Search results for "maximum"
showing 10 items of 753 documents
“Weekly docetaxel and gemcitabine as first line treatment for metastatic breast cancer: results of a multicenter phase II study”
2004
<i>Objectives:</i> We conducted a multicenter phase II study to evaluate the clinical efficacy, toxicity, and dose intensity of a new weekly schedule of docetaxel and gemcitabine as first-line treatment of metastatic breast cancer patients. <i>Methods:</i> We enrolled 58 patients, 52% of whom had received a previous anthracycline-containing chemotherapy. The treatment schedule was: docetaxel 35 mg/m<sup>2</sup> and gemcitabine 800 mg/m<sup>2</sup> i.v. on days 1, 8, 15 every 28 days. <i>Results:</i> All patients were assessable for toxicity and 56 for efficacy. Overall response rate was 64.3% with 16.1% of complete responses and 48…
TRIPLET SCHEDULE OF WEEKLY 5-FLUOROURACIL AND ALTERNATING IRINOTECAN OR OXALIPLATIN IN ADVANCED COLORECTAL CANCER: A DOSE-FINDING AND PHASE II STUDY.
2010
A weekly administration of alternating irinotecan or oxaliplatin associated to 5-Fluorouracil in advanced colorectal cancer was planned in order to evaluate a new schedule maintaining dose intensities of each drug as in double combinations and tolerability of the triplet association. The following weekly schedule was administered: irinotecan, days 1 and 15; oxaliplatin, days 8 and 22; 5-fluorouracil (5-FU) over 12-h (from 10:00 p.m. to 10:00 a.m.) timed flat infusion, days 1-2, 8-9, 15-16 and 22-23, every 4 weeks. Dose- finding and phase II study were planned. Thirteen patients were enrolled in the dose-finding study and 23 in the phase II study. The recommended doses of our study are: irin…
Pertuzumab monotherapy after trastuzumab-based treatment and subsequent reintroduction of trastuzumab: activity and tolerability in patients with adv…
2012
Purpose The combination of pertuzumab and trastuzumab resulted in a clinical benefit rate (CBR) of 50% in patients with human epidermal growth factor receptor 2 (HER2) –positive breast cancer whose disease progressed during prior trastuzumab-based therapy. To define whether this previously observed encouraging activity was a result of the combination of pertuzumab and trastuzumab or of pertuzumab alone, we recruited a third cohort of patients who received pertuzumab without trastuzumab. We then investigated the impact of reintroducing trastuzumab to patients whose disease progressed on pertuzumab monotherapy. Patients and Methods Twenty-nine patients with HER2-positive breast cancer whose d…
Phase I Study of Definitive Radio-chemotherapy with Cisplatin, 5-Fluorouracil and Cetuximab for Unresectable Locally Advanced Esophageal Cancer.
2017
Background/aim Prognoses of patients receiving radio-chemotherapy with 5-fluorouracil (5-FU) and cisplatin for unresectable esophageal cancer may be improved with the addition of cetuximab. This phase I study aimed to define the maximum tolerated dose of 5-FU when combined with cisplatin, cetuximab and radiotherapy. Patients and methods Treatment included 59.4 Gy of radiotherapy concurrently with two courses of cisplatin (20 mg/m2, d1-4) and 5-FU (dose level 0: 500 mg/m2, dose level 1: 750 mg/m2, d1-4; dose level 2: 1,000 mg/m2, d1-4), followed by two courses of chemotherapy. Cetuximab was given for 14 weeks (400 mg/m2 loading dose followed by 250 mg/m2 weekly). Results At dose level 1 (n=3…
Performance improvement of a novel combined water turbine
2020
Abstract Nowadays, industrials and researchers are looking for renewable energy resources due to the increase of energy demand. Recently, the ability of combined turbines in harnessing energy from water current has increased their renewed interest. However, there still exist a big knowledge gap to select the optimal design of these turbines. In this paper, systematic studies of stand-alone helical Savonius and delta bladed Darrieus turbines were carried out using experimental methods as a precursor to analyze their roles in hybrid configuration. By varying the attachment angle, two hybrid configurations were tested experimentally. Using the optimal attachment angle, six hybrid configuration…
A Bayesian Learning Automaton for Solving Two-Armed Bernoulli Bandit Problems
2008
The two-armed Bernoulli bandit (TABB) problem is a classical optimization problem where an agent sequentially pulls one of two arms attached to a gambling machine, with each pull resulting either in a reward or a penalty. The reward probabilities of each arm are unknown, and thus one must balance between exploiting existing knowledge about the arms, and obtaining new information. In the last decades, several computationally efficient algorithms for tackling this problem have emerged, with learning automata (LA) being known for their ?-optimality, and confidence interval based for logarithmically growing regret. Applications include treatment selection in clinical trials, route selection in …
Optimal Integration of Hybrid Supercapacitor and IPT System for a Free-Catenary Tramway
2019
The aim of the paper is the study of an optimal integration of a supercapacitor-based storage system and inductive power transfer system for the free-catenary operation of a tramway. Starting from the definition of the topology of inductive power transfer system, we propose and analyze a design procedure for the pads of the inductive power system. In the second part of the paper, an optimal integration strategy for the correct size of on-board supercapacitors and the power of the inductive energy transfer are proposed. The results obtained by means of numerical simulations are discussed. © 2018 IEEE.
Comparison of Numerical Methods in the Contrast Imaging Problem in NMR
2013
International audience; In this article, the contrast imaging problem in nuclear magnetic resonance is modeled as a Mayer problem in optimal control. A first synthesis of locally optimal solutions is given in the single-input case using geometric methods based on Pontryagin's maximum principle. We then compare these results using direct methods and a moment-based approach, and make a first step towards global optimality. Finally, some preliminary results are given in the bi-input case.
Neoendemic ground beetles and private tree haplotypes: two independent proxies attest a moderate last glacial maximum summer temperature depression o…
2011
Abstract Previous findings regarding the Last Glacial Maximum LGM summer temperature depression (maxΔT in July) on the Tibetan Plateau varied over a large range (between 0 and 9 °C). Geologic proxies usually provided higher values than palynological data. Because of this wide temperature range, it was hitherto impossible to reconstruct the glacial environment of the Tibetan Plateau. Here, we present for the first time data indicating that local neoendemics of modern species groups are promising proxies for assessing the LGM temperature depression in Tibet. We used biogeographical and phylogenetic data from small, wingless edaphous ground beetles of the genus Trechus , and from private junip…
Variations in the size of focal nodular hyperplasia on magnetic resonance imaging
2013
Abstract Objective To evaluate the changes in the size of focal nodular hyperplasia (FNH) during long-term magnetic resonance imaging (MRI) follow-up. Material and methods We reviewed 44 FNHs in 30 patients studied with MRI with at least two MRI studies at least 12 months apart. We measured the largest diameter of the lesion (in mm) in contrast-enhanced axial images and calculated the percentage of variation as the difference between the maximum diameter in the follow-up and the maximum diameter in the initial study. We defined significant variation in size as variation greater than 20%. We also analyzed predisposing hormonal factors. Results The mean interval between the two imaging studie…