Search results for "models"
showing 10 items of 8211 documents
Are Toll-like receptors and decoy receptors involved in the immunopathogenesis of systemic lupus erythematosus and lupus-like syndromes?
2011
In this paper we focus our attention on the role of two families of receptors, Toll-like receptors (TLR) and decoy receptors (DcR) involved in the generation of systemic lupus erythematosus (SLE) and lupus-like syndromes in human and mouse models. To date, these molecules were described in several autoimmune disorders such as rheumatoid arthritis, antiphospholipids syndrome, bowel inflammation, and SLE. Here, we summarize the findings of recent investigations on TLR and DcR and their role in the immunopathogenesis of the SLE.
CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis
2019
Abstract Background and Aims: In immunosuppressed individuals Aspergillus (A.) fumigatus is a frequent cause of invasive pulmonary aspergillosis (IPA) which is highly associated with relevant morbidity and mortality. Moreover, it often occurs in patients suffering from leukocyte-adhesion deficiency type 1 (LAD1) which is triggered by a functional loss of CD18 in ß2 integrin receptors as these receptors consist of an alpha subunit (CD11a-CD11d) and CD18 as the common beta subunit. ß2 integrin receptors are differentially expressed by leukocytes, and are required for cell-cell interaction, transendothelial migration, uptake of opsonized pathogens, and cell signaling processes. Here, we asked …
Modelos de organización política de la UMMA en la historia del pensamiento islámico
2011
ResumenEn el presente artículo, se estudian los modelos más representativos de organización política de la comunidad islámica o Umma en la historia del pensamiento islámico. Como introducción al tema, se analiza el papel central que ocupa el concepto de Umma como eje vertebrador de las relaciones entre religión y política en el Islam. Posteriormente, se exponen las principales posiciones acerca del gobierno de la Umma, desde los tiempos del Profeta hasta la actualidad. Por último, se propone la necesidad de desarrollar una completa y sistemática teoría sobre el modelo de organización política más acorde con una concepción democrática de la Umma.Abstract In this work the most representative …
Finnish Secondary Students’ Mental Models of Magnetism
2020
We examined Finnish lower secondary students’ mental models of magnetism through their drawings, written explanations and interviews. Secondary students in Finland (N=12) engaged in six lessons designed specifically to target three key concepts in understanding magnetism: structure and organization (magnetic domains), magnetic fields and magnetic interactions. We describe how, with a finite number of key concepts introduced, students reflected upon and revised their mental models of magnetism and magnetic interactions towards more sophisticated and normative scientific views. We found two new categories of students’ models: the pole model and pole/field model. The critical moments in evolvi…
Models de traducció literària i audiovisual en català col·loquial: el cas de «Jackie Brown» de Quentin Tarantino
2015
Aquest article tracta dels models de traducció col·loquial cap al català en el cas de la versió doblada (1997), la versió subtitulada (1997) i el guió traduït (1998) de Jackie Brown (1997) de Quentin Tarantino. El nucli de l’article és l’anàlisi i la comparació de la fonètica, la morfologia, la sintaxi i el lèxic de cada traducció catalana, que s’emmarca en els models lingüístics i de traducció vigents en el període objecte d’estudi. La conclusió a la qual s’arriba és que les tres traduccions utilitzen models de llengua col·loquial diferents. El guió traduït basteix un model trencador, sobretot en qüestions de representació fonètica i en el lèxic castellà que utilitza. La versió doblada s’a…
Evolucionismo, integración sociocognitiva y cambio semántico
2014
El cambio es el fenómeno lingüístico por excelencia a la hora de aplicar los modelos teóricos evolucionistas. La perspectiva evolucionista del lenguaje permite analizar el cambio lingüístico como un fenómeno sujeto a los mismos procesos evolutivos que determinan cualquier sistema evolutivo complejo. El objetivo de este estudio es defender una integración más sistemática de los factores sociales y cognitivos del cambio lingüístico, en particular del cambio semántico. Este artículo se centra en un enfoque evolutivo del cambio lingüístico muy influyente, la Teoría de la Selección del Enunciado del cambio lingüístico desarrollada por Croft (2000). El enfoque evolutivo de Croft se inspira en la …
Cap a una cronologia dels models teatrals de Pedrolo
2015
This article scans Pedrolo's dramatic oeuvre starting from the comparative analysis of story-line and thematic aspects, characters, space and time. The final ambition is to emphasize the fact that three periods may be defined: early theatrical experiments (1954-1956), central production (1957-1963) and the last plays (1966-1977), that respond to different theatrical models.
Assessment of nonnegative matrix factorization algorithms for electroencephalography spectral analysis.
2020
AbstractBackgroundNonnegative matrix factorization (NMF) has been successfully used for electroencephalography (EEG) spectral analysis. Since NMF was proposed in the 1990s, many adaptive algorithms have been developed. However, the performance of their use in EEG data analysis has not been fully compared. Here, we provide a comparison of four NMF algorithms in terms of accuracy of estimation, stability (repeatability of the results) and time complexity of algorithms with simulated data. In the practical application of NMF algorithms, stability plays an important role, which was an emphasis in the comparison. A Hierarchical clustering algorithm was implemented to evaluate the stability of NM…
Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of Atrip-Seckel syndrome
2020
ABSTRACT Seckel syndrome is a type of microcephalic primordial dwarfism (MPD) that is characterized by growth retardation and neurodevelopmental defects, including reports of retinopathy. Mutations in key mediators of the replication stress response, the mutually dependent partners ATR and ATRIP, are among the known causes of Seckel syndrome. However, it remains unclear how their deficiency disrupts the development and function of the central nervous system (CNS). Here, we investigated the cellular and molecular consequences of ATRIP deficiency in different cell populations of the developing murine neural retina. We discovered that conditional inactivation of Atrip in photoreceptor neurons …
Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model
2015
ABSTRACT Muscle mass wasting is one of the most debilitating symptoms of myotonic dystrophy type 1 (DM1) disease, ultimately leading to immobility, respiratory defects, dysarthria, dysphagia and death in advanced stages of the disease. In order to study the molecular mechanisms leading to the degenerative loss of adult muscle tissue in DM1, we generated an inducible Drosophila model of expanded CTG trinucleotide repeat toxicity that resembles an adult-onset form of the disease. Heat-shock induced expression of 480 CUG repeats in adult flies resulted in a reduction in the area of the indirect flight muscles. In these model flies, reduction of muscle area was concomitant with increased apopto…