6533b7cffe1ef96bd1259915
RESEARCH PRODUCT
International validation of the revised European Organisation for Research and treatment of cancer head and neck cancer module, the EORTC QLQ-HN43
Susanne SingerCecilie Delphin AmdalEva HammerlidIwona M TomaszewskaJoaquim Castro SilvaHisham MehannaMarcos SantosJohanna InhesternChristine BrannanNoam YaromAmy FullertonMonica PintoJuan I ArrarasNaomi KiyotaPierluigi BonomoAllen C ShermanIngo BaumannRazvan GalalaeLoreto Fernandez GonzalezOurania Nicolatou-galitisZeinab Abdel-hafeezJudith Raber-durlacherClaudia SchmalzPaola ZottiAndreas BoehmDirk HofmeisterSanja Krejovic TrivicSuat LooWei-chu ChieKristin BjordalBente Brokstad HerlofsonVincent GrégoireLisa LicitraEortc Quality Of Life And The Eortc Head And Neck Cancer Groupssubject
Multimodal therapiesQuality of lifeMalemedicine.medical_specialtySDG 16 - PeacePsychometricsIntraclass correlationMedizinSensitivity and Specificity03 medical and health sciences0302 clinical medicineCronbach's alphaQuality of lifeSurveys and QuestionnairesValidationOutcome Assessment Health CaremedicineHumansProspective Studies030212 general & internal medicineHead and neck cancerReliability (statistics)AgedAged 80 and overbusiness.industryHead and neck cancerSDG 16 - Peace Justice and Strong InstitutionsDiscriminant validityReproducibility of ResultsCancerMiddle Agedmedicine.diseaseCombined Modality Therapy/dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutionsConfirmatory factor analysishumanitiesJustice and Strong Institutions3. Good healthEuropeChemoradiationOtorhinolaryngologyHead and Neck Neoplasms030220 oncology & carcinogenesisQuality of LifePhysical therapyFemalebusinessdescription
Background: We validated the new European Organisation for Research and Treatment of Cancer Quality of Life Head and Neck Module (EORTC QLQ-HN43). Methods: We enrolled 812 patients with head and neck cancer from 18 countries. Group 1 completed the questionnaire before therapy, and 3 and 6 months later. In group 2 (survivors), we determined test–retest reliability using intraclass correlation coefficients (ICC). Internal consistency was assessed using Cronbach's Alpha, the scale structure with confirmatory factor analysis, and discriminant validity with known-group comparisons. Results: Cronbach's alpha was >0.70 in 10 of the 12 multi-item scales. All standardized factor loadings exceeded 0.40. The ICC was >0.70 in all but two scales. Differences in scale scores between known-groups were >10 points in 17 of the 19 scales. Sensitivity to change was found to be sufficient in 18 scales. Conclusions: Evidence supports the reliability and validity of the EORTC QLQ-HN43 as a measure of quality of life.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-06-01 | Head and Neck |