Search results for "mediator"

showing 10 items of 339 documents

TpF1 from Treponema pallidum Activates Inflammasome and Promotes the Development of Regulatory T Cells

2011

Abstract Human syphilis is a multistage disease, with diverse and wide-ranging manifestations caused by Treponema pallidum. Despite the fact that a cell-mediated immune response takes part in the course of syphilis, T. pallidum often manages to evade host immunity and, in untreated individuals, may trigger chronic infection. With this study, we demonstrate for the first time, to our knowledge, that Treponema pallidum induces a regulatory T (Treg) response in patients with secondary syphilis and we found that the miniferritin TpF1, produced by the bacterium, is able to expand this response and promote the production of TGF-β. Accordingly, TpF1 stimulates monocytes to release IL-10 and TGF-β,…

AdultMaleMultiprotein complexInflammasomesVirulence FactorsCellsT-LymphocytesImmunologyAdult; Antigens Helminth; Cell Differentiation; Cells Cultured; Down-Regulation; Female; Humans; Inflammasomes; Inflammation Mediators; Male; Middle Aged; Monocytes; Syphilis; T-Lymphocytes Regulatory; Transforming Growth Factor beta; Treponema pallidum; Virulence FactorsDown-RegulationBiologyT-Lymphocytes RegulatoryMonocytesMicrobiologyProinflammatory cytokineImmune systemAntigenTransforming Growth Factor betaHelminthmedicineHumansImmunology and AllergySyphilisTreponema pallidumAntigensCells CulturedCulturedTreponemaCell DifferentiationInflammasomeMiddle Agedbiology.organism_classificationmedicine.diseaseRegulatoryChronic infectionAntigens HelminthImmunologyFemaleSyphilisInflammation Mediatorsmedicine.drugThe Journal of Immunology
researchProduct

Oxidative stress and inflammation in long-term renal transplanted hypertensives.

2006

INTRODUCTION Several studies have shown that chronic renal failure (CRF) is characterized by "accelerated atherosclerosis". More recent studies emphasize that inflammation and oxidative stress play a central role in atherosclerosis, and it is well-established that C-reactive protein (CRP) is a cardiovascular risk marker in the general population, in end-stage renal disease (ESRD) patients and in allograft recipients. METHODS We measured the serum concentration of high sensitivity CRP, TNFalpha, 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha, an in vivo oxidative stress marker) in 15 CRF patients and in 15 transplant recipients. Exclusion criteria were age 65 years, smoking, diabetes mellitus …

AdultMaleNephrologymedicine.medical_specialtyTime FactorsPopulationRenal functionDinoprostchemistry.chemical_compoundInternal medicineDiabetes mellitusmedicineHumanseducationeducation.field_of_studyCreatinineTumor Necrosis Factor-alphabusiness.industryGeneral MedicineMiddle Agedmedicine.diseaseKidney Transplantationoxidative stress inflammation hypertension renal transplantationTransplantationOxidative StressC-Reactive ProteinEndocrinologyBlood pressurechemistryNephrologyCase-Control StudiesHypertensionKidney Failure ChronicInflammation MediatorsbusinessKidney disease
researchProduct

Serum Levels of Soluble CD23 in Patients with Asthma or Rhinitis Monosensitive to Parietaria. Its Relation to Total Serum IgE levels and Eosinophil C…

1999

The diagnostic value for allergies of the low affinity IgE receptor and its soluble circulating fragment (sCD23) remains unclear. In particular, little is know about seasonal influences on serum sCD23 levels in subjects with pollen allergy. In the present study, to gain insight into pathophysiological role of sCD23, we have analyzed, in blood from patients allergic to Parietaria sCD23, IgE, and eosinophil cationic protein (ECP) serum levels. IgE were assessed as atopy markers and ECP as an inflammation marker. Patients were studied during and out of pollen season, and results were compared to those obtained in nonallergic subjects. The study population included 42 nonsmoking outpatients, li…

