Search results for "maksa"
showing 10 items of 145 documents
Parvovirus B19V Nonstructural Protein NS1 Induces Double-Stranded Deoxyribonucleic Acid Autoantibodies and End-Organ Damage in Nonautoimmune Mice
2018
Abstract Background Viral infection is implicated in development of autoimmunity. Parvovirus B19 (B19V) nonstructural protein, NS1, a helicase, covalently modifies self double-stranded deoxyribonucleic acid (dsDNA) and induces apoptosis. This study tested whether resulting apoptotic bodies (ApoBods) containing virally modified dsDNA could induce autoimmunity in an animal model. Methods BALB/c mice were inoculated with (1) pristane-induced, (2) B19V NS1-induced, or (3) staurosporine-induced ApoBods. Serum was tested for dsDNA autoantibodies by Crithidia luciliae staining and enzyme-linked immunosorbent assay. Brain, heart, liver, and kidney pathology was examined. Deposition of self-antigens…
Activin Receptor Ligand Blocking and Cancer Have Distinct Effects on Protein and Redox Homeostasis in Skeletal Muscle and Liver
2019
Muscle wasting in cancer cachexia can be alleviated by blocking activin receptor type 2 (ACVR2) ligands through changes in protein synthesis/degradation. These changes in cellular and protein metabolism may alter protein homeostasis. First, we elucidated the acute (1–2 days) and 2-week effects of blocking ACVR2 ligands by soluble activin receptor 2B (sACVR2B-Fc) on unfolded protein response (UPR), heat shock proteins (HSPs) and redox balance in a healthy mouse skeletal muscle. Second, we examined UPR, autophagy and redox balance with or without sACVR2B-Fc administration in muscle and liver of C26 tumor-bearing mice. The indicators of UPR and HSPs were not altered 1–2 days after a single sAC…
Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease
2023
Numerous studies have described specific metabolites as biomarkers ofsevere liver diseases, but very few have measured gut microbiota (GM)-produced metab-olites in fatty liver disease. We aimed atfinding GM signatures and metabolite markersin plasma and feces related to high liver fat content. Based on imaging, we dividedstudy participants into low (,5%, LF,n= 25) and high (.5%, HF,n= 39) liver fatgroups. Fecal (LFn= 14, HFn= 25) and plasma (LFn= 11, HFn= 7) metabolomes ofsubsets of participants were studied using liquid chromatography/high resolution massspectrometry. The GM were analyzed using 16S rRNA gene sequencing. Additionally,blood clinical variables and diet were studied. Dyslipide…
Darba samaksas un motivēšanas sistēmas novērtējums un tā pilnveides iespējas Daugavpils pilsētas “X” pirmsskolas izglītības iestādē.
2018
Darba autore: Jūlija Guseļščikova Darba tēma: Darba samaksas un motivēšanas sistēmas novērtējums un tā pilnveides iespējas Daugavpils pilsētas “X” pirmsskolas izglītības iestādē. Darba mērķis ir pētīt darba samaksas un motivēšanas sistēmu iestādē un izstrādāt priekšlikumus tā pilnveidei. Darba mērķa sasniegšanai ir izvirzīti šādi uzdevumi: 1.Izpētīt darba samaksas un motivēšanas sistēmas teorētiskos aspektus, balstoties uz zinātnisko literatūru un LR normatīvajiem dokumentiem. 2.Sniegt iestādes raksturojumu. 3.Izpētīt esošo darba samaksas un motivēšanas sistēmas elementus un to pielietojumu iestādē. 4.Veikt darbinieku attieksmes pret darba samaksas un motivācijas sistēmu iestādē pētījumu (a…
Bioaccumulation of hepatotoxins : A considerable risk in the Latvian environment
2014
Abstract The Gulf of Riga, river Daugava and several interconnected lakes around the City of Riga, Latvia, form a dynamic brackish-freshwater system favouring occurrence of toxic cyanobacteria. We examined bioaccumulation of microcystins and nodularin-R in aquatic organisms in Latvian lakes, the Gulf of Riga and west coast of open Baltic Sea in 2002–2007. The freshwater unionids accumulated toxins efficiently, followed by snails. In contrast, Dreissena polymorpha and most lake fishes (except roach) accumulated much less hepatotoxins. Significant nodularin-R concentrations were detected also in marine clams and flounders. No transfer of nodularin-R and microcystins between lake and brackish …
