Search results for "migration"
showing 10 items of 1709 documents
Mast Cells Induce Migration of Dendritic Cells in a Murine Model of Acute Allergic Airway Disease
2009
<i>Background: </i>The migration of dendritic cells (DCs) from the lungs to the regional lymph nodes is necessary for the development of allergic airway disease. Following activation, mast cells release a variety of stored or de novo-produced inflammatory mediators, several of them being capable of activating DCs. In this study, the role of mast cells on DC migration from the lungs to the thoracic lymph nodes was investigated in sensitized mice. <i>Methods:</i> Mast cell-deficient mice (Kit<sup>W-sh/W-sh</sup>) and their wild-type counterparts were sensitized intraperitoneally with ovalbumine (OVA) in saline and challenged by a single intranasal administr…
Progressive Era Racism and its (Jewish) Discontents
2018
This work analyzes the contribution to the debates on labor and immigration of a group of Jewish academicians and reformers who, during the second half of the Progressive Era, explicitly took a stance against the racialist and eugenic rhetoric of the period. This group includes first-rank economists like Edwin R. A. Seligman, Jacob H. Hollander, and Emanuel A. Goldenweiser; influential field specialists such as Isaac A. Hourwich and Isaac M. Rubinow; and relatively less known figures like Max J. Kohler and Samuel K. Joseph. By focusing on the voices of these dissenters, the work enriches the emerging picture of Progressive Era eugenic and racial thought
Wesley Clair Mitchell and the “Illiberal Reformers”: A Documentary Note
2021
In this note we inquire whether Mitchell as a reformer ever expressed concern over the biological quality of individuals and whether he did somehow share the Progressive Era faith in eugenics as an instrument for improving American society’s health, welfare, and morals. This is an aspect of Mitchell’s thought that has received scant attention in the literature and that projects him into the current debate on progressivism.
Déterminants sociaux, scolaires et contextuels de la réussite académique dans le premier cycle universitaire : enfants issus de l’immigration
2020
L’étude vise à analyser les conditions de vie et d’études des étudiants dans le premier cycle universitaire et les variables qui déterminent la réussite académique. Il en ressort des différentes formes de réussite en fonction de l’origine migratoire qui est une dimension de la variable origine sociale. Les étudiants ayant une ascendance immigrée réussissent moins bien que leurs homologues autochtones. L’étude a également permis de mettre en exergue l’importance des caractéristiques sociodémographiques et scolaires dans la réussite académique. La catégorie socioprofessionnelle des parents, le passé scolaire et le degré de satisfaction que l’étudiant déclare avoir de sa formation sont des fac…
Could beta-catenin regulate the expression of proteolitic enzymes during angiogenesis?
2009
During angiogenesis several modifications occurs at endothelial cell plasma membrane level as: MT-MMPs and serine integral membrane proteases (SIMPs) over-expression. Moreover, when endothelial cells during angiogenesis acquired a mesenchymal phenotype the cell-cell interactions mediate by cadherins are lost and β-catenin, a stabilizer of interaction occurring between cadherins and cytoscheleton, can translocate to the nucleus where acts as transcription factor in association to TCF/LEF. Our experiments were focalized to the expression/activation of proteolytic enzymes when cell-cell contacts are perturbed, by mechanical or site specific perturbations. We have analyzed the mRNA, proteins an…
The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development
2014
Low density lipoprotein receptor-related protein 1 (LRP1) is indispensable for embryonic development. Comparing different genetically engineered mouse models, we found that expression of Lrp1 is essential in the embryo proper. Loss of LRP1 leads to lethal vascular defects with lack of proper investment with mural cells of both large and small vessels. We further demonstrate that LRP1 modulates Gi-dependent sphingosine-1-phosphate (S1P) signaling and integrates S1P and PDGF-BB signaling pathways, which are both crucial for mural cell recruitment, via its intracellular domain. Loss of LRP1 leads to a lack of S1P-dependent inhibition of RAC1 and loss of constraint of PDGF-BB-induced cell migra…
Animal Perception of Seasonal Thresholds: Changes in Elephant Movement in Relation to Rainfall Patterns
2012
Background The identification of temporal thresholds or shifts in animal movement informs ecologists of changes in an animal’s behaviour, which contributes to an understanding of species’ responses in different environments. In African savannas, rainfall, temperature and primary productivity influence the movements of large herbivores and drive changes at different scales. Here, we developed a novel approach to define seasonal shifts in movement behaviour by examining the movements of a highly mobile herbivore (elephant; Loxodonta africana), in relation to local and regional rainfall patterns. Methodology/Principal Findings We used speed to determine movement changes of between 8 and 14 GPS…
Macrophage Migration Inhibitory Factor Induces Inflammation and Predicts Spinal Progression in Ankylosing Spondylitis
2017
Objective: To investigate the role of macrophage migration inhibitory factor (MIF) in the pathogenesis of ankylosing spondylitis (AS). Methods: Patients who met the modified New York criteria for AS were recruited for the study. Healthy volunteers, rheumatoid arthritis patients, and osteoarthritis patients were included as controls. Based on the annual rate of increase in modified Stoke AS Spine Score (mSASSS), AS patients were classified as progressors or nonprogressors. MIF levels in serum and synovial fluid were quantitated by enzyme-linked immunosorbent assay. Predictors of AS progression were evaluated using logistic regression analysis. Immunohistochemical analysis of ileal tissue was…
Living in urban interstices: the survival practices of excluded Gypsies in Italian borderlands.
2012
The paper focuses on the case-studies of nomad camps in Italy, where groups of “gypsies” live in condition of ghetto. The nomad camps generally constitute a world out of the city, as an encompassed microcosm. They represent a borderland or a grey zone. The only interaction between “them” and “us” happens when Romanì exit from the camp and cross the municipal streets. Roma people develop a capacity to survive in urban interstices. These practices consist in unusual welfare forms of material help for day by day survival, while living in a condition of human rights negation by majority society members.
Migration of Leukocytes into Filters Coated Homogeneously with Immune Complexes, Antigens, Lectins or Tripeptides
1980
Cellulose nitrate filters were incubated in solutions of albumin, a chemotactically active tripeptide (f-Met-Leu-Phe), immune complexes or lectins and afterwards washed with buffer. They showed a dose-dependent increased leukocyte migration, when tested in typical Boyden chambers in comparison to filters treated only with buffer. The tripeptide, the immune complexes and the lectins were stimulatory at very low concentrations and acted inhibitory at high concentrations. Treating filters with formaldehyde or glutardialdehyde had no clear stimulatory effect. These findings extend earlier observations obtained with casein. They show that cells move very effectively on solid substrata in the abs…