Search results for "modeling"

Validation of an explicative model of the successful aging process with psychological, physical, relational, and leisure variables

2015

Increasingly, research on the aging process tends to adopt a dual perspective emic (specific to a culture) and etic (universal), requiring further studies to address this cross-cultural approach. The aim is to obtain an empirical answer to the question of whether a model of successful aging raised from a different context such as the Taiwanese context, is suitable to represent this process in our elders. The sample consisted of 737 elderly. Socio-demographic-data and different scales to assess life satisfaction, leisure, health, and social support were collected. A structural equation model taken from Lee et al. (2011), in which leisure, health and social support predicted life satisfaction…

Noninvasive Flap Preconditioning by Foam-Mediated External Suction Improves the Survival of Fasciocutaneous Axial-Pattern Flaps in a Type 2 Diabetic …

2018

Background Advances in reconstructive surgery are leading to an increased number of flaps at risk for ischemic necrosis, because of either intrinsic (e.g., larger flap size) or extrinsic (e.g., diabetes) factors. Methods to preoperatively improve flap vascularity and limit postoperative ischemia are lacking. Noninvasive suction, using either a macrodeformational silicone cup interface (external volume expansion) or a microdeformational polyurethane foam interface (foam-mediated external volume expansion), has been shown to induce angiogenesis in tissues. The authors investigated whether the preoperative use of external volume expansion/foam-mediated external volume expansion improves flap s…

In Silico Design, Synthesis and Biological Evaluation of Anticancer Arylsulfonamide Endowed with Anti-Telomerase Activity

2022

Telomerase, a reverse transcriptase enzyme involved in DNA synthesis, has a tangible role in tumor progression. Several studies have evidenced telomerase as a promising target for developing cancer therapeutics. The main reason is due to the overexpression of telomerase in cancer cells (85–90%) compared with normal cells where it is almost unexpressed. In this paper, we used a structure-based approach to design potential inhibitors of the telomerase active site. The MYSHAPE (Molecular dYnamics SHared PharmacophorE) approach and docking were used to screen an in-house library of 126 arylsulfonamide derivatives. Promising compounds were synthesized using classical and green methods. Com…

ANALYSIS OF SUNSPOT NUMBER FLUCTUATIONS

2004

Monthly averages of the sunspot number visible on the sun, observed from 1749, Zurich Observatory, and from 1848 other observatories, have been analyzed. This time signal presents a frequency power spectra with a clear 1/fα behavior with α≃0.8±0.2. The well-known cycle of approximately 11 years, clearly present in the spectrum, does not produce a sensible distortion of that behavior. The eventual characterization of the sunspot time series as a fractal is analyzed by means of the detrended fluctuation analysis (DFA). The jump-size distribution of the signal is also studied.

Modelling, Simulation and Characterization of a Supercapacitor in Automotive Applications

2020

The energy storage is one of the most discussed topics among Electrical Vehicles (EVs) research. Currently, supercapacitors (SCs) are collecting even more attention due to their unique features such as high-power density, high life cycle and lack of maintenance. In this paper, a supercapacitor model suitable for the simulation in automotive applications is identified. The model parameters are estimated and used to simulate the behaviour of a commercial SCs bank in different operating conditions. The model is finally validated considering experimental results.

Quantum Monte Carlo Simulations of Models Related to High-Tc Superconductivity on a Transputer Network

1991

Much of the insight into the low temperature behaviour of two-dimensional quantum antiferromagnets has been recently obtained by extensive Monte Carlo. These models are relevant in the study of the magnetic behaviour of high Tc compounds containing copper-oxide layers. While of little technical importance, the physical properties of these models are certainly important for the understanding of the new type of behaviour that leads to superconductivity under certain conditions.

Change in Newcomers' Supervisor Support and Socialization Outcomes After Organizational Entry

2009

Using a four-wave longitudinal research design and a latent growth modeling approach, we modeled change in newcomers' perceived supervisor support and socialization outcomes (role clarity, work mas...

NATURAL GAS SUPPLY CHAIN: A SYSTEM AND PERFORMANCE ORIENTED APPROACH

Global energy consumption has been increasing in recent years. Among the main global energy sources, natural gas stands out. It presents benefits from diverse points of view, low emissions for the environment, low price for the consumers, lower cost and simplicity in the supply. That is why, within the global policies of emission reduction, natural gas is considered the source of transition energy between fossil fuels and clean, renewable and sustainable sources of energy. Considering that natural gas is a non-renewable resource, it presents a significant and progressive reduction in reserves in some regions worldwide, but with ample possibilities for the discovery of new reserves and trans…

Fusing storage and computing for the domain of business intelligence and analytics: research opportunities

2015

With the growing importance of external and shared data, the set of requirements for Business Intelligence and Analytics (BIA) is shifting. Current solutions still come with shortcomings, esp. In multi-stakeholder environments where sensitive content is exchanged. We argue that a new level in the evolution of BIA can be unlocked by tearing down the barriers between storage and computing based on upcoming storage technologies. In particular, we propose a revitalization of ideas from object-oriented databases. We present results from a joint project that aimed at delineating design options for BIA solutions built upon this idea. The paper outlines the interplay of various architectural layers…

Capacity constrained supply chains: a simulation study

2008

This paper explores the relationship between constrained capacity and supply chain performance. Six capacity constraint levels are studied under different inventory policies and information sharing strategies. The results suggest that an increment of production capacity, used in industry as local approach to manage increasing incoming orders, does not necessarily imply an improvement in customer service. In presence of information distortions, the strategy of augmenting production capacity can lead to satisfy at a higher cost an over-estimated market demand. The collaborative practices provide bullwhip effect dampening and inventory stability, and increase the ability of the structure to av…