Exercise and Metformin Intervention Prevents Lipotoxicity-Induced Hepatocyte Apoptosis by Alleviating Oxidative and ER Stress and Activating the AMPK…
2022
Objective. Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) commonly coexist and act synergistically to drive adverse clinical outcomes. This study is aimed at investigating the effects of exercise intervention and oral hypoglycaemic drug of metformin (MET) alone or combined on hepatic lipid accumulation. To investigate if oxidative stress and endoplasmic reticulum stress (ERS) are involved in lipotoxicity-induced hepatocyte apoptosis in diabetic mice and whether exercise and/or MET alleviated oxidative stress or ERS-apoptosis by AMPK-Nrf2-HO-1 signaling pathway. Methods. Forty db/db mice with diabetes ( random blood glucose ≥ 250 mg / dL ) were randomly allocated i…
Using Blockchain in Digitalizing Enterprise Legacy Systems: An Experience Report
2021
Blockchain technology and distributed ledger technology (DLT) offer a secure, distributed, and tamper-proof way to store and exchange information. However, apart from standard cryptocurrency-based networks, innovations and process improvements based on the blockchain technology have mostly remained on the conceptualizing stage and have not yet reached mass adoption. There is a high demand for practical experiences from developing blockchain and DLT based systems in various domains outside FinTech. This work seeks to contribute to this gap by presenting real-world experiences from developing a proof of concept for automatizing conditional payments in social benefits and healthcare domains. W…
Drivers and outcomes of consumer engagement : Insights from mobile money usage in Ghana
2019
Purpose The purpose of this paper is to examine the drivers of consumer engagement and its consequences via the experiences of mobile money services’ users in Ghana and to discuss its implications for the society, financial service innovation, delivery and operations. Design/methodology/approach A pre-tested survey instrument was used with a sample of 595 mobile money services users in Ghana. SmartPLS application was used to analyze the data and report findings. Findings The study shows that perceived risk, consumer empowerment, subjective norm, performance expectancy and effort expectancy influence the affect component of consumer engagement and explain around half of its variance. The ef…
Darba samaksa un darba samaksas sistēmas izpēte uzņēmumā SIA "ABC"
2020
Diplomdarba “DARBA SAMAKSA UN DARBA SAMAKSAS SISTĒMAS IZPĒTE UZŅĒMUMĀ SIA “ABC”” mērķis, pamatojoties uz darba samaksas teorētiskajām atziņām, identificēt normatīvajos aktos un pētāmajā uzņēmumā SIA “ABC” nepilnības un minēt priekšlikumus to novēršanai. Diplomdarbā ir izpētīti Latvijas normatīvie dokumenti, ekonomiskā literatūra, statistiskie dati un uzņēmuma SIA “ABC” nepublicētie materiāli, kā arī veikti praktiski aprēķini. Diplomdarbā izstrādāšanas gaitā autore konstatē, ka darba samaksas sistēma ir cieši saistīta ar likumdošanu un cilvēku izpratni par atalgojumu. Diplomdarba autore konstatēja virkni nepilnību normatīvajos aktos un uzņēmumā SIA “ABC”, un izstrādāja priekšlikumus to novēr…
Uzņēmuma darba organizācijas pilnveidošana finansiālā stāvokļa uzlabošanai
2016
Diplomdarba „Uzņēmuma darba organizācijas pilnveidošana finansiālā stāvokļa uzlabošanai” autors ir studente Ilze Šlapina. Diplomdarbā tika izvērtēta uzņēmuma organizatoriskās struktūras, darbaspēka optimālas izmantošanas un darbaspēka apmaksas ietekme uz uzņēmuma izmaksām un piedāvāti risinājumi, ar kuru palīdzību iespējams uzlabot uzņēmuma finansiālo stāvokli. Diplomdarbs sastāv no trim daļām: uzņēmuma darba organizācijas teorētisks pamatojums, uzņēmuma finansiālais stāvoklis un mērķa sasniegšanas metodes, „Train to nowhere” raksturojums un darba organizācijas pilnveidošana. Diplomdarbs satur 74 lappuses teksta ar 16 attēliem, 13 tabulām un 17 formulām. Darbā izmantoti 38 informācijas avot…