Search results for "modality."

Chapter 12. Multimodal measurement of cognitive load during subtitle processing

2018

International validation of the revised European Organisation for Research and treatment of cancer head and neck cancer module, the EORTC QLQ-HN43

2019

Background: We validated the new European Organisation for Research and Treatment of Cancer Quality of Life Head and Neck Module (EORTC QLQ-HN43). Methods: We enrolled 812 patients with head and neck cancer from 18 countries. Group 1 completed the questionnaire before therapy, and 3 and 6 months later. In group 2 (survivors), we determined test–retest reliability using intraclass correlation coefficients (ICC). Internal consistency was assessed using Cronbach's Alpha, the scale structure with confirmatory factor analysis, and discriminant validity with known-group comparisons. Results: Cronbach's alpha was >0.70 in 10 of the 12 multi-item scales. All standardized factor loadings exceeded…

A GIS-Based Methodology for Evaluating the Increase in Multimodal Transport between Bicycle and Rail Transport Systems. A Case Study in Palermo

2021

Background: In a world where every municipality is pursuing the goals of more sustainable mobility, bicycles play a fundamental role in getting rid of private cars and travelling by an eco-friendly mode of transport. Additionally, private and shared bikes can be used as a feeder transit system, solving the problem of the first- and last-mile trips. Thanks to GIS (Geographic Information System) software, it is possible to evaluate the effectiveness of such a sustainable means of transport in future users’ modal choice. Methods: Running an accessibility analysis of cycling and rail transport services, the potential mobility demand attracted by these services and the possible multimodality bet…

Communicating Medical Information Online: The Case of Adolescent Health Websites

2020

In recent times, our understanding and practice of public health has been increasingly guided by technological advances generally based on governmental decisions (Green et al. 2009). Not only does the growth of a public system for protecting health hinge upon scientific discovery and dissemination of medical knowledge, but also the World Wide Web has considerably changed the health communication environment. This paper considers the online health information addressed to adolescents. Given that young people have difficulty accessing traditional health services, in theory, the Internet might offer them a more confidential and convenient access to an unprecedented level of information about a…

Comparison of canonical variate analysis and principal component analysis on 422 descriptive sensory studies

2015

International audience; Although Principal Component Analysis (PCA) of product mean scores is most often used to generate a product map from sensory profiling data, it does not take into account variance of product mean scores due to individual variability. Canonical Variate Analysis (CVA) of the product effect in the two-way (product and subject) multivariate ANOVA model is the natural extension of the classical univariate approach consisting of ANOVAs of every attribute. CVA generates successive components maximizing the ANOVA F-criterion. Thus, CVA is theoretically more adapted than PCA to represent sensory data. However, CVA requires a matrix inversion which can result in computing inst…

Development of functionalizable azaBODIPYs for the conception of theranostic agents and bimodal probes for imaging uses

2020

The in vivo use of optical imaging is still limited by the lack of near infrared emitting probes. This thesis work focuses on the optimization and valorization of a water-soluble fluorescent platform whose optical properties enable an in vivo use. Two distinct applications were investigated for this WazaBY (Water-soluble azaBODIPY) platform: use as a PET (or SPECT) / optical bimodal probe, and as a theranostic agent. Concerning the first project, we were able to develop a targetted SPECT/optical bimodal probe, which was radiometallated with indium 111. Using xenografted murine models, we were able to show a clear accumulation of the probe in the tumor 24 hours after injection. Moreover, the…

Damage to the urinary tract secondary to irradiation.

1995

During the past two decades, highly effective multimodality therapy with surgery, chemotherapy and irradiation has been developed through consecutive national and international study protocols for childhood genitourinary cancers, the model being Wilms' tumor. These studies represent a landmark achievement in the history of pediatric oncology and mark the success of multi-institutional efforts. Now that excellent survival rates have been established, current interest is now directed primarily at examination of survivors for long-term treatment complications and minimizing the side effects while preserving treatment efficacy. Treatment sequelae may not become evident until many years after th…

Progress and controversies in modern treatment of Wilms' tumors.

1995

During the past 25 years the treatment of Wilms' tumors has been refined owing to a series of thoroughly performed clinical studies. The overall prognosis is currently 80% (long-term cures), but different therapeutic issues are still discussed controversially, especially the question of preoperative treatment. A number of different drugs have proved effective in the treatment of Wilms' tumors. It remains to be determined as to which drug combinations are the most effective for which histologic subtype and which stage of disease. It seems that these questions can be answered only if further studies consequently implicate analyses of early and long-term toxicities. The same is true for analys…

Pediatric urological cancer.

1995

Correlation between clinical response and urinary interleukin levels using different doses and intravesical administration schedules of interferon-al…

1993

A total of 62 patients at high risk for recurrence of superficial bladder cancer were selected for a study designed to compare the prophylactic efficacy of different doses and schedules of sequential intravesical instillations of epirubicin and interferon-alpha-2b and to evaluate which sequence could enhance the release of cytokines in the urine. Our investigations showed a significant increase in urinary concentrations of interleukins in patients who received the sequential intravesical administration of epirubicin and interferon-alpha-2b. Higher urinary concentrations of interleukins and a lower recurrence rate were detected in patients who received interferon-alpha-2b 24 h after epirubic…