Search results for "modality."

Strategic Planning for Integrated Mobility-on-Demand and Urban Public Bus Networks

2020

App-based services and ridesharing in the field of mobility-on-demand (MoD) create a new mode of transport between motorized individual transport and public transportation whose long-term role in the urban mobility landscape and within public transport systems is not fully understood as of today. For the public transport industry, these new services offer new chances but also risks, making planning models and tools for integrated intermodal network planning indispensable. We develop a strategic network planning optimization model for bus lines that allows for intermodal trips with MoD as a first or last leg. Starting from an existing public transport network, we decide simultaneously on th…

A Guide to Designing a Memory fMRI Paradigm for Pre-surgical Evaluation in Temporal Lobe Epilepsy

2020

There has been increasing interest in the clinical and experimental use of memory functional Magnetic Resonance Imaging (fMRI). The 2017 American Academy of Neurology practice guidelines on the use of pre-surgical cognitive fMRI suggests that verbal memory fMRI could be used to lateralize memory functions in people with Temporal Lobe Epilepsy (TLE) and should be used to predict post-operative verbal memory outcome. There are however technical and methodological considerations, to optimize both the sensitivity and specificity of this imaging modality. Below we discuss these constraints and suggest recommendations to consider when designing a memory fMRI paradigm.

2018

Despite increasing interest in the development of audiovisual speech perception in infancy, the underlying mechanisms and neural processes are still only poorly understood. In addition to regions in temporal cortex associated with speech processing and multimodal integration, such as superior temporal sulcus, left inferior frontal cortex (IFC) has been suggested to be critically involved in mapping information from different modalities during speech perception. To further illuminate the role of IFC during infant language learning and speech perception, the current study examined the processing of auditory, visual and audiovisual speech in 6-month-old infants using functional near-infrared s…

A critical evaluation of caplacizumab for the treatment of acquired thrombotic thrombocytopenic purpura

2020

Introduction: Acquired thrombotic thrombocytopenic purpura (aTTP) is a thrombotic microangiopathy caused by inhibitory autoantibodies against ADAMTS13 protein. Until recently, the combination of plasma exchange (PEX) and immunosuppression has been the standard front-line treatment in this disorder. However, aTTP-related mortality, refractoriness, and relapse are still a matter of concern. Areas covered: The better understanding of the pathophysiological mechanisms of aTTP has allowed substantial improvements in the diagnosis and treatment of this disease. Recently, the novel anti-VWF nanobody caplacizumab has been approved for acute episodes of aTTP. Caplacizumab is capable to block the adh…

Integrated treatment of first episode psychosis with online training (e-learning): study protocol for a randomised controlled trial

2014

Background: The integrated treatment of first episode psychosis has been shown to improve functionality and negative symptoms in previous studies. In this paper, we describe a study of integrated treatment (individual psychoeducation complementary to pharmacotherapy) versus treatment as usual, comparing results at baseline with those at 6-month re-assessment (at the end of the study) for these patients, and online training of professionals to provide this complementary treatment, with the following objectives: 1) to compare the efficacy of individual psychoeducation as add-on treatment versus treatment as usual in improving psychotic and mood symptoms; 2) to compare adherence to medication,…

Infrastructure as Interface: Thinking the Urban and the High-speed Railway Station: Italian Case-studies

2013

The recent launching in Italy of a number of large scale urban operations centered around High Speed Railway (HSR) stations has added a wealth of examples and themes to the overall European picture; these go to make up a global point of reference for other countries that are, in this period, undertaking the construction of their own HSR networks. Above and beyond the territorial questions often linked to the issue, further research investigating the architectural aspect of these operations would be highly relevant, but is rather lacking. Instead, we shall be focusing on current HSR stations in Italy, such as Turin Porta Susa, Florence Belfiore and Rome Tiburtina, and comparing them briefly,…

Hydrogels in maxillofacial prosthesis

2017

Background: There is a growing need for prosthetic replacements in humans due to various reasons. Oro-facial deformities contribute more for these treatment modalities due to impairment in both function and esthetics. Biomaterials play an important role in replacing any form of defects. Selection of a good biomaterial is of prime importance as these materials determine the success of the treatment outcome. Acrylic resins and silicones are the most popular materials for replacing the lost tissues as far as the maxillofacial prosthesis is concerned. But these materials only help in covering the defect and give a very little therapeutic effect. Acrylic resins are very rigid materials and are l…

Signals of intensification and attenuation in orchestra and choir conduction

2017

Based on a model of communication according to which not only words but also body signals constitute lexicons (Poggi, 2007), the study presented aimes at building a lexicon of conductors’ multimodal behaviours requesting intensification and attenuation of sound intensity. In a corpus of concerts and rehearsals, the conductors’ body signals requesting to play or sing forte, piano, crescendo, diminuendo were analysed through an annotation scheme describing the body signals, their meanings, and their semiotic devices: generic codified (the same as in everyday language); specific codified (shared with laypeople but with specific meanings in conduction); direct iconic, (resemblance between visua…

Classification par méthodes d’apprentissage supervisé et faiblement superviséd’images multimodales pour l’aide au diagnostic du lentigo malin en derm…

2021

Carried out in collaboration with the Saint-Étienne University Hospital, this work provides additional information to help the skin diagnosis by providing new decision methods on Lentigo Maligna and Lentigo Maligna Melanoma pathologies. To this end, the modalities regularly used in clinical conditions are made available to this work and are orchestrated within a multimodal process. Among image modalities, may be mentioned the clinical photography, the dermatoscopy, and the confocal reflectance microscopy. Initially, the first steps of this manuscript focus on reflectance confocal microscopy as the work in computer diagnostic assistance is relatively underdeveloped, in particular on the dete…

Constructing the Moral Order of a Relationship in Couples Therapy

2016

Although couples therapy is rightly seen as one modality of the psychotherapies, many salient aspects of the process are not revealed by psychological theory. These have to do with how, in therapeutic conversations, the couple relationship is presented and performed as a social institution with a particular social and moral order. The moral order of a relationship includes more or less articulated and shared understandings of what is valued and what is not, what are the loyalties, duties, and responsibilities expected from the partners, and the grounds for evaluating actions. It also includes expectations concerning how value, concern, and respect are communicated. In this case study, based…