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The parasitoid species complex associated with sexual and parthenogenetic Naryciinae (Lepidoptera: Psychidae): Integrating ecological and molecular a…

2011

This study describes the parasitoid species complex associated with seven closely related species of sexual (Siederia rupicollella, S. listerella, Dahlica lazuri, D. charlottae and D. lichenella) and parthenogenetic (Dahlica fennicella and D. triquetrella) Naryciinae (Lepidoptera: Psychidae) in Central Finland. A thorough ecological analysis of all the species of parasitoids recorded was combined with analyses of molecular data. Mitochondrial and nuclear DNA data were obtained from all the species in order to (1) detect cryptic species associated with host specialization, (2) assign undescribed males to females, and (3) verify the morphological identification of closely related species. A D…

All polarization-maintaining assively mode-locked yb-doped fiber laser : pulse compression using an anomalous polarization-maintaining photonic cryst…

2019

We report the generation of short pulses at 1 μm using an all-polarization-maintaining (PM) fiber configuration. The pulses are provided by an all normal-dispersion Fabry-Perot Yb-doped cavity and are compressed with an anomalous polarization-maintaining photonic crystal fiber (PM PCF). Opposed to standard configurations; here the filtering action is solely performed by the finite bandwidth of the gain medium. The laser generates 8 ps width sech 2 profile pulses at 1046.8 nm with a −10 dB bandwidth of 5.9 nm. After compression using the PM PCF, pulses with an FWHM of 3 ps were obtained, limited by the actual value of the available anomalous dispersion. We also report the changes in the outp…

Romain D. Huret, American Tax Resisters

2014

À l’occasion d’un dîner privé organisé pour financer sa campagne présidentielle de 2012, le candidat du Parti républicain, Mitt Romney, prononça un discours, enregistré à son insu, au cours duquel il expliquait candidement à son auditoire que « 47 % des gens voteront pour le président [Obama] quoi qu’il arrive. Ces 47 % qui le soutiennent sont des assistés. Ils se voient comme des victimes, ils pensent que le gouvernement est responsable de leur bien-être […] Ce sont des gens qui ne sont pas ...

Yoga en España. Proceso de regulación profesional

2015

New approaches to spirituality go hand in hand with emerging physical, psychological and spiritual movements that have had a clear impact on many areas, and in particular on health and well-being. It is increasingly common to find nurses teaching yoga or doctors prescribing mindfulness. Use of socalled Complementary and Alternative Medicine (CAM) is becoming mainstream. Health centres, medical practices and even schools are offering a growing number of alternative therapies, resulting in the need for effective legal regulation of these activities, both in terms of professional recognition and training. In Spain, recent legislation represents a significant breakthrough in the regulation of y…

The Hyperreal Gambler : On the Visual Construction of Men in Online Poker Ads

2017

Online poker, like gambling in general, is predominantly a male activity. Thus, poker ads most often depict men as their protagonists. According to Jean Baudrillard, advertising can be seen as a ‘plebiscite whereby mass consumer society wages a perpetual campaign of self- endorsement.’ Ads often use stereotypical imagery for establishing a shared experience of identification with the consumer, and since their role is to sell rather than to portray the realities of life, they often have an exaggerated and monolithic – or, hyperreal – way of representing gender. This article offers an analysis of the ways in which men are portrayed in the ads of Poker Magazine Finland in the volume of 2009 (a…

Expériences croisées face à l’épreuve de la maladie d’Alzheimer. Quand personnes malades et proches dessinent des trajectoires d’accompagnement contr…

2018

Cadre de recherche : La littérature consacrée aux familles des personnes malades d’Alzheimer met en lumière la charge que peut représenter l’accompagnement d’une personne malade, mais aussi la diversité des expériences vécues par les proches. Malgré l’abondance de littérature, deux limites sont constatées : ces travaux se fondent strictement sur le discours des proches et ils appréhendent l’expérience de l’accompagnement sur la base d’une approche synchronique.Objectifs : Cet article a l’ambition de dépasser ces deux limites en mettant en dialogue, dans la durée, les témoignages des personnes malades d’Alzheimer et de leurs proches. Nous proposons d’analyser ce qui se joue dans les dynamiqu…

2018

Tetraspanins (Tspans) are a family of four-span transmembrane proteins, known as plasma membrane “master organizers.” They form Tspan-enriched microdomains (TEMs or TERMs) through lateral association with one another and other membrane proteins. If multiple microdomains associate with each other, larger platforms can form. For infection, viruses interact with multiple cell surface components, including receptors, activating proteases, and signaling molecules. It appears that Tspans, such as CD151, CD82, CD81, CD63, CD9, Tspan9, and Tspan7, coordinate these associations by concentrating the interacting partners into Tspan platforms. In addition to mediating viral attachment and entry, these …

Genome-Wide Inhibition of Pro-atherogenic Gene Expression by Multi-STAT Targeting Compounds as a Novel Treatment Strategy of CVDs.

2018

Cardiovascular diseases (CVDs), including atherosclerosis, are globally the leading cause of death. Key factors contributing to onset and progression of atherosclerosis include the pro-inflammatory cytokines Interferon (IFN)a and IFN? and the Pattern Recognition Receptor (PRR) Toll-like receptor 4 (TLR4). Together, they trigger activation of Signal Transducer and Activator of Transcription (STAT)s. Searches for compounds targeting the pTyr-SH2 interaction area of STAT3, yielded many small molecules, including STATTIC and STX-0119. However, many of these inhibitors do not seem STAT3-specific. We hypothesized that multi-STAT-inhibitors that simultaneously block STAT1, STAT2, and STAT3 activit…

RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis—Novel Targets for Therapy?

2019

Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2, and LNPEPS), which are involved in antigen processing and presentation to T-cells, and several genes (IL23R, IL6R, STAT3, JAK2, IL1R1/2, IL12B, and IL7R) involved in IL23 driven pathways of inflammation. AS is also strongly associated with polymorphisms in two transcription factors, RUNX3 and T-bet (encoded by TBX21), which are important in T-cell development and function. The influence of these genes on the pathogenesis of AS and their potential for identifying drug targets is discussed here.

Prediction of Specific TCR-Peptide Binding From Large Dictionaries of TCR-Peptide Pairs

2019

Abstract The T cell repertoire is composed of T cell receptors (TCR) selected by their cognate MHC-peptides and naive TCR that do not bind known peptides. While the task of distinguishing a peptide-binding TCR from a naive TCR unlikely to bind any peptide can be performed using sequence motifs, distinguishing between TCRs binding different peptides requires more advanced methods. Such a prediction is the key for using TCR repertoires as disease-specific biomarkers. We here used large scale TCR-peptide dictionaries with state-of-the-art natural language processing (NLP) methods to produce ERGO (pEptide tcR matchinG predictiOn), a highly specific classifier to predict which TCR binds to which…