Search results for "model."
showing 10 items of 23664 documents
Variational parabolic capacity
2015
We establish a variational parabolic capacity in a context of degenerate parabolic equations of $p$-Laplace type, and show that this capacity is equivalent to the nonlinear parabolic capacity. As an application, we estimate the capacities of several explicit sets.
Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS.
2005
Phosphorylated p38 mitogen-activated protein kinase (p38MAPK), but not activated c-jun-N-terminal kinase (JNK), increases in the motor neurons of transgenic mice overexpressing ALS-linked SOD1 mutants at different stages of the disease. This effect is associated with a selective increase of phosphorylated MKK3-6, MKK4 and ASK1 and a concomitant upregulation of the TNFalpha receptors (TNFR1 and TNFR2), but not IL1beta and Fas receptors. Activation of both p38 MAPK and JNK occurs in the activated microglial cells of SOD1 mutant mice at the advanced stage of the disease; however, this effect is not accompanied by the concomitant activation of the upstream kinases ASK1 and MKK3,4,6, while both …
Apollon gene silencing induces apoptosis in breast cancer cells via p53 stabilisation and caspase-3 activation
2009
We analysed the effects of small interfering RNA (siRNA)-mediated silencing of Apollon, a member of the inhibitors of apoptosis protein family, on the proliferative potential and ability of human breast cancer cell lines to undergo apoptosis. In wild-type p53 ZR75.1 cells, Apollon knockdown resulted in a marked, time-dependent decline of cell growth and an increased rate of apoptosis, which was associated with p53 stabilisation and activation of the mitochondrial-dependent apoptotic pathway. Pre-incubation of cells with a p53-specific siRNA resulted in a partial rescue of cell growth inhibition, as well as in a marked reduction of the apoptotic response, indicating p53 as a major player in …
Measurement of the average shape of longitudinal profiles of cosmic-ray air showers at the Pierre Auger Observatory
2019
The profile of the longitudinal development of showers produced by ultra-high energy cosmic rays carries information related to the interaction properties of the primary particles with atmospheric nuclei. In this work, we present the first measurement of the average shower profile in traversed atmospheric depth at the Pierre Auger Observatory. The shapes of profiles are well reproduced by the Gaisser-Hillas parametrization within the range studied, for E>10 17.8 eV .A detailed analysis of the systematic uncertainties is performed using ten years of data and a full detector simulation. The average shape is quantified using two variables related to the width and asymmetry of the profile, and …
Estudio del efecto del paclitaxel en las propiedades físicas, biomecánicas y fisiológicas del tejido cutáneo en pacientes oncológicos y en cultivos d…
2020
La toxicidad en la piel es uno de los efectos perjudiciales más comunes de los taxanos. El objetivo fue evaluar el efecto del fármaco paclitaxel sobre la piel en un grupo de pacientes con cáncer ginecológico, y en un modelo 3D in vitro de piel, así como en melanocitos, queratinocitos, fibroblastos y en células microvasculares dérmicas humanas. En el estudio in vivo se realizaron las medidas en una población control de mujeres sanas (n=20) y una población de pacientes con tumores ginecológicos en tratamiento con paclitaxel (n=20), antes, durante y después. Las diferentes determinaciones fueron el valor de hidratación, la TEWL, el valor de sebo, valores de pigmentación y eritema, valores de e…
MALATTIA OSSEA DI PAGET
2010
NMDA receptor antagonists and pain relief: A meta-analysis of experimental trials
2019
ObjectiveWe conducted a meta-analysis of controlled trials that used experimental models of acute pain and hyperalgesia to examine the analgesic effects of NMDA receptor (NMDAR) antagonists.MethodsSix major databases were systematically searched (to March 2018) for studies using human evoked pain models to compare NMDAR antagonists with no-intervention controls. Pain outcome data were analyzed with random-effects meta-analysis.ResultsSearches identified 70 eligible trials (n = 1,069). Meta-analysis found that low-dose ketamine (<1 mg/kg) produced a decrease in hyperalgesic area (standardized mean difference 0.54, 95% confidence interval [CI] 0.34, 0.74, p < 0.001) and a 1.2-point decr…
Sperimentazione di una procedura per la creazione di un atlante digitale per la documentazione dei soffitti lignei dipinti di Sicilia
2021
The naves of churches and the halls of noble palaces. The paintings that decorate these ceilings are precious evidence of the wide cultural connections that linked Sicily to Europe and to the Mediterranean area. The paper reports the results of research aiming at the development of a workflow for the creation of a digital atlas of these ceilings. Digital representation overcomes one of the main obstacles to the study, the preservation and the dissemination of these works of art, i.e. the traditional dichotomy between photographic images and drawings. The chosen case study is the ceiling that covers the main hall of the Steri in Palermo, a 14th-century palace that today hosts the offices of …
The action of a compact Lie group on nilpotent Lie algebras of type {{n,2}}
2015
Abstract We classify finite-dimensional real nilpotent Lie algebras with 2-dimensional central commutator ideals admitting a Lie group of automorphisms isomorphic to SO 2 ( ℝ ) ${{\mathrm{SO}}_{2}(\mathbb{R})}$ . This is the first step to extend the class of nilpotent Lie algebras 𝔥 ${{\mathfrak{h}}}$ of type { n , 2 } ${\{n,2\}}$ to solvable Lie algebras in which 𝔥 ${{\mathfrak{h}}}$ has codimension one.
Measuring the gender wage gap : a methodological note
2020
We propose to estimate the Blinder-Oaxaca decomposition by a single-equation model augmented with interactions between the group membership and other predictors. The relative importance of predictors on the discriminatory wage gap is examined by the interaction coefficients, which may lead to very different conclusions than the usual percentage calculations using the detailed decomposition method. Comparisons are made between the traditional interpretations and those suggested here using wage data from Finland. The decomposition analysis suggests that the discriminatory male-female wage gap is largely related to work experience, while our preferred model points to the importance of family g…