Search results for "lymphoma."

showing 10 items of 697 documents

Long-lasting remission of primary hepatic lymphoma and hepatitis C virus infection achieved by the alpha-interferon treatment

2004

Primary hepatic lymphoma is a rare but well-defined lymphoma entity that often pursues an aggressive clinical course. Most cases have been described in hepatitis C virus (HCV)-related chronic liver disease patients. Although anthracycline-based chemotherapy has been reported to be highly effective, the best therapeutic strategy has not been defined yet. The prognosis is dismal especially in patients treated with chemotherapy alone or when an advanced liver disease is present. Herein, we describe a case of primary hepatic large B-cell non-Hodgkin’s lymphoma, in a patient with HCV chronic infection. After a minor response with eight cycles of CHOP chemotherapy, a complete and sustained remiss…

Malemedicine.medical_specialtyalpha-interferonHepatitis C virusAlpha interferonCHOPChronic liver diseasemedicine.disease_causeGastroenterologyLiver diseasehemic and lymphatic diseasesInternal medicineremission primary hepatic lymphomaAntineoplastic Combined Chemotherapy Protocolsmedicinevirus infectionHumansUltrasonographyHematologybusiness.industryLymphoma Non-HodgkinLiver NeoplasmsRemission InductionInterferon-alphaHematologyHepatitis CHepatitis C ChronicMiddle Agedmedicine.diseaseLymphomaLong-lastingImmunologyLymphoma Large B-Cell Diffusehepatitis Cbusiness
researchProduct

Cardiovascular dysfunction and vitamin D status in childhood acute lymphoblastic leukemia survivors

2018

Vitamin D (25-OHD) has a role in bone health after treatment for cancer. 25-OHD deficiency has been associated with risk factors for cardiovascular disease, but no data focusing on this topic in childhood cancer survivors have been published. We investigated the 25-OHD status in children treated for acute lymphoblastic leukemia (ALL), and evaluated its influence on vascular function. 25-OHD levels were evaluated in 52 ALL survivors and 40 matched healthy controls. Patients were grouped according to 25-OHD level (< 20 ng/m or ≥ 20 ng/ml). Auxological parameters, biochemical and hemostatic markers of endothelial function (AD, HMW-AD, ET-1, vWFAg, TAT, D-dimers, Fbg, and hs-CRP), ultrasound ma…

Malemedicine.medical_specialtyendocrine system diseasesAdolescentDiseaseAcute lymphoblastic leukemiaurologic and male genital diseasesGastroenterologyC-IMT03 medical and health sciencesYoung Adult0302 clinical medicineRisk Factors030225 pediatricsmedicine.arteryInternal medicinePediatric surgerymedicineVitamin D and neurologyHumans030212 general & internal medicineSurvivorsVitamin DChildChildhood Acute Lymphoblastic LeukemiaUnivariate analysisbusiness.industryAbdominal aortaConfoundingnutritional and metabolic diseasesCancerPrecursor Cell Lymphoblastic Leukemia-Lymphomamedicine.diseaseVitamin D DeficiencyCardiovascular diseaseChild PreschoolPediatrics Perinatology and Child HealthFemaleEndothelium VascularbusinessBiomarkersVascular ultrasound studie
researchProduct

Cancer prevalence is increased in females with sleep apnoea: data from the ESADA study

2019

[No abstract available]

MaleobesityLetterDatabases FactualDownload[SDV]Life Sciences [q-bio]cigarette smokingPolysomnographycancer riskdisease burdenapnea hypopnea indexsleep disordered breathingstudy design0302 clinical medicinepolysomnographyRisk FactorsNothingcancer diagnosisNeoplasmsmiddle agedgenderPrevalence030212 general & internal medicineSleep studyobstructive sleep apneaSleep Apnea Obstructiveeducation.field_of_studyanthropometryquantitative analysismedicine.diagnostic_testadultrisk assessmentclinical trialcohort analysisprostate cancerpulse oximetry[SDV] Life Sciences [q-bio]Europenot availablecomorbidityagedfemalewaist hip ratiocolon cancerpriority journalrisk factorfactual databasedisease severitycerebrovascular accidentPulmonary and Respiratory Medicinemedicine.medical_specialtyalcohol consumptionintermittent hypoxiaPopulationMEDLINElymphomaSettore MED/10 - Malattie Dell'Apparato Respiratoriomalignant neoplasmcancer growth03 medical and health sciencesmelanomamedicinecancercross-sectional studyHumanscontrolled studyhumaneducationCancer prevalencehypoxiabusiness.industrystatistical modelConflict of interestpredictionmajor clinical studybody massoxygen saturationlung cancermulticenter studyCross-Sectional StudiesLogistic Modelsage030228 respiratory systemdisease severity assessmentFamily medicineoxygen desaturation indexhead and neck cancerHuman medicinebusinessneoplasmEuropean Respiratory Journal
researchProduct

