Search results for "longitudinal"
showing 10 items of 1501 documents
Associations between single-nucleotide polymorphisms of the VEGF gene and long-term prognosis of oral squamous cell carcinoma.
2012
Department of Otorhinolaryngology, Johannes Gutenberg-University, Mainz, GermanyINTRODUCTION: Functional polymorphisms (SNPs) ofthe vascular endothelial growth factor (VEGF) are asso-ciated with the incidence of oral squamous cell carcinoma(OSCC). An impact of VEGF-SNPs on prognosis of OSCCpatients seems possible. Therefore, correlations betweenprognostic parameters of OSCC patients and five VEGF-SNPs were determined.MATERIALS AND METHODS: In a retrospective long-term study, in 113 OSCC patients that underwentcurative resections, five VEGF-SNPs ( 1154 G/A,+405 G/C, +936 C/T, 2578 C/A, and 460 C/T) wereanalyzed. Associations between SNPs and prognosis(incidence of local recurrent disease, seco…
Breakthrough pain in oncology: A longitudinal study
2010
Abstract Context Existing studies on breakthrough pain (BP) have reported different prevalence rates because of different settings, populations, and assessment methods. These studies have used cross-sectional designs, and the relationship of BP with analgesic treatment has not been evaluated. Objectives The aim of this study was to longitudinally assess BP in cancer patients admitted to oncology units. Methods A consecutive sample of patients admitted to oncology centers was selected. At admission (T0), three months after admission (T3), and six months after admission (T6), data on background pain and BP were recorded. BP was assessed in terms of its intensity, duration, number of episodes,…
The potential of serum neurofilament as biomarker for multiple sclerosis
2021
Abstract Multiple sclerosis is a highly heterogeneous disease, and the detection of neuroaxonal damage as well as its quantification is a critical step for patients. Blood-based serum neurofilament light chain (sNfL) is currently under close investigation as an easily accessible biomarker of prognosis and treatment response in patients with multiple sclerosis. There is abundant evidence that sNfL levels reflect ongoing inflammatory-driven neuroaxonal damage (e.g. relapses or MRI disease activity) and that sNfL levels predict disease activity over the next few years. In contrast, the association of sNfL with long-term clinical outcomes or its ability to reflect slow, diffuse neurodegenerativ…
Influence of Social Support Received in Online and Offline Contexts on Satisfaction With Social Support and Satisfaction With Life: A Longitudinal St…
2014
People around the globe now regularly interact with family and friends through social network sites (SNSs). In this article, we investigated the differences between social interactions in online and offline contexts as well as users' satisfaction with the social support received in these contexts. It was hypothesized that SNSs are better set up for the task of leveraging informational support but that they are inferior to offline contexts in terms of emotional or instrumental support. We further assumed that users might feel similarly satisfied with how support is rendered online and offline but that only social support transacted in offline contexts would contribute to overall life satisfa…
Oral health-related quality of life after dental treatment in patients with intellectual disability
2020
Background The influence of dental treatment on oral health-related quality of life (OHRQOL) has rarely been evaluated in patients with intellectual disability (ID) through validated questionnaires. The aim of this study was to estimate the changes on OHRQOL in patients with ID after the implementation of an institutional dental treatment program under general anesthesia using the Franciscan Hospital for Children Oral Health-Related Quality of Life questionnaire (FHCOHRQOL-Q). Material and Methods A prospective longitudinal study was conducted on 85 patients (mean age=24.85 years) classified according to DSM-V whose parents/caregivers completed the FHC-OHRQOL-Q. We analyzed the changes in t…
Exploring the dynamics of protean career orientation, career management behaviors, and subjective career success: An action regulation theory approach
2021
Abstract Due to increased dynamics in the world of work and the resulting responsibility of individuals to shape their careers more independently, there is an increased need to focus on the individual as an active agent in the development of a successful career. Drawing on action regulation theory, this four-wave longitudinal study investigates the dynamic relations between protean career orientation, engagement in career self-management behaviors, and subjective career success over time. Based on a sample of N = 574 German employees, we tested a random intercept cross-lagged panel model (RI-CLPM) to focus on within-person dynamics across four time-points while accounting for stable between…
Work-related goal appraisals and stress during the transition from education to work
2012
Abstract People's personal goals interact with their life situations in many ways. This study examined the appraisals of personal goals during a transition from education to work and their interplay with stress in different domains of life. Finnish young adults (N = 265, 60% female) reported on their goals in the work domain, and related appraisals of importance, attainability, and progress, and the amount of stress they experienced with regard to economic situation, time, and work. The results showed that those individuals who appraised their work goals as important, attainable and progressing well, benefited from their goal striving as evidenced in less stress in all three domains. Moreov…
Parents' role in adolescents' decision on a college major: A weekly diary study
2011
Abstract This study examined 39 adolescents during their transition to university. In standardized weekly diaries over several weeks (M = 8.13) adolescents reported on engagement in career exploration (in-breadth and in-depth self and environmental exploration), their parents' transition-related involvement (frequency of conversations, support, and interference), and their satisfaction with how the transition progressed. The results showed that exploration largely fluctuated across weeks, whereas parent involvement was more stable. Family members' engagement varied according to the phase of the application process the adolescent was involved in. The more adolescents explored during a given …
Social strategies during university studies predict early career work burnout and engagement: 18-year longitudinal study
2011
Abstract This longitudinal study spanning 18 years examined the role of social strategies in early career adaptation. The aim was to find out whether individuals' social strategies measured during their university studies had an impact on work burnout and work engagement measured 10–18 years later. A sample of 292 university students completed the SAQ questionnaire three times while at university and the work burnout inventory three times and the work engagement inventory twice during their early career. According to the results, the higher the initial level of social optimism and the more it increased during university studies, and the lower the initial levels of social withdrawal and soci…
A person-centred approach to investigate the development trajectories of job-related affective well-being: A 10-year follow-up study
2011
The primary aim of this three-wave 10-year follow-up study was to investigate the intra-individual change trajectories of job-related affective well-being among Finnish managers (n = 402). Job-related affective well-being as indicated by anxiety, depression, comfort, and enthusiasm was measured in 1996, 1999, and 2006. The characteristics of the trajectories were sought from experienced career disruptions (i.e., periods of unemployment or lay-offs) and perceived job insecurity. The growth mixture modelling (GMM) revealed altogether three latent trajectories that differed from each other in their mean levels and regard to changes in job-related affective well-being over time: (1) high and im…