AdultMalePulmonary and Respiratory MedicineAllergyParietariaAdolescentImmunoglobulin EAtopyRibonucleasesHumansImmunology and AllergyMedicinePlant ProteinsAsthmaEosinophil cationic proteinbiologyReceptors IgEbusiness.industryCD23Rhinitis Allergic SeasonalBlood ProteinsGeneral MedicineAllergensEosinophil Granule ProteinsImmunoglobulin EMiddle Agedmedicine.diseasebiology.organism_classificationAsthmaSolubilityImmunologybiology.proteinPollenPopulation studyFemaleImmunizationInflammation MediatorsbusinessAllergy and Asthma Proceedings
researchProduct

Asthma control in severe asthmatics under treatment with omalizumab: A cross-sectional observational study in Italy

2015

Few data are available on the proportion of asthmatics achieving a good asthma control (according GINA guidelines) and on the level of airway inflammation during omalizumab treatment. The aim of this cross-sectional national observational study was to assess the level of control (according to GINA guidelines) achieved in a group of asthmatics on omalizumab treatment, and to characterize the factors that influence the lack of control. We studied 306 asthmatics under omalizumab treatment for a median of 32 months (range 4-120). The level of control according to GINA was good in 25.2%, partial in 47.1% and poor in 24.5% of patients (data were missing for the remaining 3.2%). Comparison between…

AdultMalePulmonary and Respiratory Medicinemedicine.medical_specialtyExacerbationCross-sectional studyOmalizumabOmalizumabComorbiditySettore MED/10 - Malattie Dell'Apparato RespiratorioExhaled nitric oxide; Exacerbations; Comorbidities; Asthma; Omalizumab; ControlSeverity of Illness IndexComorbiditiesExacerbationsExhaled nitric oxideInternal medicineSeverity of illnessControlMedicineAnti-Asthmatic AgentHumansPharmacology (medical)Anti-Asthmatic AgentsInflammation MediatorAsthmaRespiratory Function TestAgedCross-Sectional Studiebusiness.industryBiochemistry (medical)ExacerbationMiddle Agedmedicine.diseaseComorbidityAsthmaRespiratory Function TestsCross-Sectional StudiesItalyExhaled nitric oxidePhysical therapyObservational studyAsthma; Comorbidities; Control; Exacerbations; Exhaled nitric oxide; Omalizumab; Adult; Aged; Anti-Asthmatic Agents; Asthma; Comorbidity; Cross-Sectional Studies; Female; Humans; Inflammation Mediators; Italy; Male; Middle Aged; Omalizumab; Respiratory Function Tests; Severity of Illness Index; Pulmonary and Respiratory Medicine; Biochemistry (medical); Pharmacology (medical)FemaleComorbiditieInflammation Mediatorsbusinessmedicine.drugHuman
researchProduct

Low testosterone levels are related to oxidative stress, mitochondrial dysfunction and altered subclinical atherosclerotic markers in type 2 diabetic…

2017

Abstract Introduction Low testosterone levels in men are associated with type 2 diabetes and cardiovascular risk. However, the role of testosterone in mitochondrial function and leukocyte-endothelium interactions is unknown. Our aim was to evaluate the relationship between testosterone levels, metabolic parameters, oxidative stress, mitochondrial function, inflammation and leukocyte-endothelium interactions in type 2 diabetic patients. Materials and methods The study was performed in 280 male type 2 diabetic patients and 50 control subjects. Anthropometric and metabolic parameters, testosterone levels, reactive oxygen species (ROS) production, mitochondrial membrane potential, TNFα, adhesio…

AdultMaleRiskMitochondrial ROSmedicine.medical_specialtyApolipoprotein BVascular Cell Adhesion Molecule-1030209 endocrinology & metabolismInflammationType 2 diabetes030204 cardiovascular system & hematologyMitochondrionmedicine.disease_causeBiochemistry03 medical and health sciences0302 clinical medicinePhysiology (medical)Internal medicineLeukocytesmedicineHumansTestosteroneMembrane Potential Mitochondrialchemistry.chemical_classificationReactive oxygen speciesbiologyTestosterone (patch)Middle AgedAtherosclerosismedicine.diseaseMitochondriaOxidative StressEndocrinologyDiabetes Mellitus Type 2chemistrybiology.proteinCytokinesInflammation Mediatorsmedicine.symptomReactive Oxygen SpeciesBiomarkersOxidative stressFree Radical Biology and Medicine
researchProduct

Psychophysics, flare, and neurosecretory function in human pain models: capsaicin versus electrically evoked pain.

