Search results for "mito"

showing 10 items of 2513 documents

Early induction of genetic instability and apoptosis by arsenic in cultured Chinese hamster cells

2002

In order to assess at what time from the beginning of exposure inorganic arsenic can give rise to genetic instability and trigger apoptosis, V79-C13 Chinese hamster cells were treated with 10 microM sodium arsenite for 24 h. Under these conditions, cell survival was >70% and cells showed neither an increase in chromosome aberration frequency nor a delay in cell cycle progression. Investigations, which were carried out every 6 h during the treatment, revealed an early appearance of genetically unstable cells, namely micronucleated, multinucleated and mononucleated 'giant' cells, as well as apoptotic cells. Indirect immunostaining using anti-beta-tubulin antibody showed severe alterations in …

ArsenitesCell SurvivalHealth Toxicology and MutagenesisPopulationMitosisHamsterApoptosisToxicologyChromosome aberrationChromosomesChinese hamsterCricetulusMultinucleateCricetinaeGeneticsAnimalseducationMitosisGenetics (clinical)Chromosome Aberrationseducation.field_of_studybiologyAneuploidybiology.organism_classificationSodium CompoundsMolecular biologyCell biologySettore BIO/18 - GeneticaCell cultureApoptosisCytogenetic AnalysisMutationarsenic genomic instability apoptosisFluorescein-5-isothiocyanate
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Del héroe épico al héroe trágico: la progresión de los planteamientos éticos en la Ilíada

2019

Na Ilíada, em alguns dos seus heróis mais relevantes, podemos ver a transição de uma cultura em que o ser humano é um objeto nas mãos dos deuses ou do destino para uma posição em que o ser humano assume a responsabilidade no contexto de uma interação entre o plano humano e o plano divino, posição em que atuaram, nos seus respetivos pressupostos dramáticos, os heróis de Ésquilo e também os de Sófocles e os de Eurípides.

Art i mitologia
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Effects of tributyltin(IV) chloride on fertilization of Styela plicata (Ascidiacea: Tunicata): II. Scanning and transmission electron microscopy stud…

2003

The morphological aspects of Styela plicata fertilization after treatment with tributyltin(IV) chloride are described by means of scanning and transmission electron microscopy investigations. Alterations have been shown both on female and male gametes; spermatozoa, all the egg envelopes and the mitochondria of the egg cortical cytoplasm are modified in relation to incubation time. As a consequence, the damage to gametes blocks sperm-egg interaction and fertilization does not occur. Copyright © 2003 John Wiley & Sons, Ltd.

Ascidiangameteanimal cellstyela plicataincubation timespermspecieanimal tissueInorganic Chemistrymalemorphologytransmission electron microscopytributyltin chloridemitochondrioncontrolled studyoocytevitelline membranenonhumanarticleoocyte cortexfemalespermatozoonTributyltin(IV) chlorideChemistry (miscellaneous)fertilizationSettore CHIM/03 - Chimica Generale E Inorganicacytoplasmovary follicle cellscanning electron microscopyAscidiacea
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A molecular phylogeny of bullfinches Pyrrhula Brisson, 1760 (Aves: Fringillidae)

2011

Abstract We present a molecular phylogeny of bullfinches (Pyrrhula Brisson, 1760) based on 2357 bp DNA sequence information of mitochondrial genes (cyt-b, 16S rRNA) and nuclear introns (fib-7, GAPDH-11). The genus is clearly a monophyletic group. Within the limits of Pyrrhula, molecular methods support the subdivision of three main groups: (1) “Southeast-Asian bullfinches” (P. nipalensis and P. leucogenis), (2) “Himalayan bullfinches” (P. aurantiaca, P. erythaca, P. erythrocephala), and (3) “Eurasian bullfinches” (P. pyrrhula s.l.). Within the last group there are four different subgroups: (3a) P. (p.) murina, (3b) P. (p.) cineracea, (3c) P. (p.) griseiventris, and (3d) P. pyrrhula s.str. T…

AsiaPyrrhulaBiogeographyZoologyPinicolaBiologyDNA MitochondrialCoalescent theoryEvolution MolecularMonophylyGenusRNA Ribosomal 16SGeneticsAnimalsMolecular clockMolecular BiologyPhylogenyEcology Evolution Behavior and SystematicsCell NucleusGenetic VariationSequence Analysis DNAbiology.organism_classificationIntronsEuropeMolecular phylogeneticsFinchesMolecular Phylogenetics and Evolution
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The mitochondrial‐derived peptide MOTS ‐c: a player in exceptional longevity?

