Search results for "mit"

El arte de la platería en la Concatedral de San Nicolás de Alicante

2020

The Co-cathedral of San Nicolás de Alicante still preserves an important treasure of pieces of silverware, ranging from the 17th to the 20th centuries, although the greatest development was known during the 18th century, with sumptuous commissions to the most prominent silversmiths both locally as at regional and national level. In this way, it can be said that the Alicante trousseau is a good example of a temple that, once built, focuses its efforts on the collection of silverware objects that enhance the cult and its ceremonies.

A note on best proximity point theory using proximal contractions

2018

In this paper, a reduction technique is used to show that some recent results on the existence of best proximity points for various classes of proximal contractions can be concluded from the corresponding results in fixed point theory.

Best proximity point theorems for proximal cyclic contractions

2017

The purpose of this article is to compute a global minimizer of the function $$x\longrightarrow d(x, Tx)$$ , where T is a proximal cyclic contraction in the framework of a best proximally complete space, thereby ensuring the existence of an optimal approximate solution, called a best proximity point, to the equation $$Tx=x$$ when T is not necessarily a self-mapping.

Climate Change and Disasters

2017

Ideas and approaches proven successful within disaster risk reduction (DRR) literature and practice are either bypassed or inadequately considered by contemporary climate change work. This chapter explores the intersections between climate change and hazards, vulnerability, and risk, looking at climate change as both a hazard driver and a hazard inhibitor. The implications of the narrow interpretations of vulnerability employed in climate change work are examined, as well as the ways in which climate change has come to act as a scapegoat for issues, events, and processes caused by hazard-independent factors. The chapter formulates a case for climate change adaptation (CCA) to be seen as a s…

"Free or Perforator-Pedicled Propeller Flaps in Lower Extremity Reconstruction: Defining the Coverage Failure": Response.

2018

Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent

2019

Cattle were domesticated ∼10,000 years ago, but analysis of modern breeds has not elucidated their origins. Verdugo et al. performed genome-wide analysis of 67 ancient Near Eastern Bos taurus DNA samples. Several populations of ancient aurochs were progenitors of domestic cows. These genetic lineages mixed ∼4000 years ago in a region around the Indus Valley. Interestingly, mitochondrial analysis indicated that genetic material likely derived from arid-adapted Bos indicus (zebu) bulls was introduced by introgression.Science, this issue p. 173Genome-wide analysis of 67 ancient Near Eastern cattle, Bos taurus, remains reveals regional variation that has since been obscured by admixture in mode…

Assessing the Histone Deacetylase Activity of SIRT6 in Primary Murine Hepatocytes via Proximity Ligation Assay

2016

Generation of primary cell culture of hepatocytes by mouse liver perfusion (MLP) combines the advantages of in vivo and in vitro models. It provides hepatocytes that grow under physiological conditions in mice, with the genotype of the whole organism or a specific gene knockout. In contrast to immortalized cell cultures, primary murine hepatocytes (pmHep) are non-cancerous cells with a limited lifespan but still amenable to classical in vitro methods such as treatment with drugs, small molecule inhibitors, and agonistic/antagonistic antibodies of surface receptors as well as transfection. One technique, which has gained popularity recently, is the analysis of protein-protein interactions by…

Novel Autotrophic Organisms Contribute Significantly to the Internal Carbon Cycling Potential of a Boreal Lake

2018

ABSTRACT Oxygen-stratified lakes are typical for the boreal zone and also a major source of greenhouse gas emissions in the region. Due to shallow light penetration, restricting the growth of phototrophic organisms, and large allochthonous organic carbon inputs from the catchment area, the lake metabolism is expected to be dominated by heterotrophic organisms. In this study, we test this assumption and show that the potential for autotrophic carbon fixation and internal carbon cycling is high throughout the water column. Further, we show that during the summer stratification carbon fixation can exceed respiration in a boreal lake even below the euphotic zone. Metagenome-assembled genomes an…

Melatonin Targets Metabolism in Head and Neck Cancer Cells by Regulating Mitochondrial Structure and Function.

2021

This study was funded by grants from the Ministerio de Economia, Industria y Competitividad y por el Fondo de Desarrollo Regional FEDER, Spain nº SAF2013-49019, SAF2017-85903-P, and from the Consejería de Innovación, Ciencia y Empresa, Junta de Andalucía (P07- CTS- 03135, P10- CTS- 5784, and CTS- 101), Spain. J.F. and L.M. have FPU fellowships from the Ministerio de Educación Cultura y Deporte, Spain. C.R.S. was a schorlarship holder from the Plan Propio de Investigación of the University of Granada.

Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels…

2016

Journal Article; Exposure to unbalanced diets during pre-gestational and gestational periods may result in long-term alterations in metabolism and behavior. The contribution of the endocannabinoid system to these long-term adaptive responses is unknown. In the present study, we investigated the impact of female rat exposure to a hypercaloric-hypoproteic palatable diet during pre-gestational, gestational and lactational periods on the development of male offspring. In addition, the hypothalamic and hippocampal endocannabinoid contents at birth and the behavioral performance in adulthood were investigated. Exposure to a palatable diet resulted in low weight offspring who exhibited low hypotha…