2007

Intradermal capsaicin injection (CAP) and electrical current stimulation (ES) are analyzed in respect to patterns and test-retest reliability of pain as well as sensory and neurosecretory changes. In 10 healthy subjects, 2 CAP (50 g) and 2 ES (5 to 30 mA) were applied to the volar forearm. The time period between 2 identical stimulations was about 4 months. Pain ratings, areas of mechanical hyperalgesia, and allodynia were assessed. The intensity of sensory changes was quantified by using quantitative sensory testing. Neurogenic flare was assessed by using laser Doppler imaging. Calcito- nin gene-related peptide (CGRP) release was quantified by dermal microdialysis in combination with an en…

AdultMaleTime FactorsSensory Receptor CellsCalcitonin Gene-Related PeptideModels NeurologicalPainStimulationSensory systemCalcitonin gene-related peptidechemistry.chemical_compoundmedicineNoxious stimulusLaser-Doppler FlowmetryPsychophysicsHumansPain MeasurementSkinNerve Fibers UnmyelinatedNeuronal Plasticitybusiness.industryNociceptorsMiddle AgedNeurosecretory SystemsElectric StimulationPeripheralAnesthesiology and Pain MedicineAllodyniaNeurologychemistryCapsaicinHyperalgesiaRegional Blood FlowAnesthesiaHyperalgesiaFemaleNeurology (clinical)medicine.symptomCapsaicinInflammation MediatorsbusinessThe journal of pain
researchProduct

Relaxin in Obstructive Sleep Apnea: Relationship with Blood Pressure and Inflammatory Mediators

2015

<b><i>Background:</i></b> Obstructive sleep apnea (OSA) is associated with nocturnal intermittent hypoxia, which may be responsible for increased circulating levels of vascular endothelial growth factor (VEGF) and inflammatory mediators, such as metalloproteinases (MMPs), and which contributes to the pathogenesis of systemic hypertension. Why some OSA patients remain normotensive is poorly understood. Relaxin-2, a pregnancy hormone, may sometimes circulate in men and could increase in hypoxic conditions. It exerts a vasodilatory activity and can modulate the release of molecules, such as MMPs and VEGF. <b><i>Objectives:</i></b> The objective o…

AdultMaleVascular Endothelial Growth Factor APulmonary and Respiratory Medicinemedicine.medical_specialtyAmbulatory blood pressurePolysomnographyBlood PressurePolysomnographySettore MED/10 - Malattie Dell'Apparato Respiratorio030204 cardiovascular system & hematology03 medical and health sciences0302 clinical medicineRelaxin · Obstructive sleep apnea · Metalloproteinase · Vascular endothelial growth factorInterquartile rangeInternal medicineRespiratory disturbance indexmedicineHumansHypoxiaInflammationSleep Apnea ObstructiveTissue Inhibitor of Metalloproteinase-2Tissue Inhibitor of Metalloproteinase-1medicine.diagnostic_testbusiness.industryRelaxinSleep apneaTissue Inhibitor of MetalloproteinasesIntermittent hypoxiaMiddle Agedmedicine.diseaseMatrix MetalloproteinasesObstructive sleep apneaEndocrinologyBlood pressureMatrix Metalloproteinase 9030228 respiratory systemHypertensionMatrix Metalloproteinase 2Inflammation MediatorsbusinessRespiration
researchProduct

Effects of a nutraceutical formulation based on the combination of antioxidants and ω-3 essential fatty acids in the expression of inflamma…

2013

Maria D Pinazo-Durán,1,* Carmen Galbis-Estrada,1,* Sheila Pons-Vázquez,1 Jorge Cantú-Dibildox,2 Carla Marco-Ramírez,1 Javier Benítez-del-Castillo21Ophthalmic Research Unit Santiago Grisolia, Department of Surgery/Ophthalmology, Faculty of Medicine, University of Valencia, Valencia, Spain; 2Department of Ophthalmology, Hospital of Jerez, Jerez de la Frontera, Spain*These authors contributed equally to this workBackground: Women, and those older than 65 years of age, are particularly susceptible to dry eye disorders (DEDs). Inflammation is clearly involved in the pathogenesis of DEDs, and there is mounting evidence on the antioxidant and …

