0000000000109639

AUTHOR

Noam Yarom

showing 6 related works from this author

Adverse Reactions to Anticancer Drugs in the Oral Cavity

2018

The development, testing, and adoption into clinical practice of anticancer medications have revolutionized cancer care over the past decades. A better understanding of the biology of cancer has translated into development of novel systemic agents, as well a more effective use of older chemotherapy agents. As a consequence, cancer mortality continues to decrease. However, greater cure and disease control rates come at a price of an increased risk of adverse effects, which often affects the mouth and related structures including the oral mucosa, salivary glands, jawbones, and cranial nerves. Oral mucositis, hyposalivation, dysgeusia, and osteonecrosis of the jaw (ONJ) are some examples of th…

MouthArticle SubjectGeneral Immunology and Microbiologybusiness.industrylcsh:RMEDLINElcsh:MedicineAntineoplastic AgentsGeneral MedicineOral cavityBioinformaticsGeneral Biochemistry Genetics and Molecular BiologyEditorialText miningHumansMedicineMouth DiseasesbusinessBioMed Research International
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Does age matter?: A comparison of health‐related quality of life issues of adolescents and young adults with cancer

2018

Objective:Health‐related quality of life (HRQoL) concerns of adolescents and young adults (AYAs) aged 14–25 years were compared with those of older adults (26–60 years) with cancer.Methods:AYAs and older adults receiving curative intent treatment or supportive palliative care for cancer were recruited from eight research centres across Europe. Participants used a rating scale to score the relevance and importance of a list of 77 issues covering 10 areas of HRQoL concern: symptoms; activity restrictions; social; emotional; body image; self‐appraisals; outlook on life; lifestyle; treatment‐related and life beyond treatment.Results:HRQoL issues were reviewed by 33 AYAs and 25 older adults. Sev…

GerontologyAdultMalePalliative careActivities of daily livingAdolescentmedia_common.quotation_subjectHealth StatusEmotionsPsycho-oncologyFertility03 medical and health sciencesYoung Adult0302 clinical medicineQuality of life (healthcare)Rating scaleNeoplasmsActivities of Daily LivingBody ImageMedicineHumans030212 general & internal medicineYoung adultLife Stylemedia_commonbusiness.industryAge FactorsMiddle AgedSocial ParticipationSelf ConcepthumanitiesOncologyAttitude030220 oncology & carcinogenesisQuality of LifeFemalebusinessPsychosocialRare cancers Radboud Institute for Health Sciences [Radboudumc 9]
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Assessing Preferences in Patients with Head and Neck Squamous Cell Carcinoma: Phase I and II of Questionnaire Development.

2020

Shared-decision making for head and neck squamous cell carcinoma (HNSCC) is challenged by the difficulty to integrate the patient perception of value within the framework of a multidisciplinary team approach. The aim of this study was to develop a questionnaire to assess the preferences of HNSCC patients with respect to the disease trajectory, expected treatment, and toxicities. In accordance with the standardized EORTC Quality of Life Group&rsquo

Cancer Researchmedicine.medical_specialtyScoring criteriaDiseaselcsh:RC254-282Article03 medical and health sciences0302 clinical medicineQuality of lifehead and neck cancer; multimodal therapies; patient preferences; patient priorities; quality of lifeHealth caremedicineIn patient030212 general & internal medicinemultimodal therapiesneoplasmsbusiness.industryHead and neck cancermedicine.diseaselcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensHead and neck squamous-cell carcinoma3. Good healthstomatognathic diseasesPatient perceptionsOncologypatient prioritiesquality of life030220 oncology & carcinogenesisFamily medicinehead and neck cancerbusinesspatient preferences
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A life put on pause: an exploration of the health-related quality of life issues relevant to adolescents and young adults with cancer

2018

Purpose: in recent years, the assessment of health-related quality of life (HRQoL) has been recognized as particularly informative to health care providers. For adolescents and young adults (AYAs), the impact of a cancer diagnosis and subsequent treatment is likely to be distinct from other age groups given the unique and complex physical and psychosocial challenges of this developmental phase. The objective of this study was to capture the HRQoL issues described by AYAs with cancer using thematic analysis.Methods: semi-structured interviews were carried out with 45 AYAs aged 14-25 years from 6 countries. Results: the most prevalent cancers presented were leukemia (n=12) and lymphoma (n=8).…

Gerontologybusiness.industryNauseaFamily lifehumanities03 medical and health sciencesAll institutes and research themes of the Radboud University Medical Center0302 clinical medicineQuality of life (healthcare)Oncology030220 oncology & carcinogenesisPediatrics Perinatology and Child HealthMedicineAnxiety030212 general & internal medicineYoung adultmedicine.symptomThematic analysisbusinessPsychosocialDepression (differential diagnoses)Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
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Measuring quality of life in patients with head and neck cancer: Update of the EORTC QLQ-H&N Module, Phase III

2014

Background The objective of this study was to pilot test an updated version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck Module (EORTC QLQ-H&N60). Methods Patients with head and neck cancer were asked to complete a list of 60 head and neck cancer-specific items comprising the updated EORTC head and neck module and the core questionnaire EORTC QLQ-C30. Debriefing interviews were conducted to identify any irrelevant items and confusing or upsetting wording. Results Interviews were performed with 330 patients from 17 countries, representing different head and neck cancer sites and treatments. Forty-one of the 60 items were retain…

medicine.medical_specialtyPsychometricsbusiness.industryDebriefingHead and neck cancerHead necksocial sciencesmedicine.diseasehumanitiesSurgeryOtorhinolaryngologyQuality of lifePhysical therapyMedicineIn patientPilot testbusinessHead and neckHead & Neck
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International validation of the revised European Organisation for Research and treatment of cancer head and neck cancer module, the EORTC QLQ-HN43

2019

Background: We validated the new European Organisation for Research and Treatment of Cancer Quality of Life Head and Neck Module (EORTC QLQ-HN43). Methods: We enrolled 812 patients with head and neck cancer from 18 countries. Group 1 completed the questionnaire before therapy, and 3 and 6 months later. In group 2 (survivors), we determined test–retest reliability using intraclass correlation coefficients (ICC). Internal consistency was assessed using Cronbach's Alpha, the scale structure with confirmatory factor analysis, and discriminant validity with known-group comparisons. Results: Cronbach's alpha was >0.70 in 10 of the 12 multi-item scales. All standardized factor loadings exceeded…

Multimodal therapiesQuality of lifeMalemedicine.medical_specialtySDG 16 - PeacePsychometricsIntraclass correlationMedizinSensitivity and Specificity03 medical and health sciences0302 clinical medicineCronbach's alphaQuality of lifeSurveys and QuestionnairesValidationOutcome Assessment Health CaremedicineHumansProspective Studies030212 general & internal medicineHead and neck cancerReliability (statistics)AgedAged 80 and overbusiness.industryHead and neck cancerSDG 16 - Peace Justice and Strong InstitutionsDiscriminant validityReproducibility of ResultsCancerMiddle Agedmedicine.diseaseCombined Modality Therapy/dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutionsConfirmatory factor analysishumanitiesJustice and Strong Institutions3. Good healthEuropeChemoradiationOtorhinolaryngologyHead and Neck Neoplasms030220 oncology & carcinogenesisQuality of LifePhysical therapyFemalebusinessHead and Neck
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