; Male; Proportional Hazards Models; Prospective Studies; RNA Viral; Retrospective Studies; Risk Assessment; Time Factors; Treatment Outcome; Viral Load; Viremia; Hepacivirus; GastroenterologyPreschoolProportional Hazards ModelsRetrospective StudiesHepatologybusiness.industryLong-term courseInfantInterferon-alphaHepatitis C Chronicbiology.organism_classificationmedicine.diseaseImmunologyRNAbusinessdescription
Background & Aims: The natural course of chronic hepatitis C (CHC) in children is not well understood. The aim of this study was to assess the long-term course of CHC in a large sample of otherwise healthy children. Methods: From 1990 to 2005, 504 consecutive antihepatitis C virus (HCV)-positive children were enrolled at 12 centers of a national observatory and were followed up retrospectively/prospectively. Results: Putative exposure was perinatal in 283 (56.2%) cases, parenteral in 158 (31.3%), and unknown in 63 (12.5%). At baseline, 477 (94.6%) cases were HCV RNA seropositive, 118 (24.7%) of which were treated with standard interferon α. Ten years after putative exposure, the outcome in 359 HCV RNA-positive, untreated patients was (1) undetectable viremia in 27 (7.5%) (by Cox regression analysis, spontaneous viral clearance was independently predicted by genotype 3 [hazard ratio 6.44; 95% confidence interval: 2.7–15.5]) and (2) persistent viremia in 332 (92%) cases. Six of these 332 cases (1.8%) progressed to decompensated cirrhosis (mean age, 9.6 years). This latter group included 5 Italian children perinatally infected with genotype 1a (4 of the mothers were drug users). Thirty-three (27.9%) treated patients achieved a sustained virologic response. Conclusions: Over the course of a decade, few children with chronic HCV infection cleared viremia spontaneously, and those who did were more likely to have genotype 3. Persistent viral replication led to end-stage liver disease in a small subgroup characterized by perinatal exposure, maternal drug use, and infection with HCV genotype 1a. Children with such features should be considered for early treatment.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-01-01 | Gastroenterology |