Search results for "middle"
showing 10 items of 15335 documents
Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis
2006
The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-beta1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-beta1 and IL-10 polymorphisms in atherosclerosis.
Is COVID‐19 infection more severe in kidney transplant recipients?
2021
International audience; There are no studies which have compared the risk of severe Covid-19 and related mortality between transplant recipients and non-transplant patients. We enrolled two groups of patients hospitalized for Covid-19, i.e., kidney transplant recipients from the French Registry of Solid Organ Transplant (n=306) and a single-center cohort of non-transplant patients (n=795). An analysis was performed among subgroups matched for age and risk factors for severe Covid-19 or mortality. Severe Covid-19 was defined as admission (or transfer) to an intensive care unit, need for mechanical ventilation, or death.Transplant recipients were younger and had more comorbidities compared to…
Taisteluiden kuvaus Eerikinkronikassa : sukupuolihistoriallinen näkökulma hyvään soturiuteen keskiajalla
2018
Kandidaatintutkielma taisteluista Eerikinkronikassa, johon sisältyy siinä esiintyvän soturiuden tutkiminen sukupuolihistorian näkökulmassa (maskuliinisuuden tutkimus).
CD40 activity on mesenchymal cells negatively regulates OX40L to maintain bone marrow immune homeostasis under stress conditions
2021
BackgroundWithin the bone marrow (BM), mature T cells are maintained under homeostatic conditions to facilitate proper hematopoietic development. This homeostasis depends upon a peculiar elevated frequency of regulatory T cells (Tregs) and immune regulatory activities from BM-mesenchymal stem cells (BM-MSCs). In response to BM transplantation (BMT), the conditioning regimen exposes the BM to a dramatic induction of inflammatory cytokines and causes an unbalanced T-effector (Teff) and Treg ratio. This imbalance negatively impacts hematopoiesis, particularly in regard to B-cell lymphopoiesis that requires an intact cross-talk between BM-MSCs and Tregs. The mechanisms underlying the ability of…
Recensione di “Storie di donne nel Medioevo” di Maria Teresa Brolis
2017
Review of M.T. Brolis, Storie di donne nel medioevo
Updating the Philosophy of Middle-Range Theories : Implications for IS
2018
Merton’s concepts of middle-range theories (MRTs) and grand theories (GTs) are widely mentioned in information systems (IS) theorizing literature. On one hand, numerous IS authors claim that MRTs are common in IS or that design science theories are MRTs. On the other hand, others report that too much focus is placed on GTs (instead of MRTs) in IS. Moreover, MRTs and GTs have acquired a normative role in IS. Given such disagreements and the normative role of MRTs and GTs, there is a need to examine what Merton’s GT and MRT are. The aim of this paper is to start such a discussion by providing an interpretation of Merton’s GT and MRT. We contest many IS views on Merton. We also suggest that Me…
Walking Stroop carpet: an innovative dual-task concept for detecting cognitive impairment
2013
A Perrochon,1,2,5 G Kemoun,1,2 E Watelain,3,4 A Berthoz51ISIS, Research Institute on Handicap and Aging, Paris; 2Université de Poitiers, Laboratoire Mobilité, Vieillissement et Exercice (MOVE), EA 6314, 3Université de Valenciennes, LAMIH, UMR CNRS 8201, 4Université Sud Toulon Var, HandiBio, EA 4322, La Garde, 5LPPA, UMR CNRS 7152, Collège de France, Paris, FranceBackground: Several studies have reported the potential value of the dual-task concept during locomotion in clinical evaluation because cognitive decline is strongly associated with gait abnormalities. However, current dual-task tests appear to be insufficient for early diagnosi…
Continuous subcutaneous Insulin infusion leads to immediate, table, and long-term changes in metabolic control
2008
Background: Evaluations of continuous subcutaneous insulin infusion (CSII) usually focus on one pre- and one post-CSII measurement to assess metabolic therapy outcome. Aim: Extending this research, the aim of the present study was to provide a more fine-grained analysis of achieved glycaemic control. Methods: In 52 patients with type 1 diabetes (mean age of 37.85 years at CSII begin; s.d. ± 12.41), haemoglobin A1c (HbA1c) levels were assessed every 3 months over a period of 5 years (1 year before and 4 years after the introduction of CSII). Mixed models were utilized to describe changes in glycaemic control. Results: The pre–post course showed that already in the first quarter, a statis…
Monastères et espace urbain au haut Moyen Âge
2012
In both episcopal cities studied here, Auxerre and Autun, in Burgundy, the sites chosen for the establishment of monasteries can be partly determined by their functions, more or less restrictive. The most frequent in the cities are communities of monks settled in the seventh-eighth centuries to serve a funerary basilica or a tomb. This function involves an extra muros situation whatever the age of the foundation of the basilica. Inside the cities, truly monasteries, that is to say, communities of ascetics, are few; these are located outside the walls, but, although isolated from the city by the rampart, these remain in contact with it by symbolic functions. Unlike that is attested in Autun …
Diverse yet similar : English teachers' conceptions of multicultural teaching and pupils of multicultural background
2010
Maahanmuuttajien määrä Suomessa on kasvanut viimeisten kahden vuosikymmenen aikana merkittävästi. Tämä on vaikuttanut myös suomalaisten koulujen väestörakenteeseen ja sitä kautta opettajien työhön. Tämän tutkielman tarkoituksena on selvittää, millaiset käsitykset yläkoulun englannin opettajilla on monikulttuurisesta opetuksesta ja maahanmuuttajaoppilaista ja miten he ovat selviytyneet opettajan arjesta monikielisessä luokkaympäristössä. Teoriataustan valossa tutkimuksessa haetaan vastauksia seuraaviin kysymyksiin: 1) Mitä englannin opettajat käsittävät termillä monikulttuurinen opetus? 2) Millaista englannin opettaminen heidän mielestään monikulttuurisessa luokkaympäristössä on? ja 3) Mitkä…