Search results for "machine"
showing 10 items of 2592 documents
A Machine Learning-Based Prediction Platform for P-Glycoprotein Modulators and Its Validation by Molecular Docking
2019
P-glycoprotein (P-gp) is an important determinant of multidrug resistance (MDR) because its overexpression is associated with increased efflux of various established chemotherapy drugs in many clinically resistant and refractory tumors. This leads to insufficient therapeutic targeting of tumor populations, representing a major drawback of cancer chemotherapy. Therefore, P-gp is a target for pharmacological inhibitors to overcome MDR. In the present study, we utilized machine learning strategies to establish a model for P-gp modulators to predict whether a given compound would behave as substrate or inhibitor of P-gp. Random forest feature selection algorithm-based leave-one-out random sampl…
Kernel-Based Framework for Multitemporal and Multisource Remote Sensing Data Classification and Change Detection
2008
The multitemporal classification of remote sensing images is a challenging problem, in which the efficient combination of different sources of information (e.g., temporal, contextual, or multisensor) can improve the results. In this paper, we present a general framework based on kernel methods for the integration of heterogeneous sources of information. Using the theoretical principles in this framework, three main contributions are presented. First, a novel family of kernel-based methods for multitemporal classification of remote sensing images is presented. The second contribution is the development of nonlinear kernel classifiers for the well-known difference and ratioing change detectio…
Modelling and Control of a 2-DOF Robot Arm with Elastic Joints for Safe Human-Robot Interaction
2021
Collaborative robots (or cobots) are robots that can safely work together or interact with humans in a common space. They gradually become noticeable nowadays. Compliant actuators are very relevant for the design of cobots. This type of actuation scheme mitigates the damage caused by unexpected collision. Therefore, elastic joints are considered to outperform rigid joints when operating in a dynamic environment. However, most of the available elastic robots are relatively costly or difficult to construct. To give researchers a solution that is inexpensive, easily customisable, and fast to fabricate, a newly-designed low-cost, and open-source design of an elastic joint is presented in this w…
ADME Prediction with KNIME: Development and Validation of a Publicly Available Workflow for the Prediction of Human Oral Bioavailability.
2020
In silico prediction of human oral bioavailability is a relevant tool for the selection of potential drug candidates and for the rejection of those molecules with less probability of success during the early stages of drug discovery and development. However, the high variability and complexity of oral bioavailability and the limited experimental data in the public domain have mainly restricted the development of reliable in silico models to predict this property from the chemical structure. In this study we present a KNIME automated workflow to predict human oral bioavailability of new drug and drug-like molecules based on five machine learning approaches combined into an ensemble model. Th…
Advanced computation in cardiovascular physiology: New challenges and opportunities
2021
Recent developments in computational physiology have successfully exploited advanced signal processing and artificial intelligence tools for predicting or uncovering characteristic features of physiological and pathological states in humans. While these advanced tools have demonstrated excellent diagnostic capabilities, the high complexity of these computational 'black boxes’ may severely limit scientific inference, especially in terms of biological insight about both physiology and pathological aberrations. This theme issue highlights current challenges and opportunities of advanced computational tools for processing dynamical data reflecting autonomic nervous system dynamics, with a speci…
Multi-agent Reinforcement Learning for Simulating Pedestrian Navigation
2012
In this paper we introduce a Multi-agent system that uses Reinforcement Learning (RL) techniques to learn local navigational behaviors to simulate virtual pedestrian groups. The aim of the paper is to study empirically the validity of RL to learn agent-based navigation controllers and their transfer capabilities when they are used in simulation environments with a higher number of agents than in the learned scenario. Two RL algorithms which use Vector Quantization (VQ) as the generalization method for the space state are presented. Both strategies are focused on obtaining a good vector quantizier that generalizes adequately the state space of the agents. We empirically state the convergence…
Computational issues in fitting joint frailty models for recurrent events with an associated terminal event.
2020
Abstract Background and objective: Joint frailty regression models are intended for the analysis of recurrent event times in the presence of informative drop-outs. They have been proposed for clinical trials to estimate the effect of some treatment on the rate of recurrent heart failure hospitalisations in the presence of drop-outs due to cardiovascular death. Whereas a R-software-package for fitting joint frailty models is available, some technical issues have to be solved in order to use SASⓇ 1 software, which is required in the regulatory environment of clinical trials. Methods: First, we demonstrate how to solve these issues by deriving proper likelihood-decompositions, in particular fo…
A framework for modelling the biomechanical behaviour of the human liver during breathing in real time using machine learning
2017
Progress in biomechanical modelling of human soft tissue is the basis for the development of new clinical applications capable of improving the diagnosis and treatment of some diseases (e.g. cancer), as well as the surgical planning and guidance of some interventions. The finite element method (FEM) is one of the most popular techniques used to predict the deformation of the human soft tissue due to its high accuracy. However, FEM has an associated high computational cost, which makes it difficult its integration in real-time computer-aided surgery systems. An alternative for simulating the mechanical behaviour of human organs in real time comes from the use of machine learning (ML) techniq…
Comparing Tangible and Fully Virtual Haptic Systems for HMI Studies in Simulated Driving Situations
2019
International audience; The contribution of tangible and intangible feedback is compared for virtual tactile car Human-Machine Interfaces (HMI) design, to measure their performance both in static conditions and while driving. A subjectively calibrated transparent glass provides tangible passive haptics, and visual cues are used to study sensory substitution-based intangible interactions. The results show that the performance of the subjects was significantly improved in driving conditions as they interacted faster, more accurately and with a higher satisfaction. In addition, our findings highlight that the contribution of tangible systems is significantly lower in driving conditions, raisin…
Bag-of-word based brand recognition using Markov Clustering Algorithm for codebook generation
2015
International audience; In order to address the issue of counterfeiting online, it is necessary to use automatic tools that analyze the large amount of information available over the Internet. Analysis methods that extract information about the content of the images are very promising for this purpose. In this paper, a method that automatically extract the brand of objects in images is proposed. The method does not explicitly search for text or logos. This information is implicitly included in the Bag-of-Words representation. In the Bag-of-Words paradigm, visual features are clustered to create the visual words. Despite its shortcomings, k-means is the most widely used algorithm. With k-mea…