AdultMaleVascular Endothelial Growth Factor Amedicine.medical_specialtyessential polyunsaturated fatty acidsInterleukin-1betaInflammationnutraceuticsGastroenterologyAntioxidantsPathogenesischemistry.chemical_compoundRisk FactorsInternal medicineFatty Acids Omega-3HumansMedicineProspective StudiesInterleukin 6Prospective cohort studyAgedOriginal ResearchAged 80 and overchemistry.chemical_classificationbiologyInterleukin-6business.industryagingtearsInterleukinGeneral MedicineMiddle AgedcytokinesInterleukin-10Vascular endothelial growth factorchemistryClinical Interventions in AgingDietary SupplementsImmunologybiology.proteinTearsDry Eye SyndromesFemalewomenInflammation MediatorsGeriatrics and Gerontologymedicine.symptombusinessPolyunsaturated fatty acidClinical Interventions in Aging
researchProduct

Sensory profiles and immune-related expression patterns of patients with and without neuropathic pain after peripheral nerve lesion

2019

In this multicenter cross-sectional study, we determined sensory profiles of patients with (NL-1) and without neuropathic pain (NL-0) after nerve lesion and assessed immune-related systemic gene expression. Patients and matched healthy controls filled in questionnaires and underwent neurological examination, neurophysiological studies, quantitative sensory testing, and blood withdrawal. Neuropathic pain was present in 67/95 (71%) patients (NL-1). Tactile hyperalgesia was the most prominent clinical sign in NL-1 patients (P < 0.05). Questionnaires showed an association between neuropathic pain and the presence of depression, anxiety, and catastrophizing (P < 0.05 to P < 0.01). Neuropathic pa…

AdultMalemedicine.medical_specialtyAdolescentGene ExpressionNeurological examinationNerve fiberSensory systemGastroenterologyCohort StudiesYoung Adult03 medical and health sciencesNerve Fibers0302 clinical medicine030202 anesthesiologyInternal medicinemedicineHumansYoung adultDepression (differential diagnoses)AgedPain MeasurementAged 80 and overmedicine.diagnostic_testbusiness.industryCatastrophizationChronic painMiddle Agedmedicine.diseaseCross-Sectional StudiesAnesthesiology and Pain Medicinemedicine.anatomical_structureNeurologyNeuropathic painHyperalgesiaNeuralgiaFemaleNeurology (clinical)Inflammation Mediatorsmedicine.symptombusiness030217 neurology & neurosurgeryPain
researchProduct

Testosterone administration increases leukocyte-endothelium interactions and inflammation in transgender men

2021

Objective To evaluate the effect of testosterone treatment on metabolic and inflammation parameters and leukocyte-endothelium interactions in transgender men (TGM). Design Prospective observational study. Setting University hospital. Patient(s) One hundred fifty-seven TGM. Intervention(s) Administration of testosterone undecanoate (1,000 mg, intramuscular) every 12 weeks. Main Outcome Measure(s) Endocrine parameters, adhesion molecules (vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, and E-selectin), proinflammatory cytokines interleukin-6, and tumor necrosis factor alpha were evaluated in serum before and after treatment using Luminex’s xMAP technology. In additi…

AdultMalemedicine.medical_specialtyEndotheliumInjections Subcutaneousmedicine.medical_treatmentInflammationTransgender PersonsProinflammatory cytokineYoung AdultInternal medicineHuman Umbilical Vein Endothelial CellsLeukocytesHumansMedicineTestosteroneProspective StudiesCell adhesionCells CulturedTestosteroneInflammationbusiness.industryCell adhesion moleculeObstetrics and Gynecologymedicine.anatomical_structureCytokineEndocrinologyReproductive MedicineAndrogensTumor necrosis factor alphaEndothelium VascularInflammation Mediatorsmedicine.symptombusinessCell Adhesion MoleculesFertility and Sterility
researchProduct