Search results for "long-term"
showing 10 items of 436 documents
Long-term course of chronic hepatitis C in children: from viral clearance to end-stage liver disease.
2008
Background & Aims: The natural course of chronic hepatitis C (CHC) in children is not well understood. The aim of this study was to assess the long-term course of CHC in a large sample of otherwise healthy children. Methods: From 1990 to 2005, 504 consecutive antihepatitis C virus (HCV)-positive children were enrolled at 12 centers of a national observatory and were followed up retrospectively/prospectively. Results: Putative exposure was perinatal in 283 (56.2%) cases, parenteral in 158 (31.3%), and unknown in 63 (12.5%). At baseline, 477 (94.6%) cases were HCV RNA seropositive, 118 (24.7%) of which were treated with standard interferon α. Ten years after putative exposure, the outcome in …
The expression mechanism of the residual LTP in the CA1 region of BDNF k.o. mice is insensitive to NO synthase inhibition
2011
Abstract BDNF and nitric oxide signaling both contribute to long-term potentiation (LTP) at glutamatergic synapses, but to date, few studies analyzed the interaction of both signaling cascades in the same synaptic pathway. Here we addressed the question whether the residual LTP in the CA1 region of hippocampal slices from heterozygous BDNF knockout mice (BDNF +/− ) is dependent on nitric oxide (NO) signaling. Extracellular recording of synaptic field potentials elicited by presynaptic Schaffer collateral stimulation was performed in the CA1 region of hippocampal slices of 4- to 6-week-old mice, and LTP was induced by a theta burst stimulation protocol. Application of the nitric oxide inhibi…
Cannabinoid CB1 Receptor Calibrates Excitatory Synaptic Balance in the Mouse Hippocampus
2015
The endocannabinoid system negatively regulates the release of various neurotransmitters in an activity-dependent manner, thereby influencing the excitability of neuronal circuits. In the hippocampus, cannabinoid type 1 (CB1) receptor is present on both GABAergic and glutamatergic axon terminals. CB1 receptor-deficient mice were previously shown to have increased hippocampal long-term potentiation (LTP). In this study, we have investigated the consequences of cell-type-specific deletion of the CB1 receptor on the induction of hippocampal LTP and on CA1 pyramidal cell morphology. Deletion of CB1 receptor in GABAergic neurons in GABA-CB1-KO mice leads to a significantly decreased hippocampal …
The Effect of Long-Term Memory Knowledge on Rehearsal and Refreshing in Working Memory
2011
It was suggested that the impact of long-term knowledge on short-term memory (STM) could either be at encoding and maintenance or at recall (Thorn, Frankish, & Gathercole, 2009). In two experiments, we manipulated the characteristics of long-term knowledge through word-frequency or lexicality. We also varied the implication of the mechanisms of maintenance, refreshing or rehearsal. First, the effect of long-term knowledge on refreshing was investigated manipulating frequency of words to remember and attentional load of the concurrent processing. No interaction between word frequency and cognitive load was found. A second experiment investigated the effect of long-term knowledge on both rehe…
EVALUATION OF THE TECHNICAL EFFICIENCY OF LATVIA’S MUNICIPAL LONG-TERM CARE CENTRES FOR THE ELDERLY
2021
Reforms in Long‐Term Care Policies in Europe: Investigating Institutional Change and Social Impacts edited by CostanzoRanci and EmmanuelePavolini. 20…
2014
Two-year clinical follow up of coronary drug-eluting stent in patients at high risk for coronary restenosis
2008
OBJECTIVE: To evaluate the long-term follow up of patients at high risk for coronary restenosis. BACKGROUND: Drug-eluting stents (DES) have been proven to reduce restenosis and reintervention compared with bare-metal stents (BMS). Although the safety of DES is not different from that of BMS in the short-to-medium term, concern has arisen about the potential for late stent thrombosis related to delayed endothelialization of the stent struts. METHODS: Among 495 patients who underwent percutaneous coronary intervention between June 2004 and March 2005, we retrospectively identified a subset of 150 patients (30%) at high risk for coronary restenosis on the basis of angiographic characteristics …
The impact of process variables on outcomes in a Psychodynamic long term group psychotherapy: A single case study.
2012
Several researches on Group psychotherapy attested the mediating action of some aspects of the group process on the outcome(Martin, Garske & Davis,2000; Tasca, Illing, Ogrodniczuk, Joyce,2009; Burlingame, Mc Clendon & Alonso,2011). This study evaluates the development of the Group process in a semi open, long-term therapeutic group with the aim to identify which specific factors of group therapy (Cohesion, Alliance, and Session Impact) are responsible of the change. The group is composed by 11 patients with DSM I and II Axes diagnosis that have been assessed during 50 session. Outcome Instruments: SCL-90 (Derogatis,1983), OQ-45.2(Lambert, Burlingame,1996;Lo Coco, Prestano, Gullo, Di Stefano…
A Hybrid Agent Model, Mixing Short Term and Long Term Memory Abilities
1999
We present in this paper a novel approach for the modeling of agents able to react and reason under highly dynamic environments. A hybrid agent architecture is described, which allows to integrate the capacity to react rapidly to instantaneous changes in the environment with the capacity to reason more thoroughly about perceptions and actions. These capacities are implemented as independent processes running concurrently, and exploiting different memorizing abilities. Only a short-term memory is made available to reactive agents, whilst long-term memorizing abilities together with the possibility to reason about incomplete information is provided to cognitive agents. This model is currently…
Algorithmic Solution of Arithmetic Problems and Operands-Answer Associations in Long-Term Memory
2001
Many developmental models of arithmetic problem solving assume that any algorithmic solution of a given problem results in an association of the two operands and the answer in memory (Logan & Klapp, 1991; Siegler, 1996). In this experiment, adults had to perform either an operation or a comparison on the same pairs of two-digit numbers and then a recognition task. It is shown that unlike comparisons, the algorithmic solution of operations impairs the recognition of operands in adults. Thus, the postulate of a necessary and automatic storage of operands-answer associations in memory when young children solve additions by algorithmic strategies needs to be qualified.