Chromatic-achromatic perimetry in four clinic cases: Glaucoma and diabetes

2015

Color perimetry has interesting clinical application for the diagnosis and detection of certain eye conditions, due to the variations that certain diseases can cause in chromatic thresholds, both in the red-green (RG) and the blue-yellow (BY) pathways.[1,2,3,4] The separate study of the visual function of both the chromatic and achromatic mechanisms could be more efficient in detecting sensitivity variations, and such variations would not be obscured by the intrusion of other mechanisms. Currently, the supply of conventional perimeters that are capable of performing a chromatic perimetry test is very limited and with reduced options regarding the possibility of choosing the physical charact…

Maleretinakoniohemangioblastomagenetic structuresComputer sciencemelanocytosisGlaucomaretinal vasoproliferative tumorEyeTwo stageslaw.inventionintra-arterial chemotherapyretinal capillary hemangiomaIntrusionlcsh:Ophthalmologylawperiocular chemotherapyintravitreal chemotherapytreatmentdiabetesenhanced depth imagingDiabetesenhanced depth imaging optical coherence tomographyMiddle AgedhemangiomaAchromatic lensFemaleOriginal Articleuveal melanomanevusAdulttumorchoroidal hemangiomaCiliary bodymonosomy 3lymphomaStimulus (physiology)Color spaceAutoflouroscenceuvearetinoblastomaContrast SensitivityosteomaCavernous hemangiomaParvoMagnoResearch basedmedicinemelanomagene expression profilingHumansmetastasisChemotherapyChromatic scalemetastasesirisÓpticachromatic perimetryoptical coherence tomographyintravenous chemotherapybusiness.industryChoroidKonioSubtenon′s chemotherapyReproducibility of ResultsPattern recognitionGlaucomamedicine.diseaseAchromatic perimetrymagnoOphthalmologyglaucomaDiabetes Mellitus Type 2lcsh:RE1-994parvoOptometryVisual Field TestsAstrocytic hamartomavitreous seedsArtificial intelligenceprognosisVisual FieldsbusinessChromatic perimetrymalignancy
researchProduct

Splenic marginal zone lymphoma: A prognostic model for clinical use

2006

The Integruppo Italiano Linfomi (IIL) carried out a study to assess the outcomes of splenic marginal zone lymphoma and to identify prognostic factors in 309 patients. The 5-year cause-specific survival (CSS) rate was 76%. In univariate analysis, the parameters predictive of shorter CSS were hemoglobin levels below 12 g/dL (P < .001), albumin levels below 3.5 g/dL (P = .001), International Prognostic Index (IPI) scores of 2 to 3 (P < .001), lactate dehydrogenase (LDH) levels above normal (P < .001), age older than 60 years (P = .01), platelet counts below 100 000/μL (P = .04), HbsAg-positivity (P = .01), and no splenectomy at diagnosis (P = .006). Values that maintained a negative influence …

Malesplenic marginal zone lymphoma; prognostic factors; International Prognostic Index (IPI)VILLOUS LYMPHOCYTESHydro-LyaseB-CELLLongitudinal StudiePredictive Value of TestInternational Prognostic Index (IPI)BiochemistryGastroenterologyHemoglobinschemistry.chemical_compoundInternational Prognostic IndexRisk FactorsBONE-MARROW INFILTRATION; NON-HODGKINS-LYMPHOMA; C VIRUS-INFECTION; VILLOUS LYMPHOCYTES; B-CELLBONE-MARROW INFILTRATIONAge FactorLongitudinal StudiesMultivariate AnalysiAged 80 and overUnivariate analysisHematologyMortality rateAge FactorsHematologyMiddle AgedPrognosisSplenic NeoplasmSurvival RatePredictive value of testsHumanAdultmedicine.medical_specialtyLymphoma B-CellPrognosiImmunologysplenic marginal zone lymphomaDisease-Free SurvivalPredictive Value of TestsAlbuminsInternal medicineLactate dehydrogenaseAdult; Age Factors; Aged; Aged 80 and over; Albumins; Disease-Free Survival; Hemoglobins; Humans; Hydro-Lyases; Longitudinal Studies; Lymphoma B-Cell; Male; Middle Aged; Multivariate Analysis; Platelet Count; Predictive Value of Tests; Prognosis; Risk Factors; Splenic Neoplasms; Survival Rate; Models Theoretical; HematologymedicineHumansHemoglobinNON-HODGKINS-LYMPHOMASplenic marginal zone lymphomaSurvival rateHydro-LyasesAgedPlatelet Countbusiness.industrySplenic NeoplasmsAlbuminRisk Factorprognostic factorsCell BiologyModels Theoreticalmedicine.diseaseSurgerychemistryMultivariate AnalysisbusinessC VIRUS-INFECTION
researchProduct

Report of a case of localized Castleman's disease with progression to malignant lymphoma.

