0000000000181277

AUTHOR

T. Toyoshima

showing 1 related works from this author

Associations between single-nucleotide polymorphisms of the VEGF gene and long-term prognosis of oral squamous cell carcinoma.

2012

Department of Otorhinolaryngology, Johannes Gutenberg-University, Mainz, GermanyINTRODUCTION: Functional polymorphisms (SNPs) ofthe vascular endothelial growth factor (VEGF) are asso-ciated with the incidence of oral squamous cell carcinoma(OSCC). An impact of VEGF-SNPs on prognosis of OSCCpatients seems possible. Therefore, correlations betweenprognostic parameters of OSCC patients and five VEGF-SNPs were determined.MATERIALS AND METHODS: In a retrospective long-term study, in 113 OSCC patients that underwentcurative resections, five VEGF-SNPs ( 1154 G/A,+405 G/C, +936 C/T, 2578 C/A, and 460 C/T) wereanalyzed. Associations between SNPs and prognosis(incidence of local recurrent disease, seco…

OncologyMaleVascular Endothelial Growth Factor ACancer ResearchAdenosinechemistry.chemical_compoundGene FrequencyPolymorphism (computer science)Longitudinal StudiesAged 80 and overIncidence (epidemiology)SmokingNeoplasms Second PrimaryMiddle AgedPrognosisVascular endothelial growth factorSurvival RateCarcinoma Squamous CellPeriodonticsBiomarker (medicine)FemaleMouth NeoplasmsOral SurgeryAdultmedicine.medical_specialtyGuanineGenotypeSingle-nucleotide polymorphismPolymorphism Single NucleotideDisease-Free SurvivalPathology and Forensic MedicineCytosineYoung AdultInternal medicinemedicineCarcinomaHumansSurvival rateAgedNeoplasm StagingRetrospective Studiesbusiness.industryHaplotypemedicine.diseasestomatognathic diseasesOtorhinolaryngologychemistryHaplotypesNeoplasm Recurrence LocalbusinessThymineFollow-Up StudiesJournal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
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