Search results for "marca"
showing 10 items of 252 documents
Urinary 1H Nuclear Magnetic Resonance Metabolomic Fingerprinting Reveals Biomarkers of Pulse Consumption Related to Energy-Metabolism Modulation in a…
2017
Little is known about the metabolome fingerprint of pulse consumption. The study of robust and accurate biomarkers for pulse dietary assessment has great value for nutritional epidemiology regarding health benefits and their mechanisms. To characterize the fingerprinting of dietary pulses (chickpeas, lentils and beans), spot urine samples from a subcohort from the PREDIMED study were stratified, using a validated food frequency questionnaire. Non-pulse consumers (≤ 4 g/day of pulse intake) and habitual pulse consumers (≥ 25 g/day of pulse intake) were analysed using a 1H-NMR metabolomics approach combined with multi- and univariate data analysis. Pulse consumption showed differences through…
Dynamics and predicted drug response of a gene network linking dedifferentiation with β-catenin dysfunction in hepatocellular carcinoma
2019
Background & Aims Alterations of individual genes variably affect the development of hepatocellular carcinoma (HCC). Thus, we aimed to characterize the function of tumor-promoting genes in the context of gene regulatory networks (GRNs). Methods Using data from The Cancer Genome Atlas, from the LIRI-JP (Liver Cancer – RIKEN, JP project), and from our transcriptomic, transfection and mouse transgenic experiments, we identify a GRN which functionally links LIN28B-dependent dedifferentiation with dysfunction of β-catenin (CTNNB1). We further generated and validated a quantitative mathematical model of the GRN using human cell lines and in vivo expression data. Results We found that LIN28B and C…
Advances in Integrating Traditional and Omic Biomarkers When Analyzing the Effects of the Mediterranean Diet Intervention in Cardiovascular Prevention
2016
Intervention with Mediterranean diet (MedDiet) has provided a high level of evidence in primary prevention of cardiovascular events. Besides enhancing protection from classical risk factors, an improvement has also been described in a number of non-classical ones. Benefits have been reported on biomarkers of oxidation, inflammation, cellular adhesion, adipokine production, and pro-thrombotic state. Although the benefits of the MedDiet have been attributed to its richness in antioxidants, the mechanisms by which it exercises its beneficial effects are not well known. It is thought that the integration of omics including genomics, transcriptomics, epigenomics, and metabolomics, into studies a…
Phase Ib study evaluating safety and clinical activity of the anti-HER3 antibody lumretuzumab combined with the anti-HER2 antibody pertuzumab and pac…
2018
Summary Purpose To investigate the safety and clinical activity of comprehensive human epidermal growth factor receptor (HER) family receptor inhibition using lumretuzumab (anti-HER3) and pertuzumab (anti-HER2) in combination with paclitaxel in patients with metastatic breast cancer (MBC). Methods This phase Ib study enrolled 35 MBC patients (first line or higher) with HER3-positive and HER2-low (immunohistochemistry 1+ to 2+ and in-situ hybridization negative) tumors. Patients received lumretuzumab (1000 mg in Cohort 1; 500 mg in Cohorts 2 and 3) plus pertuzumab (840 mg loading dose [LD] followed by 420 mg in Cohorts 1 and 2; 420 mg without LD in Cohort 3) every 3 weeks, plus paclitaxel (8…
CD5 and CD6 as immunoregulatory biomarkers in non-small cell lung cancer
2020
Background: The study of immune surveillance in the tumour microenvironment is leading to the development of new biomarkers and therapies. The present research focuses on the expression of CD5 and CD6-two lymphocyte surface markers involved in the fine tuning of TCR signaling-as potential prognostic biomarkers in resectable stages of non-small cell lung cancer (NSCLC).; Methods: CD5 and CD6 gene expression was analysed by reverse transcription quantitative polymerase chain reaction (RTqPCR) in 186 paired fresh frozen tumour and normal tissue samples of resected NSCLC.; Results: Patients with higher CD5 expression had significantly increased overall survival (OS, 49.63 vs. 99.90 months, P=0.…
