Search results for "lost"
showing 10 items of 626 documents
Interactions of diaryl-polyamines with nucleic acids. Allosteric effects with dinuclear copper complexes
2002
Abstract A series of α,ω-diarylamines with a variable number of ethylenediamine units between terminal naphthylrings shows dramatic affinity changes towards double-stranded nucleic acids, particularly upon complexation with Cu(II) ions. Metal salts alone have under the applied conditions only a negligible effect. The affinity of the metal-free ligands towards nucleic acids shows significant differences to those of the underlying polyamines, with a reversed stabilization of DNA instead of the usually observed preference for RNA. The affinity changes and preliminary NMR studies are in line with intercalation of naphthylrings into the double-stranded nucleic acid, which is hampered by complex …
Superparamagnetic γ-Fe2O3 nanoparticles with tailored functionality for protein separation
2007
Polymer coated superparamagnetic gamma-Fe(2)O(3) nanoparticles were derivatized with a synthetic double-stranded RNA [poly(IC)], a known allosteric activator of the latent (2-5)A synthetase, to separate a single 35 kDa protein from a crude extract which cross reacted with antibodies raised against the sponge enzyme.
Closing in on the toxic domain through analysis of a variant Clostridium difficile cytotoxin B
1995
Strain 1470 is the standard typing strain for serogroup F of Clostridium difficile containing both toxin genes, toxA-1470 and toxB-1470. A polymerase chain reaction (PCR)-based approach to the sequencing of the total toxB-1470 gene identified an open reading frame (ORF) of 7104 nucleotides. In comparison with the previously sequenced toxB of C. difficile VP10463, the toxB-1470 gene has 16 additional nucleotides, 13 within the 5'-untranslated region and three within the coding region. The M(r) of ToxB-1470 is 269,262, with an isoelectric point (IP) of 4.16. The equivalent values for ToxB are M(r) 269,709 and IP 4.13. In comparison with ToxB, ToxB-1470 differs primarily in the N-terminal regi…
Phylogeny and origin of Jurassic irregular echinoids (Echinodermata: Echinoidea).
2006
27 pages; International audience; A phylogenetic analysis of Jurassic irregular echinoids is realized to explore the origin and early evolution of this important subset of echinoids. The phylogeny is based on 39 characters and considers data from apical system architecture, the corona including tuberculation and spines, Aristotle's lantern, and general test shape. Results corroborate the monophyly of Irregularia, and clarify the phylogenetic interrelationships existing between the main groups of irregular echinoids. Specializations of the Aristotle's lantern, spines, tubercles and phyllodes constitute the apomorphies for different taxa, as for the whole of Irregularia. The phylogenetic sign…
Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
2020
Abstract: Background Health system planning requires careful assessment of chronic kidney disease (CKD) epidemiology, but data for morbidity and mortality of this disease are scarce or non-existent in many countries. We estimated the global, regional, and national burden of CKD, as well as the burden of cardiovascular disease and gout attributable to impaired kidney function, for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. We use the term CKD to refer to the morbidity and mortality that can be directly attributed to all stages of CKD, and we use the term impaired kidney function to refer to the additional risk of CKD from cardiovascular disease and gout. Methods Th…
NATION-WIDE SURVEY ON THE USE OF THROMBOPOIETIN RECEPTOR AGONISTS (TPO-RA) FOR THE MANAGEMENT OF IMMUNE THROMBOCYTOPENIA IN CURRENT CLINICAL PRACTICE…
2023
Background: Two thrombopoietin receptor agonists (TPO-RA), romiplostim and eltrombopag, are currently widely adopted as second-line ITP therapy even in absence of robust evidence on their comparative advantages over rituximab or splenectomy or their preferential use in some specific clinical contexts.
 Methods: An on-line survey was distributed between May 2021 and June 2021 to collect standardized information on the use of TPO-RA in Italy.
 Results: Eighty-eight hematologists from 79 centers completed the survey. Eighty-four percent would use TPO-RA earlier than formally indicated, without a preference for young or elderly in 82% of respondents. No clear preference for either rom…
Stigma morphology inAylosterasubg.Mediolobivia(Cactaceae) and its importance for systematic investigation
2013
The stigma of 31 taxa of Aylostera (Cactaceae) was studied using environmental scanning electron microscopy. Seven stigma types could be defined, based on the degree of fusion of the stigmatic lobes and, when these are completely separated (types I and II), their orientation. Four types (types IV, V, VI and VII) are present only in Aylostera subg. Mediolobivia, two of which (types IV and VII) are species-specific. Stigma morphology was found to be a good diagnostic character in Aylostera subg. Mediolobivia, allowing in some cases to distinguish species that had been confused previously. The stigmatic types here defined seem apt to characterize natural groups within the subgenus and are usef…
Rīgas Jezuītu klostera grāmatu saraksts, kuras atrodas Upsalas akadēmijas bibliotēkā
1683
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Resolution of mixtures of steroidal hormones with micellar eluents of sodium dodecyl sulphate and acetonitrile or pentanol
2000
An optimization strategy was applied to explore the capability of hybrid micellar eluents of sodium dodecyl sulphate (SDS), using acetonitrile or pentanol as modifiers, to resolve mixtures of eleven steroids showing a wide range of hydrophobicity (clostebol acetate, dehydrotestosterone, dydrogesterone, medroxyprogesterone, medroxyprogesterone acetate, methandienone, methyltestosterone, progesterone, testosterone, testosterone enanthate and testosterone propionate). The accurate prediction of the retention behaviour of the steroids, with relative errors in the 0.8–1.7% and 0.4–2.9% ranges for SDS-acetonitrile and SDS-pentanol eluents, respectively, demonstrated the reliability of the methodo…
Retention-structure relationship studies for some steroidal hormones in micellar liquid chromatography
2000
The retention behavior in a C18 column of fourteen steroidal hormones (clostebol acetate, dehydrotestosterone, dydrogesterone, medroxyprogesterone, medroxyprogesterone acetate, methandienone, methyltestosterone, nandrolone, nandrolone decanoate, progesterone, testosterone, testosterone enanthate, testosterone propionate and, stanozolol) with pure micellar mobile phases prepared from sodium dodecyl sulfate (SDS), and hybrid mobile phases comprising SDS-acetonitrile and SDS-pentanol, was correlated with their octanol-water partition coefficients. Similar correlations were found with retention data obtained by other authors in gas chromatography, conventional reversed-phase liquid chromatograp…