Search results for "methodology."
showing 10 items of 822 documents
FASTA/Q data compressors for MapReduce-Hadoop genomics: space and time savings made easy
2021
Abstract Background Storage of genomic data is a major cost for the Life Sciences, effectively addressed via specialized data compression methods. For the same reasons of abundance in data production, the use of Big Data technologies is seen as the future for genomic data storage and processing, with MapReduce-Hadoop as leaders. Somewhat surprisingly, none of the specialized FASTA/Q compressors is available within Hadoop. Indeed, their deployment there is not exactly immediate. Such a State of the Art is problematic. Results We provide major advances in two different directions. Methodologically, we propose two general methods, with the corresponding software, that make very easy to deploy …
Metaphysics of cosmological models
2023
This article aims to address the metaphysical dimension of cosmological models, be they mythological, philosophical, religious or modern scientific models, using multidisciplinary and transdisciplinary methodology. Such an approach is a novelty, both in the theological field and in the philosophical field and secular sciences, which studies the origin of humans and the universe. Contribution: The originality of this article consists in introducing the concept of transcendental cosmology, which, along with spiritual cosmology, can be a serious theological and philosophical reply to the Bing Bang theory.
A motif-independent metric for DNA sequence specificity
2011
Abstract Background Genome-wide mapping of protein-DNA interactions has been widely used to investigate biological functions of the genome. An important question is to what extent such interactions are regulated at the DNA sequence level. However, current investigation is hampered by the lack of computational methods for systematic evaluating sequence specificity. Results We present a simple, unbiased quantitative measure for DNA sequence specificity called the Motif Independent Measure (MIM). By analyzing both simulated and real experimental data, we found that the MIM measure can be used to detect sequence specificity independent of presence of transcription factor (TF) binding motifs. We…
Six Sigma in small- and medium-sized enterprises: a Black Belt project in the Swedish steel industry
2014
Many big companies around the world have solid Six Sigma infrastructures and it is easy to find in literature successful case studies. Conversely, small and medium-sized enterprises (SMEs) generally suffer lower attention in the literature. This happens because SMEs have only recently approached the methodology; they have weaker connection with the academia; or they do not rigorously pursue the frameworks. This paper is based on a Six Sigma project in a Swedish medium-sized company that produces steel tubes mainly for hydraulic applications. The project focused on the improvement of warehouse activities related to cutting processes. This Black Belt project was part of a Six Sigma education …
Development and validation of the neighborhood environment walkability scale for youth across six continents
2019
Abstract Background The IPEN International Physical Activity and Environment Network Adolescent project was conducted using common study protocols to document the strength, shape, and generalizability of associations of perceived neighborhood environment attributes with adolescents’ physical activity and overweight/obesity using data from 15 countries. Countries did not use identical versions of the Neighborhood Environment Walkability Scale for Youth (NEWS-Y) to measure perceived neighborhood environment attributes. Therefore, this study derived a measurement model for NEWS-Y items common to all IPEN Adolescent countries and developed a scoring protocol for the IPEN Adolescent version of t…
Design methodology for submerged anaerobic membrane bioreactors (AnMBR): A case study
2015
[EN] The main objective of this study is to propose guidelines for designing submerged anaerobic MBR (AnMBR) technology for municipal wastewater treatment. The design methodology was devised on the basis of simulation and experimental results from an AnMBR plant featuring industrial-scale hollow-fibre membranes. The proposed methodology aims to minimise both capital expenditure and operating expenses, and the key parameters considered were: hydraulic retention time, solids retention time, mixed liquor suspended solids concentration in the membrane tank, 20 C-standardised critical flux, specificgas demand per square metre of membrane area, and flow of sludge being recycled from the membrane …
Analysis of Profiles of Family Educational Situations during COVID-19 Lockdown in the Valencian Community (Spain)
2022
Due to the pandemic (COVID-19), the education system in Spain was forced to close for three months, creating an unprecedented situation: improvised distance schooling. Family characteristics and their life situations with Information and Communication Technology use would be aspects to be studied as educational conditioning factors. This paper presents the ways in which a representative sample of families in the Valencian Community (Spain) assumed the education of their children during the lockdown. Mixed methods (quantitative -surveys-/qualitative -focus groups-) are used. Multivariate profiles are studied (k-means cluster) that summarise the life circumstances, represented by composite in…
Towards a multi-agent model to prevent damage caused by cocoa mirids to cocoa pods
2019
Agriculture in general and cocoa farm in particular is one of the primary sources of income for several African countries. Although quite useful for the development of Africa, cocoa production is faced with several challenges like the diseases of cocoa trees. Mirid (Sahlbergella singularis) is the worst pest affecting cocoa production across west Africa causing 30% to 40% of damage on cocoa production. It is difficult to control the mirids’ population and its impact on the cacao production. Related works on mirids studied the mirids population as a macroscopic entity without considering local interactions of individual mirids. These models did not consider the behaviours and the environment…
Una propuesta sobre enseñanza de la relatividad en el bachillerato como motivación para el aprendizaje de la física
2007
Relativity is a very important part of modern physics. In this paper we analyze the teaching and learning of the theory of relativity in secondary education and we show some reasoned arguments against traditional methods to teach it. Finally, a didactic proposal for the teaching of relativity is presented; it comes as a conclusion that it is possible a suitable teaching of the principles of relative which should bring into the students a change in attitude, concepts and methodology.
Assessment of Postharvest Dehydration Kinetics and Skin Mechanical Properties of “Muscat of Alexandria” Grapes by Response Surface Methodology
2016
The dipping of berries in a dilute solution of sodium hydroxide during a short time was evaluated as pretreatment undertaken prior to convective dehydration of wine grapes. The impact of the sodium hydroxide content and dipping time on weight loss (WL) at different dehydration times was thoroughly assessed using central composite design (CCD) and response surface methodology (RSM). Furthermore, the effects of these two variables were also investigated on the skin mechanical properties of dehydrated grapes. The effect of these two pretreatment factors on the dehydration kinetics and skin hardness was satisfactorily fitted to regression models. The berry pretreatment with low sodium hydroxide…