2015

Mitochondrial-derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA-c (MOTS-c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS-c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people. 5.760 JCR (2015) Q1, 36/187 Cell biology, 3/49 Geriatrics & gerontology UEM

Asian Continental Ancestry GroupAgingMitochondrial DNAMitochondrial-Derived Peptide MOTS-cBiologíamedia_common.quotation_subjectLongevityMolecular biology of agingmitochondrial DNAGenética humanaMitochondrionBiologyDNA MitochondrialPolymorphism Single Nucleotidelongevity geneOpen Reading FramesAsian PeopleJapanCentenariansHumansmolecular biology of agingBiología humanaHumaninmedia_commonGeneticsBiología molecularGenMitochondrial DNA abnormalitiesLongevityCell Biologylongevity regulationLongevity geneMitochondrial DNAmitochondrial DNA abnormalitiesMitochondriaLongevity regulationOpen reading frameRNA RibosomalCommentaryAsian populationcentenariansPeptidesAging Cell
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The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape

2015

Summary Over the past few years, studies of DNA isolated from human fossils and archaeological remains have generated considerable novel insight into the history of our species. Several landmark papers have described the genomes of ancient humans across West Eurasia, demonstrating the presence of large-scale, dynamic population movements over the last 10,000 years, such that ancestry across present-day populations is likely to be a mixture of several ancient groups [1, 2, 3, 4, 5, 6, 7]. While these efforts are bringing the details of West Eurasian prehistory into increasing focus, studies aimed at understanding the processes behind the generation of the current West Eurasian genetic landsc…

Asian Continental Ancestry GroupGene FlowGenetics and Molecular Biology (all)genetics and molecular biologyEvolutionHuman MigrationEuropean Continental Ancestry GroupPopulationSettore BIO/08 - ANTROPOLOGIABiologyDNA MitochondrialBiochemistryArticleWhite PeopleGeneral Biochemistry Genetics and Molecular BiologyEvolution MolecularArcheology Eurasia.Henomics AdmixtureAsian PeopleSettore BIO/13 - Biologia ApplicataReportGeneticsHumansComputer Simulationagricultural and biological sciencesPhylogenyAgricultural and Biological Sciences(all)Biochemistry Genetics and Molecular Biology(all)FossilsGenetic VariationMolecularDNAGenomicsMitochondrialAsian Continental Ancestry Group; Computer Simulation; DNA Mitochondrial; European Continental Ancestry Group; Fossils; Genetic Variation; Genetics Population; Genomics; Haplotypes; Humans; Phylogeny; Evolution Molecular; Gene Flow; Human Migration; Biochemistry Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)Genetics PopulationHaplotypesAgricultural and Biological Sciences (all)Evolutionary biologyadmixtureCurrent (fluid)agricultural and biological sciences; biochemistry; genetics and molecular biologyGeneral Agricultural and Biological ScienceseuropeCurrent Biology
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Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothal…

2015

Endocannabinoids participate in the control of neurogenesis, neural cell death and gliosis. The pharmacological effect of the fatty acid amide hydrolase (FAAH) inhibitor URB597, which limits the endocannabinoid degradation, was investigated in the present study. Cell proliferation (phospho-H3(+) or BrdU(+) cells) of the main adult neurogenic zones as well as apoptosis (cleaved caspase-3(+)), astroglia (GFAP(+)), and microglia (Iba1(+) cells) were analyzed in the hippocampus, hypothalamus and striatum of rats intraperitoneally treated with URB597 (0.3 mg/kg/day) at one dose/4-days resting or 5 doses (1 dose/day). Repeated URB597 treatment increased the plasma levels of the N-acylethanolamine…

AstrocitosNeurobiologia del desenvolupamentAmidohidrolasasCannabinoid receptorCarbamatos:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::Apoptosis Regulatory Proteins::Caspases [Medical Subject Headings]:Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation::Neurogenesis [Medical Subject Headings]medicine.medical_treatment:Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose [Medical Subject Headings]Apoptosis:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight [Medical Subject Headings]chemistry.chemical_compound:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Membrane Proteins::Receptors Cell Surface::Receptors G-Protein-Coupled::Receptors Cannabinoid::Receptor Cannabinoid CB1 [Medical Subject Headings]0302 clinical medicine:Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids Acyclic::Carbamates [Medical Subject Headings]Fatty acid amide hydrolaseReceptor cannabinoide CB1:Organisms::Eukaryota::Animals [Medical Subject Headings]FAAHGliosishealth care economics and organizations:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleosides::Deoxyribonucleosides::Deoxyuridine::Bromodeoxyuridine [Medical Subject Headings]:Chemicals and Drugs::Lipids::Glycerides::Triglycerides [Medical Subject Headings]Original Research0303 health sciencesNeurogenesisBenzamidas:Chemicals and Drugs::Polycyclic Compounds::Steroids::Cholestanes::Cholestenes::Cholesterol [Medical Subject Headings]Endocannabinoid systemEtanolaminas3. Good healthEndocannabinoides:Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Unsaturated::Fatty Acids Monounsaturated::Oleic Acids [Medical Subject Headings]CannabinoidesMicroglíalipids (amino acids peptides and proteins)medicine.symptomColesterol:Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Terpenes::Cannabinoids [Medical Subject Headings]:Chemicals and Drugs::Lipids::Fatty Acids::Palmitic Acids [Medical Subject Headings]psychological phenomena and processesProliferación celularmedicine.medical_specialtyCerebroNeurogenesiseducationBiologyBromodesoxiuridina:Anatomy::Nervous System::Neuroglia::Microglia [Medical Subject Headings]Triglicéridoslcsh:RC321-571Ácidos oléicosRatas03 medical and health sciencesCellular and Molecular NeuroscienceInternal medicineHipocampomedicineCaspasa 3:Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus [Medical Subject Headings]:Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation [Medical Subject Headings]lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry030304 developmental biologyPalmitoylethanolamide:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Endocannabinoids [Medical Subject Headings]:Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Amidohydrolases [Medical Subject Headings]Cannabinoids:Anatomy::Cells::Neuroglia::Astrocytes [Medical Subject Headings]Peso corporalEnergy metabolism:Anatomy::Nervous System::Central Nervous System::Brain [Medical Subject Headings]:Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hypothalamus [Medical Subject Headings]URB597:Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death [Medical Subject Headings]:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Gliosis [Medical Subject Headings]:Chemicals and Drugs::Organic Chemicals::Amines::Amino Alcohols::Ethanolamines [Medical Subject Headings]Muerte celular:Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats [Medical Subject Headings]EndocrinologyURB597chemistryGliosisnervous systemGlucosaCannabinoidEnergy Metabolism:Chemicals and Drugs::Organic Chemicals::Amides::Benzamides [Medical Subject Headings]HipotálamoÁcidos palmíticos030217 neurology & neurosurgeryNeuroscienceFrontiers in Cellular Neuroscience
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C. Iulii Hygini... Fabularum liber... ; Eiusdem Poeticon Astronomicon Libri quatuor.

