Search results for "man studie"
showing 10 items of 35 documents
MicroRNAs and periodontal disease: a qualitative systematic review of human studies.
2020
Purpose MicroRNAs (miRNAs) are epigenetic post-transcriptional regulators that modulate gene expression and have been identified as biomarkers for several diseases, including cancer. This study aimed to systematically review the relationship between miRNAs and periodontal disease in humans, and to evaluate the potential of miRNAs as diagnostic and prognostic biomarkers of disease. Methods The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines (reference number CRD42020180683). The MEDLINE, Scopus, Cochrane Library, Embase, Web of Science, and SciELO databases were searched for clinical studies conducted in humans investigating pe…
In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration
2019
The availability of in vitro tools that are constructed on the basis of a detailed knowledge of key aspects of gastrointestinal (GI) physiology and their impact on formulation performance and subsequent drug release behaviour is fundamental to the success and efficiency of oral drug product development. Over the last six years, the development and optimization of improved, biorelevant in vitro tools has been a cornerstone of the IMI OrBiTo (Oral Biopharmaceutics Tools) project. By bringing together key industry and academic partners, and by linking tool development and optimization to human studies to understand behaviour at the formulation/GI tract interface, the collaboration has enabled …
Neue Wege der Germanistik: International, Transdisziplinär, Digital
2020
Der Band bietet einen Überblick über die gegenwärtige Rolle des Fachs Germanistik im Kontext der Globalisierung und Digitalisierung unserer Welt . Der Frage nach dem künftigen, aus dem gegenwärtigen Wechselspiel zwischen traditionellen und neuen Impulsen entstehenden Profil der germanis-tischen Lehre und Forschung ist dabei nachgegangen worden. Die Arbeit hat für diesen Kontext wichtige Ergebnisse hervorgebracht, die sich aus den Beiträgen ergeben, in denen verschiedene Aspekte des Fragenkomplexes fokussiert und diskutiert werden konnten, u. a. die Auswirkung neuer, transdisziplinärer Ansätze; die Auseinandersetzung mit gesellschaftsrelevanten Forschungsgegenständen; der Input der…
Safety and side effects of human and ovine corticotropin-releasing hormone administration in man.
1991
Synthetic human and ovine corticotropin-releasing hormone (hCRH, oCRH) are commonly used as a diagnostic tool of the hypothalamo-pituitary-adrenal axis. In this paper reports about side effects after various modes of CRH-application are analyzed and compared to our corresponding data of human studies with hCRH and oCRH. Generally, CRH is well tolerated after single administration and interval-application of standard doses, although minor side effects appear sometimes after higher doses (greater than 200 micrograms hCRH, oCRH) of CRH-bolus-injections. Predominantly the cardiovascular system (e.g. tachycardia, hypotension, flushing) is affected; neuropsychological symptoms are only seen spora…
Immediate implants placed in fresh sockets associated to periapical infectious processes: a systematic review
2013
Objetives: The development of treated implant surfaces, added to the increase of the aesthetic requirements by the patients has led to a change in the treatment protocols as well as the development of techniques such as the onefase implants and the immediate prosthetic loading. One of the usual contraindications of the implant treatment is the presence of periapical disease associated to the tooth to be replaced. The aim of this paper is to review the published literature on immediate implant placement in extraction sockets of teeth with periapical pathology, considering the level of scientific evidence, and following the principles of medicine and evidence-based Dentistry. Material and Met…
Perceptual Interactions in Complex Odor Mixtures
2014
The perception of everyday odors relies on elemental or configural processing of complex mixtures of odorants. Theoretically, the configural processing of a mixture could lead to the perception of a single specific odor for the mixture; however, such a type of perception has hardly been proven in human studies. Here, we report the results of a sorting task demonstrating that a six-component mixture carries an odor clearly distinct from the odors of its components. These results suggest a blending effect of individual components’ odors in mixtures containing more than three odorants.
[35] Determination of oxidized glutathione in blood: High-performance liquid chromatography
1994
Publisher Summary The measurement of glutathione status is important in determining oxidative stress in tissues and biological fluids. The ratio of reduced to oxidized glutathione (GSH/GSSG) is a good indicator of the oxidative stress that may occur under physiological and pathological conditions. Changes in GSSG levels have been considered as intracellular signals able to modulate enzyme activity. Thus, it is important to have accurate methods to determine GSSG in biological fluids and in cells. In many cases, it is possible to use tissues, such as liver, muscle, or brain to determine GSH/GSSG. However, especially in human studies, samples from these tissues are not readily available; the …
Recensione di Ilona Zsolnay (ed.), Being a Man: Negotiating Ancient Constructs of Masculinity
2021
Gut Microbiota, Obesity and Bariatric Surgery: Current Knowledge and Future Perspectives.
2019
Background::There is an urgent need for a better understanding and management of obesity and obesity- associated diseases. It is known that obesity is associated with structural and functional changes in the microbiome.Methods::The purpose of this review is to present current evidence from animal and human studies, demonstrating the effects and the potential efficacy of microbiota modulation in improving obesity and associated metabolic dysfunctions.Results::This review discusses possible mechanisms linking gut microbiota dysbiosis and obesity, since there is a dual interaction between the two of them. Furthermore, comments on bariatric surgery, as a favourable model to understand the under…