Search results for "modification"

Evaluation of 2,3-epoxypropyl groups and functionalization yield in glycidyl methacrylate monoliths using gas chromatography

2014

Abstract Poly(glycidyl methacrylate- co -ethylene dimethacrylate) (poly(GMA- co -EDMA)) is most frequently used as parent monolith to obtain stationary phases with a variety of surface chemistries for liquid chromatography and capillary electrochromatography. Functionalization is performed by opening the accessible 2,3-epoxypropyl groups of the monolith with a suitable reagent. The number of 2,3-epoxypropyl groups which are accessible before and after the functionalization reaction, and the grafting yield, are important parameters, required both to optimize functionalization and to interpret the chromatographic performance of functionalized monoliths. In this work, a method capable of provi…

Heterobimetallic single-source precursors for MOCVD. Synthesis and characterization of volatile mixed ligand complexes of lanthanides, barium and mag…

1999

Several heterobimetallic complexes of general formula [(M 1 Q) m M 2 (dik) n ], where (M 1 Q) is Cu(salen) or Ni(salen) and M 2 (dik) n is a lanthanide tris(β-diketonate) or an alkali-earth element bis(β-diketonate) with more or less fluorinated diketonato(-) ligands, have been prepared and structurally characterized. Some of them were submitted to thermal and mass spectrometry analyses, and to isothermal vacuum sublimation tests, in view of their potential use as MOCVD single-source precursors for the deposition of heterobimetallic materials. The study stresses upon the influence of the nature of the diketone. of the M 2 cation, and of chemical modification of the salen ligand on the therm…

The EPPS16 nuclear PDFs

2017

We report on EPPS16 - the first analysis of NLO nuclear PDFs where LHC p-Pb data (Z, W, dijets) have been directly used as a constraint. In comparison to our previous fit EPS09, also data from neutrino-nucleus deeply-inelastic scattering and pion-nucleus Drell-Yan process are now included. Much of the theory framework has also been updated from EPS09, including a consistent treatment of heavy quarks in deeply-inelastic scattering. However, the most notable change is that we no longer assume flavour-blind nuclear modifications for valence and sea quarks. This significantly reduces the theoretical bias. All the analysed data are well reproduced and the analysis thereby supports the validity o…

Microfibrillar polymeric ocular inserts for triamcinolone acetonide delivery.

2019

Abstract Despite eye drops generally represent the most convenient, simple and patient-friendly formulations to treat ocular diseases, they suffer from poor retention on the ocular surface and low drug bioavailability leading to the necessity of prolonged and continuous treatment over time. Therefore, ocular insert could represent an innovative way to benefit from ocular topical administration while minimizing all the relevant limitation related to this route of administration. Polymeric non-erodible mucoadhesive ocular inserts should be comfortable and should rapidly adhere on the ocular surface, remain in situ for prolonged period, assure a reproducible and controlled drug release as well…

Pectin as Drug-Release Vehicle

2020

Pectin as a natural biopolymer is extensively used for pharmaceutical and biomedical applications, essentially due to its gelling properties that could be influenced by pectin sources and extraction methods. This chapter focuses on an overview of pectin drug delivery systems classified by their administration routes. Oral drug delivery systems have been mainly developed, as pectin could be used in tablets as binder or matrix excipients and in microparticles/beads obtained by ionotropic gelation. The main objective is to target the colon, as pectin is resistant in acidic pH and sensitive to pectinolytic enzymes in the colon. To obtain suitable properties, pectin could be used in its native s…

Asphalt mixtures improved with plastic additives: mix design and case study in an airport

La crescente domanda di prestazioni e le esigenze di salvaguardia dell’ecosistema spingono a sviluppare nuove tecnologie di lavorazione, a sperimentare l’impiego di nuovi materiali, a migliorare i metodi di progetto delle miscele. Il criterio seguito è quello di un impiego più razionale delle risorse e dell’utilizzo di tecniche a basso impatto ambientale. Per ragioni tecniche ed economiche stiamo assistendo al fenomeno di espansione nel mercato degli additivi, impiegati nella produzione di miscele bituminose per migliorarne le prestazioni e ridurre i costi. In generale, però riuscire a soddisfare tutti gli obiettivi con un unico prodotto è difficile, perché l’alta qualità richiede costi più…

Long-term analysis (1863–2002) of environmental change in the Capo Feto area (Mediterranean sea)

2004

The area of Capo Feto represents one of the few remaining salt-marshy zones in Sicily. It lies within a site of importance for the Community (defined as a “sito di importanza comunitaria” (SIC)), which also includes Margi Spanò and Margi Milo. The Capo Feto and Margi Spanò marshlands have also been identified by the Ministry for the Environment as an area deserving special protection (“zona a protezione speciale” (ZPS)). Moreover, in 1999, 150 ha of the Capo Feto area were included in a project for environmental rehabilitation as part of the European Union “Life-Nature 2000” programme (Comitato Tecnico-Scientifico Area di Capo Feto, 1997). Prior to this, the area had become somewhat degrade…

Defamilisation, Dedomestication and Care Policy: Comparing Childcare Service Provisions of Welfare States

2011

PurposeThis paper aims to use perspectives from both mainstream and feminist welfare state research in drafting a conceptual approach for social care research. This approach is then applied empirically to a comparative analysis of childcare provisions of 15 OECD countries.Design/methodology/approachThe concept of dedomestication is developed from a discussion on the notions of decommodification and defamilisation, and it is defined as the degree to which social care policies make it possible for people to participate in society and social life outside their homes and families. In the empirical part of the paper, dedomestication of childcare service provisions of 15 welfare states is measure…

Global trends in higher education: an unexpected convergence between France and India

2013

International audience; We propose to examine an unexpected convergence between the higher education systems of two heterogeneous countries, namely France and India. After a brief comparative survey, we address the issue of the commodification of higher education in order to determine whether the latter evolution has been acknowledged, encouraged or opposed by governments. The modern setting in which higher education institutions operate is partly determined by GATS rules that govern international trade in higher education services, notably through the enhancement of new modes of delivery such as e-learning and distance education. We then extend our reflection to bridge the gap between Fran…

Constitutive Promoter Occupancy by the MBF-1 Activator and Chromatin Modification of the Developmental Regulated Sea Urchin α-H2A Histone Gene

2007

The tandemly repeated sea urchin alpha-histone genes are developmentally regulated. These genes are transcribed up to the early blastula stage and permanently silenced as the embryos approach gastrulation. As previously described, expression of the alpha-H2A gene depends on the binding of the MBF-1 activator to the 5' enhancer, while down-regulation relies on the functional interaction between the 3' sns 5 insulator and the GA repeats located upstream of the enhancer. As persistent MBF-1 binding and enhancer activity are detected in gastrula embryos, we have studied the molecular mechanisms that prevent the bound MBF-1 from trans-activating the H2A promoter at this stage of development. Her…