Search results for "mIRs"
showing 10 items of 65 documents
Demosponge EST sequencing reveals a complex genetic toolkit of the simplest metazoans.
2010
Sponges (Porifera) are among the simplest living and the earliest branching metazoans. They hold a pivotal role for studying genome evolution of the entire metazoan branch, both as an outgroup to Eumetazoa and as the closest branching phylum to the common ancestor of all multicellular animals (Urmetazoa). In order to assess the transcription inventory of sponges, we sequenced expressed sequence tag libraries of two demosponge species, Suberites domuncula and Lubomirskia baicalensis, and systematically analyzed the assembled sponge transcripts against their homologs from complete proteomes of six well-characterized metazoans--Nematostella vectensis, Caenorhabditis elegans, Drosophila melanog…
Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
2017
Natural products or nutraceuticals have been shown to elicit anti-aging, anti-cancer and other health-enhancing effects. A key target of the effects of natural products may be the regulation of microRNA (miR) expression which results in cell death or prevents aging, diabetes, cardiovascular and other diseases. This review will focus on a few natural products, especially on resveratrol (RES), curcumin (CUR) and berberine (BBR). RES is obtained from the skins of grapes and other fruits and berries. RES may extend human lifespan by activating the sirtuins and SIRT1 molecules. CUR is isolated from the root of turmeric (Curcuma longa). CUR is currently used in the tutreatment of many disorders, …
Critical Roles of EGFR family members in breast cancer and breast cancer stem cells: Targets for therapy
2016
The roles of the epidermal growth factor receptor (EGFR) signaling pathway in various cancers including breast, bladder, brain, colorectal, esophageal, gastric, head and neck, hepatocellular, lung, neuroblastoma, ovarian, pancreatic, prostate, renal and other cancers have been keenly investigated since the 1980's. While the receptors and many downstream signaling molecules have been identified and characterized, there is still much to learn about this pathway and how its deregulation can lead to cancer and how it may be differentially regulated in various cell types. Multiple inhibitors to EGFR family members have been developed and many are in clinical use. Current research often focuses o…
MiR-205-5p inhibition by locked nucleic acids impairs metastatic potential of breast cancer cells.
2018
AbstractMir-205 plays an important role in epithelial biogenesis and in mammary gland development but its role in cancer still remains controversial depending on the specific cellular context and target genes. We have previously reported that miR-205-5p is upregulated in breast cancer stem cells targeting ERBB pathway and leading to targeted therapy resistance. Here we show that miR-205-5p regulates tumorigenic properties of breast cancer cells, as well as epithelial to mesenchymal transition. Silencing this miRNA in breast cancer results in reduced tumor growth and metastatic spreading in mouse models. Moreover, we show that miR-205-5p knock-down can be obtained with the use of specific lo…
Roles of TP53 in determining therapeutic sensitivity, growth, cellular senescence, invasion and metastasis.
2016
TP53 is a critical tumor suppressor gene that regulates cell cycle progression, apoptosis, cellular senescence and many other properties critical for control of normal cellular growth and death. Due to the pleiotropic effects that TP53 has on gene expression and cellular physiology, mutations at this tumor suppressor gene result in diverse physiological effects. T53 mutations are frequently detected in numerous cancers. The expression of TP53 can be induced by various agents used to treat cancer patients such as chemotherapeutic drugs and ionizing radiation. Radiation will induce Ataxia telangiectasia mutated (ATM) and other kinases that results in the phosphorylation and activation of TP53…
miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity.
