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RESEARCH PRODUCT
Trajectories of stress biomarkers and anxious-depressive symptoms from pregnancy to postpartum period in women with a trauma history
Ana García BlancoBelén AlmansaRosa Sahuquillo-lealElena Serrano-lozanoAlba Moreno-giménezFarah GhosnConsuelo Cháfer-pericásMáximo VentoVicente DiagoDavid Hervássubject
050103 clinical psychologyembarazolcsh:RC435-571depresión抑郁Trauma怀孕Ansiedad03 medical and health sciences0302 clinical medicinelcsh:Psychiatrystress biomarkersmedicine0501 psychology and cognitive sciencespostpartum• Follow-up study on pregnant women with a trauma history. •Data analysed by quantile and ordinal regression models.•Trauma history and high cortisol levels from pregnancy to postpartum. • High α-amylase levels during postpartum period regardless of a trauma history. • Trauma history and high anxious symptoms from late pregnancy to childbirth.Physiological stressDepression (differential diagnoses)Depressive symptoms产后Clinical Research ArticlePregnancybiomarcadores de estrésbusiness.industryfungi05 social sciences焦虑food and beveragesanxietymedicine.diseasepostparto030227 psychiatrytraumaStress biomarkersdepressionAnxietypregnancymedicine.symptombusiness创伤Postpartum period应激生物标志物Clinical psychologydescription
Background: Cross-sectional studies have found that a trauma history can be associated with anxious-depressive symptomatology and physiological stress dysregulation in pregnant women. Methods: This prospective study examines the trajectories of both anxiety and depressive symptoms and salivary cortisol and alpha-amylase biomarkers from women with (n = 42) and without (n = 59) a trauma history at (i) 38th week of gestation (T1), (ii) 48 hours after birth (T2), and (iii) three months after birth (T3). Results: The quantile regression model showed that trauma history was associated with higher cortisol levels at T1 and this difference was sustained along T2 and T3. Conversely, there were no significant differences in alpha-amylase levels between groups across the three time points and both groups showed an increase in alpha-amylase levels from T2 to T3. The ordinal mixed model showed that trauma history was associated with higher anxiety symptoms at T1 and this remained constant from T1 to T2 but was reversed from T2 to T3. In contrast, both groups showed similar depressive symptoms across the three time points. Conclusions: Whereas physiological stress dysregulation (in terms of higher cortisol levels) was maintained from pregnancy to postpartum period, pregnancy and childbirth were the most vulnerable stages for developing anxious symptoms in mothers with trauma history.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-07 | European Journal of Psychotraumatology |