6533b7d2fe1ef96bd125ec92

RESEARCH PRODUCT

Associations between single-nucleotide polymorphisms of the VEGF gene and long-term prognosis of oral squamous cell carcinoma.

Eik SchiegnitzJürgen BriegerT. ToyoshimaPeer W. KämmererPeer W. KämmererVinay KumarBilal Al-nawasFelix P. KochManfred Berres

subject

OncologyMaleVascular Endothelial Growth Factor ACancer ResearchAdenosinechemistry.chemical_compoundGene FrequencyPolymorphism (computer science)Longitudinal StudiesAged 80 and overIncidence (epidemiology)SmokingNeoplasms Second PrimaryMiddle AgedPrognosisVascular endothelial growth factorSurvival RateCarcinoma Squamous CellPeriodonticsBiomarker (medicine)FemaleMouth NeoplasmsOral SurgeryAdultmedicine.medical_specialtyGuanineGenotypeSingle-nucleotide polymorphismPolymorphism Single NucleotideDisease-Free SurvivalPathology and Forensic MedicineCytosineYoung AdultInternal medicinemedicineCarcinomaHumansSurvival rateAgedNeoplasm StagingRetrospective Studiesbusiness.industryHaplotypemedicine.diseasestomatognathic diseasesOtorhinolaryngologychemistryHaplotypesNeoplasm Recurrence LocalbusinessThymineFollow-Up Studies

description

Department of Otorhinolaryngology, Johannes Gutenberg-University, Mainz, GermanyINTRODUCTION: Functional polymorphisms (SNPs) ofthe vascular endothelial growth factor (VEGF) are asso-ciated with the incidence of oral squamous cell carcinoma(OSCC). An impact of VEGF-SNPs on prognosis of OSCCpatients seems possible. Therefore, correlations betweenprognostic parameters of OSCC patients and five VEGF-SNPs were determined.MATERIALS AND METHODS: In a retrospective long-term study, in 113 OSCC patients that underwentcurative resections, five VEGF-SNPs ( 1154 G/A,+405 G/C, +936 C/T, 2578 C/A, and 460 C/T) wereanalyzed. Associations between SNPs and prognosis(incidence of local recurrent disease, second cancer,metastases, death, total disease-free survival) wereexamined.RESULTS: After a mean follow-up time of 57.6 months,32 patients had local recurrences; 15 patients had secondcancer, 15 patients metastases, and 23 patients died. Themean disease-free survival was 43.1 months. A significantincreased incidence of OSCC in smokers with the VEGF 2578 A/C and 460 C/T SNP was seen (eachP 2orN > 0) together with the 1154 A/Aallele had a significant worse survival and a worse disease-free survival (both P 2) could be confirmed(P = 0.002).DISCUSSION: Possible reciprocal interactions betweensmoking and VEGF-SNP function were observed. Multi-variate analysis confirmed the VEGF +405 G/G genotypeto be associated with poor survival in advanced OSCCs; afurther use of this haplotype as biomarker has to bediscussed.J Oral Pathol Med (2012)Keywords: advanced; long-term; oral squamous cell carcinoma;prognosis; single-nucleotide polymorphisms; smoking; VEGF

yearjournalcountryeditionlanguage
2012-10-26Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
10.1111/jop.12026https://pubmed.ncbi.nlm.nih.gov/23227881