Search results for "medical informatics"

Escala de percepción ante crisis y pandemias : desarrollo y validación de una escala pedagógica

2021

Objetivos: Abordar la metodología de estudio con respecto a epidemia/pandemia requiere involucrar pensamiento complejo frente a los retos que denota esta situación. El objetivo de este estudio es validar un cuestionario de percepción y creencias dirigido a estudiantes de medicina y enfermería sobre el uso del cine ante la complejidad de un evento pandémico, con el propósito de potenciar las estrategias de enseñanza. Metodología: Se encuestó a 131 estudiantes. La evaluación de la confiabilidad se realizó a través del análisis de consistencia interna. La valoración de los 19 ítems se evaluó mediante análisis de correlación de Pearson y la validez de constructo mediante análisis factorial expl…

What is science without replication?

2016

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Stakeholder Contradictions in Early Stages of eHealth Efforts

2017

Tendencia de la población española de búsqueda en internet sobre información relacionada con diferentes dietas

2020

Resumen Objetivo Explorar a traves Google Trends las tendencias del interes de la poblacion espanola sobre informacion relacionada con diferentes tipos de dietas, focalizadas en las mas populares y con estudios de evidencia, a lo largo de los ultimos 10 anos. Material y metodo Se analizaron las tendencias de busqueda de los terminos «dieta mediterranea», «dieta cetogenica», «dieta baja en grasas», «ayuno intermitente» y «dieta vegana». El volumen relativo de busqueda (VRB) de cada termino fue comparado. La direccion de la tendencia se estudio mediante la correlacion de Spearman (CS). Resultados El termino «dieta mediterranea» fue el mas buscado, con una mediana de VRB de 16 (rango intercuar…

Deep learning architectures for prediction of nucleosome positioning from sequences data

2018

Abstract Background Nucleosomes are DNA-histone complex, each wrapping about 150 pairs of double-stranded DNA. Their function is fundamental for one of the primary functions of Chromatin i.e. packing the DNA into the nucleus of the Eukaryote cells. Several biological studies have shown that the nucleosome positioning influences the regulation of cell type-specific gene activities. Moreover, computational studies have shown evidence of sequence specificity concerning the DNA fragment wrapped into nucleosomes, clearly underlined by the organization of particular DNA substrings. As the main consequence, the identification of nucleosomes on a genomic scale has been successfully performed by com…

A framework for data-driven adaptive GUI generation based on DICOM

2018

Computer applications for diagnostic medical imaging provide generally a wide range of tools to support physicians in their daily diagnosis activities. Unfortunately, some functionalities are specialized for specific diseases or imaging modalities, while other ones are useless for the images under investigation. Nevertheless, the corresponding Graphical User Interface (GUI) widgets are still present on the screen reducing the image visualization area. As a consequence, the physician may be affected by cognitive overload and visual stress causing a degradation of performances, mainly due to unuseful widgets. In clinical environments, a GUI must represent a sequence of steps for image investi…

Need for Deprescribing in Hospital Elderly Patients Discharged with a Limited Life Expectancy: The REPOSI Study

2019

<b><i>Objective:</i></b> Older people approaching the end of life are at a high risk for adverse drug reactions. Approaching the end of life should change the therapeutic aims, triggering a reduction in the number of drugs.<b><i></i></b>The main aim of this study is to describe the preventive and symptomatic drug treatments prescribed to patients discharged with a limited life expectancy from internal medicine and geriatric wards. The secondary aim was to describe the potentially severe drug-drug interactions (DDI). <b><i>Materials and Methods:</i></b> We analyzed Registry of Polytherapies Societa Italiana di Medicina I…

Data on the effects of low iron diet on serum lipid profile in HCV transgenic mouse model

2017

Here, we presented new original data on the effects of iron depletion on the circulating lipid profile in B6HCV mice, a murine model of HCV-related dyslipidemia. Male adult B6HCV mice were subjected to non-invasive iron depletion by low iron diet. Serum iron concentration was assessed for evaluating the effects of the dietary iron depletion. Concentrations of circulating triglycerides, total cholesterol, Low Density Lipoproteins (LDLs), High Density Lipoproteins (HDLs) were analyzed and reported by using stacked line charts. The present data indicated that low serum iron concentration is associated to i) lower serum triglycerides concentrations and ii) increased circulating LDLs. The presen…

CLOVE: classification of genomic fusions into structural variation events

2017

Background A precise understanding of structural variants (SVs) in DNA is important in the study of cancer and population diversity. Many methods have been designed to identify SVs from DNA sequencing data. However, the problem remains challenging because existing approaches suffer from low sensitivity, precision, and positional accuracy. Furthermore, many existing tools only identify breakpoints, and so not collect related breakpoints and classify them as a particular type of SV. Due to the rapidly increasing usage of high throughput sequencing technologies in this area, there is an urgent need for algorithms that can accurately classify complex genomic rearrangements (involving more than …

Quantitative super-resolution localization microscopy of DNA in situ using Vybrant® DyeCycle™ Violet fluorescent probe.

2016

Single Molecule Localization Microscopy (SMLM) is a recently emerged optical imaging method that was shown to achieve a resolution in the order of tens of nanometers in intact cells. Novel high resolution imaging methods might be crucial for understanding of how the chromatin, a complex of DNA and proteins, is arranged in the eukaryotic cell nucleus. Such an approach utilizing switching of a fluorescent, DNA-binding dye Vybrant® DyeCycle™ Violet has been previously demonstrated by us (Żurek-Biesiada et al., 2015) [1]. Here we provide quantitative information on the influence of the chemical environment on the behavior of the dye, discuss the variability in the DNA-associated signal density,…