Search results for "methods"

Volumetric Enhancing Tumor Burden at CT to Predict Survival Outcomes in Patients with Neuroendocrine Liver Metastases after Intra-arterial Treatment

2023

Purpose To investigate whether liver enhancing tumor burden (LETB) assessed at contrast-enhanced CT indicates early response and helps predict survival outcomes in patients with multifocal neuroendocrine liver metastases (NELM) after intra-arterial treatment. Materials and Methods This retrospective study included patients with NELM who underwent intra-arterial treatment with transarterial embolization (TAE) or chemoembolization (TACE) between April 2006 and December 2018. Tumor response in treated NELM was evaluated by using the Response Evaluation Criteria in Solid Tumors (RECIST) and modified RECIST (mRECIST). LETB was measured as attenuation 2 SDs greater than that of a region of intere…

Detection methods predict differences in biology and survival in breast cancer patients

2012

Abstract Background The aim of this study was to measure the biological characteristics involved in tumorigenesis and the progression of breast cancer in symptomatic and screen-detected carcinomas to identify possible differences. Methods For this purpose, we evaluated clinical-pathological parameters and proliferative and apoptotic activities in a series of 130 symptomatic and 161 screen-detected tumors. Results After adjustment for the smaller size of the screen-detected carcinomas compared with symptomatic cancers, those detected in the screening program presented longer disease-free survival (RR = 0.43, CI = 0.19-0.96) and had high estrogen and progesterone receptor concentrations more …

Human Thyroid Cancer Stem Cells

2011

Increasing advances in stem cell research have opened new chances for treatment of many types of cancers. The identification of Cancer Stem Cells (CSCs) will provide a better knowledge of the molecular events governing carcinogenesis and the establishment of more accurate diagnostic methods and effective therapies. Parallel to other tumors, it has been demonstrated the presence of CSCs in thyroid cancers. Here, we will discuss the origin of human thyroid cancer stem cells and what is known about the molecular and the cellular aspects of their biology. We will also explore the potential traits of CSCs in thyroid cancer which give hope for the development of new therapeutic approaches in trea…

European Society for Medical Oncology (ESMO) position paper on supportive and palliative care

2018

Oncology has come a long way in addressing patients' quality of life, together with developing surgical, radio-oncological and medical anticancer therapies. However, the multiple and varying needs of patients are still not beingmet adequately as part of routine cancer care. Supportive and palliative care interventions should be integrated, dynamic, personalised and based on best evidence. They should start at the time of diagnosis and continue through to end-of-life or survivorship. ESMO is committed to excellence in all aspects of oncological care during the continuum of the cancer experience. Following the 2003 ESMO stand on supportive and palliative care (Cherny N, Catane R, Kosmidis P. …

13P Comparison study of different programmed death-ligand 1 (PD-L1) assays, readers and scoring methods in triple-negative breast cancer (TNBC)

2021

Spreading dynamics of three-dimensional droplets by the lattice-Boltzmann method

2000

Abstract We have simulated spreading of small droplets on smooth and rough solid surfaces using the three-dimensional lattice-Boltzmann method. We present results for the influence of the initial distance and shape of the drop from the surface on scaling of droplet radius R as a function of time. For relatively flat initial drop shapes our observations are consistent with Tanner's law R ∼ t q , where q =1/10. For increasingly spherical initial shapes, the exponent q increases rapidly being above one half for spherical droplets initially just above the surface. As expected, surface roughness slows down spreading, decreases the final drop radius, and results in irregular droplet shape due to …

Non-LTE radiation hydrodynamics in PLUTO

2019

Modeling the dynamics of most astrophysical structures requires an adequate description of the radiation-matter interaction. Several numerical (magneto)hydrodynamics codes were upgraded with a radiation module to fulfill this request. However, those among them that use either the flux-limited diffusion (FLD) or the M1 radiation moment approaches are restricted to the local thermodynamic equilibrium (LTE). This assumption may be not valid in some astrophysical cases. We present an upgraded version of the LTE radiation-hydrodynamics module implemented in the PLUTO code, originally developed by Kolb et al. (2013), which we have extended to handle non-LTE regimes. Starting from the general freq…

Online Hate Speech in the European Union : A Discourse-Analytic Perspective

2017

This book is open access under a CC BY 4.0 license and reports on research carried out as part of the European Union co-funded C.O.N.T.A.C.T. project which targeted hate speech and hate crime across a number of EU member states. It showcases the bearing that discourse analytic research can have on our understanding of this phenomenon that is a growing global cause for concern. Although ‘hate speech’ is often incorporated in legal and policy documents, there is no universally accepted definition, which in itself warrants research into how hatred is both expressed and perceived. The research project synthesises discourse analytic and corpus linguistics techniques, and presents its key finding…

Introduction : Open Dialogue around the world – implementation, outcomes, experiences and perspectives

2023

Datos abiertos de investigación. Camino recorrido y cuestiones pendientes

2017

[ES]: Los aspectos profesionales y técnicos de la gestión de datos de investigación han avanzado, por ejemplo las infraestructuras tecnológicas o los esquemas de metadatos de descripción. Sin embargo, otras cuestiones siguen necesitando ser investigadas, y más ahora en que los datos han de estar disponibles en abierto. Este trabajo efectúa una revisión bibliográfica y de sitios web de referencia que permite identificar los últimos avances producidos y las tendencias de investigación en temas relacionados con los datos científicos. La publicación de datos en revistas, el estudio del comportamiento de los autores o los métodos para medir el impacto de los datos son aspectos que necesitan ser …