2016
Aberrant immune activation mediated by T effector cell populations is pivotal in the onset of autoimmunity in type 1 diabetes (T1D). T follicular helper (TFH) cells are essential in the induction of high-affinity antibodies, and their precursor memory compartment circulates in the blood. The role of TFH precursors in the onset of islet autoimmunity and signaling pathways regulating their differentiation is incompletely understood. Here, we provide direct evidence that during onset of islet autoimmunity, the insulin-specific target T-cell population is enriched with a C-X-C chemokine receptor type 5 (CXCR5)(+)CD4(+) TFH precursor phenotype. During onset of islet autoimmunity, the frequency o…
Dzimis, lai mirtu: nāves cēloņi Vidzemē 19.gadsimtā
2015
Darba pētījums veltīts Latvijas vēsturē maz pētītai tēmai par nāves cēloņiem 19. gs., analizējot un salīdzinot baznīcu metrikās minētos nāves cēloņus trīs Vidzemes luterāņu draudzēs – Ērģemes, Liepupes un Valmieras laika posmā no 1834. līdz 1900. g. Darba mērķis ir sniegt ieskatu mirstības un nāves cēloņu raksturojumā Vidzemē 19. gs. Darba sākumā apskatīta vispārīgā situācija Vidzemē 19. gs. un medicīnas attīstība Eiropā un Latvijas teritorijā 19. gs. Vairākās nodaļās izvērsti sastopamākie nāves cēloņi, kas iedalīti vairākās grupās – bērnu un zīdaiņu nāves cēloņi, epidēmijas, pieaugušo nāves cēloņi un citi cēloņi. Pētījuma rezultāti apliecina, ka 19. gs. joprojām bija augsta zīdaiņu un bērn…
Nemirstība kā ideāls Ge Hun daiļradē
2019
Maģistra darba tēma „Nemirstība kā ideāls Ge Hun darbos” veltīta domātāja un alķīmijas meistara Ge Hun (283.-343.) darbu izpētei un analīzei. Ge Hun, ko Rietumu sinologi raksturo kā izcilāko daoisma alķīmiķi, rakstnieku un mediķi, rakstiskā veidā fiksēja daoisma metodes nemirstības sasniegšanai un jaunības saglabāšanai, pēc kā tiecās ne tikai daoisma sekotāji, bet arī vienkāršie cilvēki. Viņš ir pazīstams gan kā vērtīgu alķīmijas tekstu autors, gan ir devis arī nenovērtējami lielu ieguldījumu ķīniešu tradicionālās medicīnas pētījumiem arī mūsdienās. Viņa teksti bija nozīmīgi akupunktūras un piededzināšanas teoriju bagātināšanā un veicināja šo tehniku attīstību. Šī darba mērķis ir izpētīt al…
Der Philosoph W. Solowioff und das Judentum [Philosoph W. Solowjow und das Judentum]
1927
Inhaltsverzeichnis: Vorwort 5 l. W. Solowioffs und das Judentum ll. W. Solowioffs Protest gegen den Antisemitismus 17 111. Das religiöse Gewissen erweckt in W. S. lnteresse für das Judentum 22 IV. W. Solowioffs Interesse für Juden 29 V. Die Bekanntschaft mit Juden macht W. S. zu ihrem Apologeten 32 VI. Juden zuverteidigen war für W. S. religiöse und patriotische Pflicht 35 Vll. W. Solowioffs jüdische Apologie 39 Vlll. W. S. über das Verhältnis des Christentums zum Judentum 46 IX. W. S. über die Beziehungen der Evangelien zum Talmud 57 X. W. Solowioffs originelle Polemik. 65 Xl. Widerlegung der nationalen Beschuldigungen 74 Xll. Widerlegung der ökonomischen Beschuldigung 77 Xlll. Wideflegung…
Desert dust aerosol air mass mapping in the western Sahara, using particle properties derived from space-based multi-angle imaging
2009
Coincident observations made over the Moroccan desert during the Sahara mineral dust experiment (SAMUM) 2006 field campaign are used both to validate aerosol amount and type retrieved from multi-angle imaging spectroradiometer (MISR) observations, and to place the suborbital aerosol measurements into the satellite's larger regional context. On three moderately dusty days during which coincident observations were made, MISR mid-visible aerosol optical thickness (AOT) agrees with field measurements point-by-point to within 0.05–0.1. This is about as well as can be expected given spatial sampling differences; the space-based observations capture AOT trends and variability over an extended regi…