Search results for "maintenance"
showing 10 items of 392 documents
Induction Therapy with Idarubicin, Ara-C, and VP-16, Followed by G-CSF and Maintenance Immunotherapy with Interleukin-2 for High-Risk AML
1996
Aggressive chemotherapy followed by administration of G-CSF and maintenance therapy with interleukin-2 was evaluated in 16 patients with advanced myelodxysplastic syndrome, 47 patients with AML evolving from myelodysplastic syndromes, 3 patients with subacute myeloid leukemia and 5 patients with secondary AML. Median age was 59 years (range: 23 to 76 years). All patients achieving a complete remission (CR) after two induction courses went on to receive two consolidation courses, to be followed by randomization to either high-dose or low-dose IL-2 to evaluate the potential of IL-2 to eliminate residual leukemic cells and to prolong the duration of CR. Patients ≤ age 55 with an HLA identical …
A review of the Digital Twin technology for fault detection in buildings
2022
This study aims to evaluate the utilization of technology known as Digital Twin for fault detection in buildings. The strategy consisted of studying existing applications, difficulties, and possibilities that come with it. The Digital Twin technology is one of the most intriguing newly discovered technologies rapidly evolving; however, some problems still need to be addressed. First, using Digital Twins to detect building faults to prevent future failures and cutting overall costs by improving building maintenance is still ambiguous. Second, how Digital Twin technology may be applied to discover inefficiencies inside the building to optimize energy usage is not well defined. To address thes…
Combined fuzzy TOPSIS and AHP-based methodology for the prioritization of maintenance key performance indicators: Application to an oil refinery plant
2017
A Maintenance Performance Measurement model based on the use of Maintenance Key Performance Indicators (MKPIs) is proposed in the present paper. Referring to a specific industrial context, a multi-level hierarchical structure is firstly designed to highlight the most meaningful perspectives which affect the maintenance performance. Then, MKPIs selected from the literature or properly formulated to detail some particular perspective of the investigated maintenance process are assigned to the hierarchical framework and prioritized by a Fuzzy Technique for Order of Preference by Similarity to Ideal Solution (FTOPSIS) and Analytic Hierarchy Process (AHP)-based approach.
Numerical investigation of rain droplet impact on offshore wind turbine blades under different rainfall conditions: A parametric study
2020
The leading edge of a fiber composite wind turbine blade (WTB) is prone to erosion damages due to repeated rain droplet impact during its service life. Such damages are critical to the blade's aerodynamic as well as structural performance, ultimately resulting in substantial repair costs. An effective design of a coating material for WTB is necessary and its analysis must include variables associated with erosive rain droplets such as (1) droplet diameter, (2) impact velocity, and (3) droplet impact angle. The present paper develops and validates a coupled fluid structure interaction (FSI) computational model for simulating rain droplet impact on WTBs, where the structure domain is modelled…
Corporate Social Irresponsibility and Legitimacy Maintenance: Lessons from the Parmalat Scandal
2014
Audience decisions regarding whether to continue to support a corporation after it has been perceived as culpable for socially irresponsible behaviour is “coin of the realm” in selecting which firms (or which parts of a firm) will be able to survive a CSI-scandal. Our empirical setting is an embedded polar case of audience support, the Parmalat case, following a severe CSI scandal. Whilst the adaptive strategies taken to maintain the harmed moral legitimacy were a necessary procedural phase to consent the firms’ survival, they could not be considered sufficient to reintegrate the firm with its main constituent audiences. Essential to the maintaining process was the presence of rational effe…
Issues and Perspectives in the Application of Different Pavement Design Methods to Life Cycle Cost Analysis
2016
Life cycle costs analysis (LCCA) is an economic evaluation tool that can provide valuable guidance to transportation officials in management decision process. The application of LCCA to pavement management is vital because it permits the selection of the best alternative, based on the analysis of agency costs and user costs, taking into account (after selecting pavement type) different maintenance and rehabilitation (M&R) strategies within the same pavement type. Additionally, environmental costs can be considered. Issues arise when comparing the expected life of the pavement derived according to different pavement design tools, such as the Mechanistic-Empirical pavement Design Guide (M…
Treatment of hepatitis C: critical appraisal of the evidence
2005
Chronic hepatitis C virus infection is currently the most common cause of end stage liver disease worldwide. Although the conclusions of the last National Institutes of Health Consensus Development Conferences on Hepatitis C have recently been published, several important issues remain unanswered. This paper reviews the available data using an evidence-based approach. Current evidence is sufficient to recommend IFN treatment for all patients with acute hepatitis. A later initiation of therapy yields the same likelihood of response as early treatment. A daily induction dose during month 1 is the best treatment option. The current gold standard of efficacy for treatment-naive patients with ch…
The role of information and communication technologies in the relationship between group potency and group maintenance outcomes: a longitudinal study
2013
Group potency is one of the major factors influencing work group success. However, little is known about the effects of potency on group maintenance outcomes, especially in virtual teams. The present study examines the moderating role of information and communication technologies ICTs in the relationships between potency and group maintenance outcomes in a longitudinal study. The study involved 44 groups of four members each, working in two communication media: face-to-face F-t-F and computer-mediated communication CMC. The groups developed a project during four weekly sessions over a 1-month period. The results showed that ICTs moderated the relationship between potency and maintenance out…
Cancer in Elderly Onset Inflammatory Bowel Disease: A Population-Based Study.
2016
IF 10.383; International audience; OBJECTIVES: Cancer may be a complication of inflammatory bowel disease (IBD) or its treatment. In elderly onset IBD patients the risk of malignancy is of particular concern. We studied this risk in a population-based cohort of elderly onset IBD patients.METHODS: In a French population-based cohort, we identified 844 patients aged >60 years at IBD diagnosis from 1988 to 2006, including 370 Crohn's disease (CD) and 474 ulcerative colitis (UC). We compared incidence of cancer among IBD patients with that observed in the French Network of population-based Cancer Registries (FRANCIM). Confidence interval (CI) was estimated assuming a Poisson-specific law for ra…
MODELADO DE UNA PLATAFORMA DE E-MANTENIMIENTO, CMMS Y CBM
2014
The information and communications technologies (ICT) are increasingly used in society and business. ICT have become a key element for business development and the improvement of activities in all departments. Analogously, the rise of Computerized Maintenance Management Systems (CMMS), Condition Based Maintenance (CBM), and the use of remote devices and functions such as e-maintenance, have opened great possibilities for maintenance optimization. Those techniques have resulted in the emergence of technological challenges such as interoperability between different systems in order to exchange and coordinate information. In this context, the application of business process modelling is a cruc…