Search results for "model."
showing 10 items of 23664 documents
The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment
2020
The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified because of its key role in the regulation of glycogen synthesis. However, it is now well-established that GSK-3 performs critical functions in many cellular processes, such as apoptosis, tumor growth, cell invasion, and metastasis. Aberrant GSK-3 activity has been associated with many human diseases, including cancer, highlighting its potential therapeutic relevance as a target for anticancer therapy. Recently, newly emerging data have demonstrated the pivotal role of GSK-3 in the anticancer immune response. In the last few years, many GSK-3 inhibitors have been developed, and some are currently being te…
Harnessing dendritic cells in cancer.
2011
Dendritic cells (DCs) are central to the initiation of tumor-specific immune responses. However, the tumor microenvironment generates immunosuppressive cells and soluble mediators that compromise DC functions and limit the success of DC-based therapies. Progress in understanding DC metabolism in cancer is uncovering novel therapeutic targets that could restore DC capacity to prime T cells and trigger effective anticancer responses. Accumulating evidence also indicates that conventional chemo- and radiotherapy protocols can cause DC activation, enhance antigen cross-presentation, selectively eliminate immunosuppressive cells and revert the immunosuppression state caused by cancer, suggesting…
C5a complement and cytokine signaling mediate the pronociceptive effects of complex regional pain syndrome patient IgM in fracture mice.
2020
It has been proposed that complex regional pain syndrome (CRPS) is a posttraumatic autoimmune disease. Previously, we observed that B cells contribute to CRPS-like changes in a mouse tibia fracture model, and that early (12 months duration) CRPS patient IgM antibodies have pronociceptive effects in the skin and spinal cord of muMT fracture mice lacking B cells. The current study evaluated the pronociceptive effects of intraplantar or intrathecal injections of early CRPS IgM (5 µg) in muMT fracture mice. Skin and lumbar spinal cord were collected for immunohistochemistry and polymerase chain reaction analyses. Wild-type mice exhibited postfracture increases in complement component C5a and it…
Efficacy of Computer-Aided Static Navigation Technique on the Accuracy of Endodontic Microsurgery. A Systematic Review and Meta-Analysis
2021
The aim of this systematic review and meta-analysis was to analyze the efficacy of the computer-aided static navigation technique on the accuracy of root apex location in endodontic microsurgery. Material and Methods: A systematic literature review and meta-analysis, based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, of clinical studies that evaluated the apex location rate of the computer-aided static navigation techniques applied to endodontic microsurgery. A total of four databases were consulted in the literature search: Pubmed-Medline, Scopus, Cochrane, and Web of Science. After eliminating duplicated articles and applying the inclusio…
Understanding the relationship between subjective health complaints and satisfaction with life for people in prevocational training in Norway
2021
Background and aim: In Norway, a large part of the population is dependent on disability benefits. The main reasons for this are related to long-term musculoskeletal pain and psychological complaints. Prevocational rehabilitation, aimed at increasing participation in working life, targets people in need of a sheltered vocational environment. This group has been found to report a very high level of health complaints. Therefore, a better understanding of the psychological mechanisms affecting satisfaction with life for people who experience subjective health complaints could be important for tailoring more optimal vocational rehabilitation initiatives for these individuals. This study aimed t…
Ķīnas sociālais kredīts kā sabiedrības kontroles instruments
2022
Bakalaura darba “Ķīnas sociālais kredīts kā sabiedrības kontroles instrumets” mērķis ir noteikt, kādus naratīvus saistībā ar sociālo kredītu sistēmu veido vadošie Ķīnas un Āzijas ziņu portāli angļu valodā un noskaidort, vai šajos medijos tie ir atšķirīgi, atsevišķi, analizējot autoritārā, atkarīgā un demokrātiskā, neatkarīgā medja iekļautos naratīvus. Kā papildus mērķis ir izvirzīts notiekt, kādā veidā Ķīna, izmantojot medijus, ir spējīga kontrolēt sabiedrību, tajā notiekošos procesus, pilnībā radot jaunu dzīves vidi. Darba teorētiskajā daļā aprakstīta Ķīnas sociālā kredīta būtība, naratīva teorija un naratoloģijas pielietojums, aprakstīts, kā masu mediji spēj būt sociālās kontroles instrum…
DEVELOPMENT AND MODELING OF MEMBRANE PROCESSES FOR THE REGENERATION OF ACID PICKLING SOLUTIONS
2021
The doctoral thesis focuses on a novel integrated process for the recovery and valorisation of acid and metal salts present in the waste solutions of the pickling process. The proposed process is based on the integration of two innovative membrane technologies, the Diffusion Dialysis and the Membrane Distillation, coupled with a reactive precipitation section. This hybrid process allows the recovery and the enhancement of waste solutions, as well as optimal operating conditions for the continuous pickling process, thus improving its efficiency. Hydrochloric acid recovery was assessed through a detailed study on the Diffusion Dialysis process by implementing a wide experimental campaign usin…
Characterisation of the Degree of Musical Non-Markovianity
2022
As an aid for musical analysis, in computational musicology mathematical andinformatics tools have been developed to characterise quantitatively some aspectsof musical compositions. A musical composition can be attributed by ear a certainamount of memory. These results are associated with repetitions and similarities ofthe patterns in musical scores. To higher variations, a lower amount of memory isperceived. However, the musical memory of a score has never been quantitativelydefined. Here we aim to give such a measure following an approach similar tothat used in physics to quantify the memory (non-Markovianity) of open quantumsystems. We apply this measure to some existing musical composit…
Asiantuntijat uusien toimintamallien oppijoina
2003
Työ muuttuu ja sitä kautta myös työssä tarvittavien toimintatapojen pitäisi muuttua. Ajattelumallien tai toimintatapojen muuttaminen ei ole aina helppoa, sillä käytössä olevat mallit rutinoituvat nopeasti. Ihmisillä ei ole kykyä, halua tai aikaa tarkastella omaa työtään uusien silmälasien läpi, arvioida tapojensa toimivuutta tai jopa kokonaan kyseenalaistaa niiden järkevyyttä. Mielenkiintoisen ratkaisun etsiä uusia toimintamalleja ennakkoluulottomasti edustaa seuraava esimerkki Englannista. – Artikkelissa kuvataan brittiläisessä sairaalassa toteutettua kehittämisprosessia, jossa lääkärien visuaalisen hahmottamisen apuna on käytetty taiteilijoita.