Search results for "malaltia"
showing 10 items of 21 documents
Real‐world evidence of tisagenlecleucel for the treatment of relapsed or refractory large B‐cell lymphoma
2021
Abstract Tisagenlecleucel (tisa‐cel) is a second‐generation autologous CD19‐targeted chimeric antigen receptor (CAR) T‐cell therapy approved for relapsed/refractory (R/R) large B‐cell lymphoma (LBCL). The approval was based on the results of phase II JULIET trial, with a best overall response rate (ORR) and complete response (CR) rate in infused patients of 52% and 40%, respectively. We report outcomes with tisa‐cel in the standard‐of‐care (SOC) setting for R/R LBCL. Data from all patients with R/R LBCL who underwent leukapheresis from December 2018 until June 2020 with the intent to receive SOC tisa‐cel were retrospectively collected at 10 Spanish institutions. Toxicities were graded accor…
Cryptic Insertions Of The Immunoglobulin Light Chain Enhancer Region Near CCND1 In T(11;14)-Negative Mantle Cell Lymphoma
2019
Cyclin D1+ mantle cell lymphoma (MCL) is molecularly characterized by the t(11;14)(q13;q32) or rearrangements of CCND1 gene with the immunoglobulin (IG) light chains.1,2 Most MCL can be diagnosed based on the characteristic pathologic features and cyclin D1 expression without the need for demonstrating the genetic translocation. However, in cases with atypical morphologic or phenotypic features other B-cell neoplasms that sometimes also have cyclin D1 positivity may be in the differential diagnosis.1 In these situations the detection of the CCND1 rearrangements may assist in the diagnosis since most other lymphomas do not carry translocations of the gene.3-7 A subset of plasma cell myelomas…
Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact…
2022
Funder: European society of Intensive Care Medicine
A cross-sectional and longitudinal study on the protective effect of bilingualism against dementia using brain atrophy and cognitive measures.
2020
Abstract Background Evidence from previous studies suggests that bilingualism contributes to cognitive reserve because bilinguals manifest the first symptoms of Alzheimer’s disease (AD) up to 5 years later than monolinguals. Other cross-sectional studies demonstrate that bilinguals show greater amounts of brain atrophy and hypometabolism than monolinguals, despite sharing the same diagnosis and suffering from the same symptoms. However, these studies may be biased by possible pre-existing between-group differences. Methods In this study, we used global parenchymal measures of atrophy and cognitive tests to investigate the protective effect of bilingualism against dementia cross-sectionally …
A genome-wide association study of marginal zone lymphoma shows association to the HLA region
2015
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10−15) and HLA-B (rs2922994, P=2.43 × 10−9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
Occupation and Risk of Non-Hodgkin Lymphoma and Its Subtypes: A Pooled Analysis from the InterLymph Consortium
2016
Background: Various occupations have been associated with an elevated risk of non-Hodgkin lymphoma (NHL), but results have been inconsistent across studies. Objectives: We investigated occupational risk of NHL and of four common NHL subtypes with particular focus on occupations of a priori interest. Methods: We conducted a pooled analysis of 10,046 cases and 12,025 controls from 10 NHL studies participating in the InterLymph Consortium. We harmonized the occupational coding using the 1968 International Standard Classification of Occupations (ISCO-1968) and grouped occupations previously associated with NHL into 25 a priori groups. Odds ratios (ORs) adjusted for center, age, and sex were det…
Determination of neuronal antibodies in suspected and definite Creutzfeldt-Jakob disease
2014
IMPORTANCE: Creutzfeldt-Jakob disease (CJD) and autoimmune encephalitis with antibodies against neuronal surface antigens (NSA-abs) may present with similar clinical features. Establishing the correct diagnosis has practical implications in the management of care for these patients. OBJECTIVE: To determine the frequency of NSA-abs in the cerebrospinal fluid of patients with suspected CJD and in patients with pathologically confirmed (ie, definite) CJD. DESIGN, SETTING, AND PARTICIPANTS: A mixed prospective (suspected) and retrospective (definite) CJD cohort study was conducted in a reference center for detection of NSA-abs. The population included 346 patients with suspected CJD and 49 pati…
Entre l’estigma i la frivolitat: El Dia Mundial del Càncer en la premsa espanyola
2013
El càncer és un tema d’interès destacat per a la ciutadania. Els mitjans de comunicació, en tant que reflex i alhora conformadors de valors socials, transmeten una visió de la malaltia que no sempre és la més acurada i clarificadora. En aquest article s’analitza la repercussió mediàtica durant la darrera dècada del Dia Mundial del Càncer als quatre diaris d’informació general amb major difusió a Espanya. L’objectiu és estudiar de quina manera es fa ús de l’efemèride per a oferir informació relativa a la malaltia i si el tractament informatiu és precís i rigorós o cau en l’estereotip i el sensacionalisme.
Centre d'Educació Especial Auxilia. Un model d'atenció acadèmica domiciliària
2011
This article describes a pioneering experience in education - Auxilia Centre for Special Education. This centre provides continuity for the education of children affected by physical disabilities, chronic illness or psychiatric illness and who, because of their illness, are forced to stay at home for certain periods without being able to assume standardized travel to the school at which they are enrolled. The Centre gives them personal and individualized academic service at home to enable their development.
Malaltia i salut en l'obra de Francesc Eiximenis
2010
Diversos autors han analitzat els voluminosos tractats de Francesc Eiximenis, especialment pel que fa a matèries relacionades amb la teologia moral, però també sobre altres temes, com la guerra i la pau, l’astrologia, el govern, la cuina i el menjar, i d’altres. En aquest article ens proposem apropar-nos a com Eiximenis tracta el tema dels hospitals, medicina, salut i malaltia. Eiximenis es preocupava de les necessitats del poble que sofria tot tipus de malalties; a part d’haver viscut durant diverses epidèmies, que provocà moltes morts a la península, també suggerí als jurats de València un bon sistema d’hospitals i on s’haurien de construir, i també els cridà l’atenció respecte de les def…