Sign.: [alfa]4, a-y6, z8 Palaephati De fabulosis narrationibus Liber I. Fulgentii... Mythologiarum Libri III [i] De vocum antiquarum interpretatione Liber I. Phurnuti De natura deorum... speculatio. Albrici De deorum imaginibus Liber. Arati Phainomenon fragmentum... Procli De sphaera libellus Les il. són grav. xil Text amb postil·les marginals

Astronomia Obres anteriors al 1800Mitologia clàssica
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Causative role of oxidative stress in a Drosophila model of Friedreich ataxia

2006

Friedreich ataxia (FA), the most common form of hereditary ataxia, is caused by a deficit in the mitochondrial protein frataxin. While several hypotheses have been suggested, frataxin function is not well understood. Oxidative stress has been suggested to play a role in the pathophysiology of FA, but this view has been recently questioned, and its link to frataxin is unclear. Here, we report the use of RNA interference (RNAi) to suppress the Drosophila frataxin gene (fh) expression. This model system parallels the situation in FA patients, namely a moderate systemic reduction of frataxin levels compatible with normal embryonic development. Under these conditions, fh-RNAi flies showed a shor…

AtaxiaBlotting WesternLongevityGene ExpressionCHO Cellsmedicine.disease_causeBiochemistryAconitaseMitochondrial ProteinsCricetulusRNA interferenceCricetinaeIron-Binding ProteinsGeneticsmedicineAnimalsDrosophila ProteinsRNA MessengerMolecular BiologyGeneAconitate HydrataseHyperoxiaGeneticsElectron Transport Complex IbiologyReverse Transcriptase Polymerase Chain ReactionSuccinate dehydrogenasefungiImmunohistochemistryCell biologySuccinate DehydrogenaseOxidative StressDrosophila melanogasterFriedreich AtaxiaFrataxinbiology.proteinRNA Interferencemedicine.symptomOxidative stressBiotechnologyThe FASEB Journal
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Deferiprone and idebenone rescue frataxin depletion phenotypes in a Drosophila model of Friedreich's ataxia

2013

Friedreich's ataxia (FRDA), the most common inherited ataxia, is a neurodegenerative disease caused by a reduction in the levels of the mitochondrial protein frataxin, the function of which remains a controversial matter. Several therapeutic approaches are being developed to increase frataxin expression and reduce the intramitochondrial iron aggregates and oxidative damage found in this disease. In this study, we tested separately the response of a Drosophila RNAi model of FRDA ( Llorens et al., 2007) to treatment with the iron chelator deferiprone (DFP) and the antioxidant idebenone (IDE), which are both in clinical trials. The FRDA flies have a shortened life span and impaired motor coord…

AtaxiaPyridonesUbiquinoneIronLife spanHyperoxiaBiologyPharmacologyMitochondrionmedicine.disease_causeAconitaseAntioxidantsAconitasechemistry.chemical_compoundIron-Binding ProteinsGeneticsmedicineAnimalsIdebenoneDeferiproneAconitate HydrataseHyperoxiaFrataxinClimbing capabilityGeneral MedicineMitochondriaDisease Models AnimalOxidative StressPhenotypechemistryFriedreich AtaxiaOxidative stressMutationFrataxinbiology.proteinDrosophilamedicine.symptomDeferiproneOxidative stressmedicine.drugGene
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