Search results for "miR"

Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome.

2015

During embryo implantation, the blastocyst interacts with and regulates the endometrium, and endometrial fluid secreted by the endometrial epithelium nurtures the embryo. Here, we propose that maternal microRNAs (miRNAs) might act as transcriptomic modifier of the pre-implantation embryo. Microarray profiling revealed that six of 27 specific, maternal miRNAs were differentially expressed in the human endometrial epithelium during the window of implantation – a brief phase of endometrial receptivity to the blastocyst – and were released into the endometrial fluid. Further investigation revealed that hsa-miR-30d, the expression levels of which were most significantly upregulated, was secreted…

Non-coding RNAs and Coronary Artery Disease

2020

Coronary artery disease (CAD) is the leading death cause worldwide. Non-coding RNA (ncRNA) are key regulators of genetic expression and thus can affect directly or indirectly the development and progression of different diseases. ncRNA can be classified in several types depending on the length or structure, as long non-coding RNA (lncRNA), microRNA (miRNA) and circularRNA (circRNA), among others. These types of RNA are present within cells or in circulation, and for this reason they have been used as biomarkers of different diseases, therefore revolutionizing precision medicine. Recent research studied the capability of circulating ncRNA to inform about CAD presence and predict the outcome …

Rear-view mirror use, driver alertness and road type: An empirical study using EEG measures

2006

Abstract The use of rear-view mirrors has been suggested as a good behavioural indicator of driver alertness in traffic situations (Brookhuis, K. A., De Vries, G., & De Waard, D. (1991). The effects of mobile telephoning on driving performance. Accident Analysis and Prevention, 23 (4), 309–316). In general terms, drivers look in the mirrors to find information and adapt their driving to traffic variations. This paper aims to analyse the links between time variations in alertness—measured from EEG activity data—and the frequency of rear-view mirror use in a group of drivers, both on motorways and conventional roads. The results point to a direct relationship between alertness level and mirro…

Sub-mA current measurement by means of GMR sensors and state of the art lock-in amplifiers

2015

Electric current measurement at the range of μA in integrated circuit has been traditionally carried out by micro-electronically engineered systems, such as current mirrors or charging capacitors. However, off-line, i.e., non-intrusive methods provide advantages related to size and power consumption. In this sense, giant magnetoresistance (GMR) magnetic sensors are optimal due to their sensitivity and CMOS compatibility. In this work, we make use of specifically designed CMOS GMR-based current sensors in combination with a custom electronic interface based on a low-voltage low-power lock-in amplifier, demonstrating the capability of this combination for current measurement in the range of μ…

NEL SEGNO DELL’ÀNCORA La contea di Modica nel dominio degli Enriquéz almiranti di Castiglia

2012

Il saggio muove dall’analisi dei processi sociali, culturali, politici che segnarono l’avvio della stagione moderna nella contea di Modica. Recuperando la centralità degli attori del dominio, gli Enriquéz, ben oltre la sequenza cronologica dei fatti e dei passaggi ereditari, il testo delinea i contorni di un progetto dinastico che, nel suo divenire, contemplava la proiezione dei feudi nella rete mediterranea ed europea della monarchia spagnola. Non due storie parallele, quella della contea e quella dei conti, distratti e lontani, ma un’unica storia che, sullo sfondo di un’analisi di longue durée, sposta in avanti l’asse cronologico fissato dagli Atti del settimo centenario della contea cura…

Corrigendum to: Revision of the New World species of Peritropis Uhler (Hemiptera: Miridae: Cylapinae) (Insect Systematics & Evolution 43 (2012): …

2013

Revision of the New World Species of Peritropis Uhler (Heteroptera: Miridae: Cylapinae)

2012

The New World species of the genus Peritropis are revised, and 17 new species are described: P. amazonica, P. amphicyrta, P. carpinteroi, P. carvalhoi, P. conspersa, P. cornata, P. gorczycai, P. guarani, P. izyai, P. marmorea, P. nicaraguensis. P. plaumanni, P. schaffneri, P. scutellata, P. stobieckii, P. turrialba and P. venezuelaensis. All previously known species from the New World (P. husseyi Knight, P. saldaeformis Uhler, and P. tuberculata McAtee and Malloch) are redescribed, except P. unicolor Carvalho and Rosas for which an English translation of the original description is provided. Illustrations of the male genitalia, a color photograph of the adult of each species, scanning elect…

Epigenetic biomarkers: A new perspective in laboratory diagnostics.

2012

Epigenetics comprises the study of chemical modifications in the DNA and histones that regulates the gene expression or cellular phenotype. However, during the last decade this term has evolved after the elucidation of different mechanisms (microRNAs and nuclear organization of the chromosomes) involved in regulating gene expression. Epigenetics and the new designed technologies capable to analyze epigenetic changes (e.g., methylated DNA, miRNAs expression, post-translational modifications on histones among others) have disclosed an appealing scenario that will offer for the biomedical sciences new biomarkers for the study of neurodegenerative diseases, multifactorial complex diseases, rare…

Key nodes of a microRNA network associated with the integrated mesenchymal subtype of high-grade serous ovarian cancer

2015

Metastasis is the main cause of cancer mortality. One of the initiating events of cancer metastasis of epithelial tumors is epithelial-to-mesenchymal transition (EMT), during which cells dedifferentiate from a relatively rigid cell structure/morphology to a flexible and changeable structure/morphology often associated with mesenchymal cells. The presence of EMT in human epithelial tumors is reflected by the increased expression of genes and levels of proteins that are preferentially present in mesenchymal cells. The combined presence of these genes forms the basis of mesenchymal gene signatures, which are the foundation for classifying a mesenchymal subtype of tumors. Indeed, tumor classifi…

El examinador confirmado en su mismo examen : de ser fabulosa i de burla, la permanencia del Oratorio de ls Virtudes en tiempo de moros i su sitio, s…

1746

Vinyeta a port Caplletra ornada, filets Sign.: A8 Tex a 1 col. - Reclams