Trajectories of stress biomarkers and anxious-depressive symptoms from pregnancy to postpartum period in women with a trauma history
2019
Background: Cross-sectional studies have found that a trauma history can be associated with anxious-depressive symptomatology and physiological stress dysregulation in pregnant women. Methods: This prospective study examines the trajectories of both anxiety and depressive symptoms and salivary cortisol and alpha-amylase biomarkers from women with (n = 42) and without (n = 59) a trauma history at (i) 38th week of gestation (T1), (ii) 48 hours after birth (T2), and (iii) three months after birth (T3). Results: The quantile regression model showed that trauma history was associated with higher cortisol levels at T1 and this difference was sustained along T2 and T3. Conversely, there were no si…
Marcadores citogenéticos aplicados en biomedicina = Cytogentic biomarkers applied in biomedicine
2013
Cuando se pretende identificar una determinada exposición a una sustancia exógena al organismo se utilizan biomarcadores que nos permitan confirmar esta exposición. En el caso de que la exposición provoque un efecto nocivo en el material genético, el interés se centra en biomarcadores genotóxicos. Si el efecto en el material genético se traduce en cambios en la estructura o en el número de cromosomas observables y cuantificables mediante técnicas citogenéticas, estos cambios se podrán emplear como biomarcadores citogenéticos. De hecho, los biomarcadores citogenéticos son criterios de valoración frecuentemente utilizados en estudios poblacionales. Su sensibilidad para la medición de exposici…
Marcas turísticas y territorio : Un análisis geográfico del turismo valenciano
2002
-Emili.Obiol@uv.es Este trabajo tiene por objetivo analizar las relaciones territoriales existentes en las marcas turísticas zonales del País Valenciano. Interesará ver cómo la geografía es la gran abastecedora de los componentes básicos de una marca turística, de modo que los logotipos y elementos de ésta coinciden con los recursos territoriales turísticos más significativos de aquella. Se estudiarán especialmente los casos de las marcas turísticas «Costa Azahar», «Mediterrània » y «Valencia, terra y mar». En ellas se analizarán también sus orígenes, estrategias turísticas y de márketing y sus vicisitudes de gestión. Aspectos importantes serán asimismo la conveniencia o no de la presencia …
Hornos, marcas..y más allá
2014
Las ánforas ibéricas tienen unos atributos morfológicos poco normalizados a lo largo del tiempo, lo que ha dificultado establecer una tipología detallada, reconocer los lugares de producción, los posibles contenidos y los circuitos de distribución. Para avanzar en alguna de estas problemáticas, proponemos explorar una nueva vía: las marcas que portan algunos de estos contenedores. Su distribución geográfica y cronológica es amplia, pero se detectan concentraciones significativas a nivel territorial y en determinados yacimientos, ya sean centros alfareros o núcleos distribuidores/receptores, así como diseños repetidos. Las marcas precocción, incisas e impresas, se plasman en la alfarería con…
Reformulación y categorías vecinas: un tratamiento teórico-experimental a través del marcador discursivo o sea en español = Reformulation and neighbo…
2019
Recientemente, los estudios sobre reformulación han generado un debate teórico en torno a esta función y su tratamiento semasiológico-onomasiológico: algunos autores abogan por una distinción clara de esta función frente a otras, como la conclusión o la corrección (Pons 2013, 2017). Otros autores defienden que la reformulación presenta subtipos basados en esas otras funciones, expresadas por los mismos marcadores discursivos: los reformuladores (Murillo 2016). La primera postura va de lo onomasiológico a lo semasiológico: la reformulación, la paráfrasis, la conclusión y la corrección son cuatro relaciones discursivas diferenciables (Pons 2013) que pueden expresarse a través de los mismos ma…