Search results for "medical sciences"
showing 10 items of 208 documents
Emotion regulation in adolescents with anorexia and bulimia nervosa: Differential use of adaptive and maladaptive strategies compared to healthy adol…
2021
Objective: Adolescents with anorexia (AN) and bulimia nervosa (BN) often struggle with emotion regulation (ER). These difficulties have predominantly been assessed across emotions, without considering adaptive and maladaptive ER separately.We compared adolescents with AN or BN to healthy adolescents (HCs) regarding the adaptive and maladaptive ER of three emotions. Methods: A treatment-seeking sample of 197 adolescents (atypical/full-threshold AN: N = 118, atypical/full-threshold BN: N = 32; HC: N = 47) reported emotion-specific ER with the FEEL-KJ questionnaire. Mixed models were calculated for adaptive and maladaptive ER to assess differences between emotions (anxiety, anger, sadness) and…
Impact of Legislative Changes on the Availability of Medicines and Pharmacovigilance Activities
2021
Zāļu pieejamība ir vispārējas cilvēktiesības, tomēr tā joprojām saglabājas globāla problēma. Šajā pētījumā par objektu izvēlēts Latvijas lielākās kaimiņvalsts – Krievijas Federācijas (KF) – zāļu normatīvais regulējums, kurā 2010. gadā notika radikālas izmaiņas, kas noveda pie papildu administratīvā sloga un ietekmes uz zāļu pieejamību un farmakovigilances aktivitātēm. Tā kā Latvijas farmaceitiskajiem uzņēmumiem un citu Eiropas Savienības (ES) valstu zāļu ražotājiem KF tirgus ir nozīmīgs, tiem būtu noderīgi iegūt zinātnisku ieskatu zāļu reģistrāciju regulējošos procesos kas palīdzētu uzlabot to darbību. Pētījums ir nozīmīgs arī valsts iestāžu darbiniekiem, lai paredzētu sekas un plānotu norm…
A trifunctional dextran-based nanovaccine targets and activates murine dendritic cells, and induces potent cellular and humoral immune responses in v…
2013
Dendritic cells (DCs) constitute an attractive target for specific delivery of nanovaccines for immunotherapeutic applications. Here we tested nano-sized dextran (DEX) particles to serve as a DC-addressing nanocarrier platform. Non-functionalized DEX particles had no immunomodulatory effect on bone marrow (BM)-derived murine DCs in vitro. However, when adsorbed with ovalbumine (OVA), DEX particles were efficiently engulfed by BM-DCs in a mannose receptor-dependent manner. A DEX-based nanovaccine containing OVA and lipopolysaccharide (LPS) as a DC stimulus induced strong OVA peptide-specific CD4(+) and CD8(+) T cell proliferation both in vitro and upon systemic application in mice, as well a…
Implantation of silicon dioxide-based nanocrystalline hydroxyapatite and pure phase beta-tricalciumphosphate bone substitute granules in caprine musc…
2012
Abstract Background Osteoinductive bone substitutes are defined by their ability to induce new bone formation even at heterotopic implantation sites. The present study was designed to analyze the potential osteoinductivity of two different bone substitute materials in caprine muscle tissue. Materials and methods One gram each of either a porous beta-tricalcium phosphate (β-TCP) or an hydroxyapatite/silicon dioxide (HA/SiO2)-based nanocrystalline bone substitute material was implanted in several muscle pouches of goats. The biomaterials were explanted at 29, 91 and 181 days after implantation. Conventional histology and special histochemical stains were performed to detect osteoblast precurs…
Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells.
2011
Breast cancer is the most common cancer and the second leading cause of cancer death in industrialized countries. Systemic treatment of breast cancer is effective at the beginning of therapy. However, after a variable period of time, progression occurs due to therapy resistance. Artesunate, clinically used as anti-malarial agent, has recently revealed remarkable anti-tumor activity offering a role as novel candidate for cancer chemotherapy. We analyzed the anti-tumor effects of artesunate in metastasizing breast carcinoma in vitro and in vivo. Unlike as expected, artesunate induced resistance in highly metastatic human breast cancer cells MDA-MB-231. Likewise acquired resistance led to abol…
Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers
2014
Introduction More than 70 common alleles are known to be involved in breast cancer (BC) susceptibility, and several exhibit significant heterogeneity in their associations with different BC subtypes. Although there are differences in the association patterns between BRCA1 and BRCA2 mutation carriers and the general population for several loci, no study has comprehensively evaluated the associations of all known BC susceptibility alleles with risk of BC subtypes in BRCA1 and BRCA2 carriers. Methods We used data from 15,252 BRCA1 and 8,211 BRCA2 carriers to analyze the associations between approximately 200,000 genetic variants on the iCOGS array and risk of BC subtypes defined by estrogen re…
Oligodendroglial p130Cas Is a Target of Fyn Kinase Involved in Process Formation, Cell Migration and Survival
2014
Oligodendrocytes are the myelinating glial cells of the central nervous system. In the course of brain development, oligodendrocyte precursor cells migrate, scan the environment and differentiate into mature oligodendrocytes with multiple cellular processes which recognize and ensheath neuronal axons. During differentiation, oligodendrocytes undergo dramatic morphological changes requiring cytoskeletal rearrangements which need to be tightly regulated. The non-receptor tyrosine kinase Fyn plays a central role in oligodendrocyte differentiation and myelination. In order to improve our understanding of the role of oligodendroglial Fyn kinase, we have identified Fyn targets in these cells. Pur…
Physical activity specifically evokes release of cell-free DNA from granulocytes thereby affecting liquid biopsy
2022
Clinical epigenetics 14, 29 (2022). doi:10.1186/s13148-022-01245-3
ATRIP protects progenitor cells against DNA damage in vivo
2020
AbstractThe maintenance of genomic stability during the cell cycle of progenitor cells is essential for the faithful transmission of genetic information. Mutations in genes that ensure genome stability lead to human developmental syndromes. Mutations in Ataxia Telangiectasia and Rad3-related (ATR) or in ATR-interacting protein (ATRIP) lead to Seckel syndrome, which is characterized by developmental malformations and short life expectancy. While the roles of ATR in replicative stress response and chromosomal segregation are well established, it is unknown how ATRIP contributes to maintaining genomic stability in progenitor cells in vivo. Here, we generated the first mouse model to investigat…
Características y visibilidad de las revistas españolas de ciencias de la salud en bases de datos
2015
Se describen las características de 207 revistas españolas de ciencias de la salud activas en 2014 y su visibilidad en seis bases de datos biomédicas y multidisciplinares. Scopus e Ibecs son las bases de datos que mayor número de revistas cubren, y Medline y WoS las que menos. La disciplina mejor representada es medicina, seguida de psicología, enfermería y farmacia. Se observa la práctica ausencia de revistas editadas exclusivamente en papel, la existencia de revistas publicadas en inglés, el aumento de versiones bilingües español-inglés y el acceso gratuito a los contenidos. El artículo incorpora el censo de revistas, que puede servir de referencia para los investigadores para selecciona…