1993

Malignant lymphomaPathologymedicine.medical_specialtyLymphomabusiness.industryCastleman DiseasemedicineHumansGeneral MedicineDiseasebusinessAmerican journal of clinical pathology
researchProduct

Sjogren syndrome and parotid marginal zone lymphoma: Report of a case and review of literature

2020

Five percent of the cancers in the parotid region are non-hodgkin lymphomas. This lymphoma, involving the mucosa-associated lymphoid tissue (MALT), is called MALToma. A chronic autoimmune inflammatory process of the parotid gland, such as Sjogren's syndrome, results in an increased incidence of parotid MALToma. Biopsy of the parotid is essential for appropriate diagnosis; this can then be completed by radiotherapy, chemotherapy or therapy with monoclonal antibodies according to the stage of the disease. This study shows a clinical case of a 50-year-old patient with Sjogren's syndrome who developed a parotid MALToma.

Marginal zone lymphomaParotid lymphomaSjogren syndromeMALToma
researchProduct

Screening of fractions from marine sponges and other invertebrates to identify new lead compounds with anti-tumor activity in lymphoma models

2020

Diffuse large B-cell lymphoma (DLBCL) is the commonest type of lymphomas, accounting for 30%-40% of new cases each year. Despite the big improvements achieved in the treatment, still 25–40% of patients still succumb due to refractory or relapsed disease. This highlights the need of new drugs for this cancer. The marine environment has recently been recognized as a source of anti-cancer compounds, as demonstrated by different marine drugs approved by different regulatory agencies (trabectedin, cytarabine, eribulin, plitidepsin) or as components of antibody drug conjugates for lymphoma patients (monomethyl auristatin E in polatuzumab vedotin and brentuximab vedotin). Here, we present a large …

Marine spongesAntitumor activityCancer ResearchlymphomaBiologymedicine.diseaseLymphomaLead (geology)OncologymedicineCancer researchanti-tumor activityInvertebratemarine sponge
researchProduct

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

2015

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10−15) and HLA-B (rs2922994, P=2.43 × 10−9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

Medicin och hälsovetenskapLymphomaResearch Support U.S. Gov't P.H.S.Follicular lymphomaGeneral Physics and AstronomyGenome-wide association studyMarginal ZoneP.H.S.Medical and Health SciencesMajor Histocompatibility ComplexPolymorphism (computer science)Non-U.S. Gov'tGENE-EXPRESSIONCELL DEVELOPMENTGeneticsMultidisciplinaryMembrane GlycoproteinsResearch Support Non-U.S. Gov'tSingle NucleotideMarginal zone3. Good healthMultidisciplinary SciencesScience & Technology - Other TopicsNON-HODGKIN-LYMPHOMASUSCEPTIBILITY LOCIGenotypeCèl·lules BEuropean Continental Ancestry GroupEPIDEMIOLOGIC RESEARCHHuman leukocyte antigenBiologyResearch SupportPolymorphism Single NucleotideCLASSIFICATIONGeneral Biochemistry Genetics and Molecular BiologyWhite PeopleArticleN.I.H.Research Support N.I.H. ExtramuralMarginal zone lymphomaMD MultidisciplinaryGenetic variationmedicineJournal ArticleHumansPolymorphismGASTRIC LYMPHOMAIntramuralB cellsScience & TechnologyButyrophilinsGastric lymphomaB-CellExtramuralComputational BiologyGeneral ChemistryLymphoma B-Cell Marginal ZoneResearch Support N.I.H. Intramuralmedicine.diseaseRISK LOCIRHEUMATOID-ARTHRITISLymphomaMalaltia de HodgkinImmunologyU.S. Gov'tHodgkin's diseaseFOLLICULAR LYMPHOMAGenome-Wide Association Study
researchProduct

Whole-Body Magnetic Resonance Imaging: Current Role in Patients with Lymphoma.

2021

Imaging of lymphoma is based on the use of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) and/or contrast-enhanced CT, but concerns have been raised regarding radiation exposure related to imaging scans in patients with cancer, and its association with increased risk of secondary tumors in patients with lymphoma has been established. To date, lymphoproliferative disorders are among the most common indications to perform whole-body magnetic resonance imaging (MRI). Whole-body MRI is superior to contrast-enhanced CT for staging the disease, also being less dependent on histology if compared to 18F-FDG-PET/CT. As well, it does not require exposure to i…

Medicine (General)medicine.medical_specialtydiffusion-weighted imagingClinical BiochemistryWhole body imagingLymphoproliferative disorderslymphomaReviewwhole-body imaging030218 nuclear medicine & medical imagingIonizing radiation03 medical and health sciencesR5-9200302 clinical medicinehemic and lymphatic diseasesmedicinemagnetic resonance imagingmedicine.diagnostic_testbusiness.industryCancerMagnetic resonance imagingstagingmedicine.diseaseLymphomaPositron emission tomography030220 oncology & carcinogenesisRadiologybusinessDiffusion MRIDiagnostics (Basel, Switzerland)
researchProduct