Search results for "modality."

A multimodality approach to localized rectal cancer.

2006

Transpupillare Thermotherapie (TTT) zur Behandlung von Aderhautmetastasen

2001

Die transpupillare Thermotherapie (TTT) wird erfolgreich zur Behandlung kleiner Aderhautmelanome am hinteren Augenpol eingesetzt [9, 13, 14]. Wir berichten uber die erfolgreiche Behandlung von Aderhautmetastasen mittels TTT unter intravenoser Gabe von Indozyaningrun (ICG). Bei 3 Patienten mit systemisch metastasierenden Karzinomen (Osophagus-, Bronchial- und Mamma-Ca) wurden Aderhautfiliae in 4 Augen mit jeweils einer Sitzung TTT behandelt. Verwendet wurde ein Diodenlaser (810 nm) und Spotgrose 2–3 mm. Die Laserleistung (im Mittel 0,75W) wurde beginnend bei 0,3W in 50 mW Schritten fur jeweils 1 Minute erhoht, bis die Tumoroberflache eine grauweise Odembildung zeigte. Jeweils 1 Minute nach T…

The Addition of Transarterial Chemoembolization to Palliative Chemotherapy Extends Survival in Intrahepatic Cholangiocarcinoma

2021

Incidence and mortality of intrahepatic cholangiocarcinoma (iCCA) have been increasing continuously. Recent studies suggest that the combination of palliative chemotherapy (pCTX) and transarterial chemoembolization (TACE) improves overall survival (OS). This study aimed to evaluate the outcome of patients treated with TACE and pCTX in unresectable iCCA at our tertiary care center. A group of 14 patients was treated with both pCTX and TACE. The non-randomized control group of 59 patients received pCTX alone. Patients received a median of two pCTX lines in both groups. Those treated with TACE underwent a median number of 3.5 sessions. Median OS from the time of unresectability was 26.2 months…

Imaging Approach for Evaluation of Focal Liver Lesions

2009

Focal liver lesions are common in the general population. Radiology (imaging) plays a pivotal role for the diagnosis, staging, treatment planning, and follow-up of focal liver lesions. To maximize lesion detection and characterization, imaging needs to be performed with appropriate equipment by using protocols carefully designed on the basis of the underlying clinical context. In addition, the decision of an imaging modality cannot be based on the diagnostic accuracy of an imaging test solely but must also consider patient safety and cost-effectiveness.

Glutathione, GlutathioneS-Transferase α and π, and Aldehyde Dehydrogenase Content in Relationship to Drug Resistance in Ovarian Cancer

1997

Glutathione, glutathione S-transferases alpha and pi, and aldehyde dehydrogenase are associated with resistance to carboplatin and/or cyclophosphamide in cell lines. Therefore, we examined whether the expression of these factors in ovarian cancer tissue specimens is associated with resistance of the patients to combination chemotherapy with cyclophosphamide/carboplatin. Ovarian cancer tissue specimens were taken intraoperatively from 139 patients and frozen in liquid nitrogen, and the contents of glutathione S-transferases alpha and pi, total glutathione, and aldehyde dehydrogenase activity were determined. No association between the levels of glutathione S-transferases alpha and pi or alde…

Weighted Integration of Duration Information Across Visual and Auditory Modality Is Influenced by Modality-Specific Attention.

2021

We constantly integrate multiple types of information from different sensory modalities. Generally, such integration is influenced by the modality that we attend to. However, for duration perception, it has been shown that when duration information from visual and auditory modalities is integrated, the perceived duration of the visual stimulus leaned toward the duration of the auditory stimulus, irrespective of which modality was attended. In these studies, auditory dominance was assessed using visual and auditory stimuli with different durations whose timing of onset and offset would affect perception. In the present study, we aimed to investigate the effect of attention on duration integr…

Quantifying Intermodal Distraction by Emotion During Math Performance: An Electrophysiological Approach

2019

Emotionally engaging stimuli are powerful competitors for limited attention capacity. In the cognitive neuroscience laboratory, the presence of task-irrelevant emotionally arousing visual distractors prompts decreased performance and attenuated brain responses measured in concurrent visual tasks. The extent to which distraction effects occur across different sensory modalities is not yet established, however. Here, we examined the extent and time course of competition between a naturalistic distractor sound and a visual task stimulus, using dense-array electroencephalography (EEG) recordings from 20 college students. Steady-state visual evoked potentials (ssVEPs) were quantified from EEG, e…

Advances in detection and characterization of atherosclerosis using contrast agents targeting the macrophage

2006

With advances in imaging technology and our understanding of the role of inflammation in atherosclerosis, the macrophage appears to be an excellent target for imaging the progression of disease. In addition to imaging the macrophage with only 1 modality, contrast agents can be created that can be imaged with multiple modalities. This seems extremely attractive, as lesion morphology and characteristics can be determined with modalities that provide high picture resolution, such as CT or MRI, whereas macrophage quantity can be accurately determined through the creation of a radiolabeled contrast agent such as FDG via PET. Although this combination of imaging technologies may yield clinically …

Rektumkarzinom: Behandeln wir zu häufig neoadjuvant? Vorschläge zu einer selektiveren, MRT-basierten Indikation

2006

The present-day optimised surgery (concept of total mesorectal excision) with quality assurance by standardized pathologic examination, advances in radiotherapy and the possibilities of high-spatial-resolution MR imaging require reconsideration of pros and contras of neoadjuvant therapy and respective data. According to the resulting new proposal neoadjuvant long-course radiochemotherapy is indicated for patients with 1) fixed questionably R0 resectable tumors, 2) mobile tumors with the MRT finding of tumor involving the mesorectal fascia or 1 mm or less from it, 3) low rectal tumors extending below the levator origin and invading beyond the muscularis propria. If a high risk of local recur…

Treatment of cervicofacial actinomycosis: a report of 19 cases and review of literature

2013

Objectives: Actinomycosis is a chronic suppurative granulomatous infection caused by the Actinomyces genus. Orocervicofacial actinomycosis is the most common form of the disease, seen in up to 55% of cases. All forms of actinomycosis are treated with high doses of intravenous penicillin G over two to six weeks, followed by oral penicillin V. Large studies on cervicofacial actinomycosis are lacking. Therefore proper guidelines for treatment and treatment duration are difficult to establish. The aim of this study is to establish effective treatment and treatment duration for orocervicofacial actinomycosis. Study design: A Pubmed and Embase search was performed with the focus on treatment and …