Search results for "miR"
showing 10 items of 1117 documents
Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFbeta signaling pathway in SW480 cells.
2010
International audience; Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural antioxidant with cardiovascular and cancer preventive properties that is currently at the stage of pre-clinical studies for human cancer prevention. Beside its known effects on protein coding genes, one possible mechanism for resveratrol protective activities is by modulating the levels of non-coding RNAs. Here, we analyzed the effects of resveratrol on microRNA populations in human SW480 colon cancer cells. We establish that resveratrol treatment decreases the levels of several oncogenic microRNAs targeting genes encoding Dicer1, a cytoplasmic RNase III producing mature microRNAs from their immediate precurs…
Der Philosoph W. Solowioff und das Judentum [Philosoph W. Solowjow und das Judentum]
1927
Inhaltsverzeichnis: Vorwort 5 l. W. Solowioffs und das Judentum ll. W. Solowioffs Protest gegen den Antisemitismus 17 111. Das religiöse Gewissen erweckt in W. S. lnteresse für das Judentum 22 IV. W. Solowioffs Interesse für Juden 29 V. Die Bekanntschaft mit Juden macht W. S. zu ihrem Apologeten 32 VI. Juden zuverteidigen war für W. S. religiöse und patriotische Pflicht 35 Vll. W. Solowioffs jüdische Apologie 39 Vlll. W. S. über das Verhältnis des Christentums zum Judentum 46 IX. W. S. über die Beziehungen der Evangelien zum Talmud 57 X. W. Solowioffs originelle Polemik. 65 Xl. Widerlegung der nationalen Beschuldigungen 74 Xll. Widerlegung der ökonomischen Beschuldigung 77 Xlll. Wideflegung…
To the research of treatments for the typical calcific disease of old aortic valve in the omics era: Is the miR-195 a therapeutic signature via targe…
2020
Calcific aortic valve disease (CAVD) is the most frequent form of val-vular pathology [1,2], with high percentages of mortality and morbidityin Western populations, so much to be a very public health problem [2].Diverse millions of subjects are affected by CAVD and the major numberare old individuals (65- older), even if some have a younger age and aregenerally affected by congenital bicuspid aortic valve (BAV) disease[2,3]. CAVD in BAV individuals arises decades earlier respect to subjectswith the physiological tricuspid aortic valve [3]. Furthermore, it can leadto death if untreated with surgical aortic valve replacement or trans-catheter aortic valve implantation, its unique treatments […
Comparison of discretization strategies for the model-free information-theoretic assessment of short-term physiological interactions
2023
This work presents a comparison between different approaches for the model-free estimation of information-theoretic measures of the dynamic coupling between short realizations of random processes. The measures considered are the mutual information rate (MIR) between two random processes [Formula: see text] and [Formula: see text] and the terms of its decomposition evidencing either the individual entropy rates of [Formula: see text] and [Formula: see text] and their joint entropy rate, or the transfer entropies from [Formula: see text] to [Formula: see text] and from [Formula: see text] to [Formula: see text] and the instantaneous information shared by [Formula: see text] and [Formula: see…
The role of post-transcriptional modulators of metalloproteins in response to metal deficiencies
2021
Copper and iron proteins play a wide range of functions in living organisms. Metal assembly into metalloproteins is a complex process, where mismetalation is detrimental and energy-consuming to cells. Under metal deficiency, metal distribution is expected to reach a metalation ranking, prioritizing essential versus dispensable metalloproteins, while avoiding interferences with other metals and protecting metal-sensitive processes. In this review, we propose that posttranscriptional Modulators of Metalloprotein messenger RNA (ModMeR) are good candidates in metal prioritization under metal-limited conditions. ModMeR target high quota or redundant metalloproteins and, by adjusting their synthe…
Ajatuksia koulutusviennistä – mahdollisuudet ja riskit vaakakupissa
2015
Koulutusosaamisen viennistä tulee kehittää yksi Suomen tulevaisuuden tärkeimmistä vientituotteista. Näin kaavailtiin vuonna 2010 julkaistussa opetus- ja kulttuuriministeriön raportissa (OKM 2010). Suomessa ajatus koulutuksesta vientituotteena on suhteellisen tuore käsite ja kattaa laajan skaalan erilaisia koulutusosaamisen viennin muotoja. Monissa muissa maissa, etenkin Australiassa, Isossa-Britanniassa sekä Yhdysvalloissa, koulutuksella on tehty kauppaa yli rajojen jo vuosikymmeniä. Koulutuksen suurimmat vientimaat ovat luonnollisesti englanninkielisiä maita, joiden koulutusosaamisella on kysyntää yli rajojen, ja joissa tutkintomaksut ovat arkipäivää. Usein näissä maissa väestörakenteen mu…
Last Millennium hydro-climate variability in Central–Eastern Europe (Northern Carpathians, Romania)
2015
Proxy-based reconstructions of climate variability over the last millennium provide important insights for understanding current climate change within a long-term context. Past hydrological changes are particularly difficult to reconstruct, yet rainfall patterns and variability are among the most critical environmental variables. Ombrotrophic bogs, entirely dependent on water from precipitation and sensitive to changes in the balance between precipitation and evapotranspiration, are highly suitable for such hydro-climate reconstructions. We present a multi-proxy analysis (testate amoebae, plant macrofossils, stable carbon isotopes in Sphagnum, pollen, spores and macroscopic charcoal) from …
Aspetti configurativi organizzativi dell'Arsenale
2017
L’edificazione dell’Arsenale, sebbene fosse localizzata nella parte estrema della banchina che portava al grande Molo, non rimase isolata. Quasi adia- cente all’Arsenale esisteva, già dal 1569, la Chiesa di Santa Maria del Popolo, detta “della Vittoria”, cui si aggiunse, a partire dal 1625, il convento dei Padri Mercedari Scalzi. Dalla parte opposta, sempre in adiacenza all’Arsenale, la Regia Corte aveva realizzato degli ampi magazzini e, in successione a que- st’ultimi edifici, era sorto un vasto palazzo suburbano, dotato di un ampio giardino, appartenuto nel Settecento ai principi Tomasi di Lampedusa e in seguito ai De Gregorio, marchesi del Parco Reale Anche nella parte retrostante, dove…
Ultradeep Sequencing Analysis of Population Dynamics of Virus Escape Mutants in RNAi-Mediated Resistant Plants
2012
Plant artificial micro-RNAs (amiRs) have been engineered to target viral genomes and induce their degradation. However, the exceptional evolutionary plasticity of RNA viruses threatens the durability of the resistance conferred by these amiRs. It has recently been shown that viral populations not experiencing strong selective pressure from an antiviral amiR may already contain enough genetic variability in the target sequence to escape plant resistance in an almost deterministic manner. Furthermore, it has also been shown that viral populations exposed to subinhibitory concentrations of the antiviral amiR speed up this process. In this article, we have characterized the molecular evolutiona…
Desert dust aerosol air mass mapping in the western Sahara, using particle properties derived from space-based multi-angle imaging
2009
Coincident observations made over the Moroccan desert during the Sahara mineral dust experiment (SAMUM) 2006 field campaign are used both to validate aerosol amount and type retrieved from multi-angle imaging spectroradiometer (MISR) observations, and to place the suborbital aerosol measurements into the satellite's larger regional context. On three moderately dusty days during which coincident observations were made, MISR mid-visible aerosol optical thickness (AOT) agrees with field measurements point-by-point to within 0.05–0.1. This is about as well as can be expected given spatial sampling differences; the space-based observations capture AOT trends and variability over an extended regi…