Search results for "modification"

Local culture in the context of international tourism : Japanese tourists' perceptions of the culture of Saariselkä and the views of Japanese travel …

2012

In tourism, cultures are often used as resources to attract tourists. This is because tourism is generated by difference. So that the culture of a tourist destination can be consumed by tourists the culture needs to go through commodification, a process through which part of the culture turns into a product or a service. Knowing how a culture is used for tourism practice is important from the viewpoint of the cultural sustainability of tourism. The present study primarily aims at examining how the local culture is dealt with by the Japanese in Saariselkä through tourism. The study concentrates on how Japanese tourists perceive the local culture during their stay and how the Japanese travel …

Functionalization of nanoparticles in specific targeting and mechanism release

2017

The development of various nanotechnologies have provided a new field of research, which allows the manipulation of molecular components of matter and covers a vast array of nanodevices. The “smart” multifunctional nanostructures should work as customizable, targeted drug-delivery vehicles capable of carrying large doses of therapeutic agents into malignant cells. Some nanomedical approaches are based on the use of functionalized nanoparticles (NPs), not only to reduce toxicity and side effects of drugs but, also in potential the biological barriers crossing on, such as: the blood–brain barrier, different cellular compartments, including the nucleus. Currently, many materials are used for n…

La modification de l’expression génétique de la descendance de l’homme

2014

National audience

Commodification of higher education? : an analysis of Education and Training Sector Improvement Programme (ETSIP) phase 1 (2006 to 2011) document of …

2017

The conceptualization of education is an essential term which generally tends to be understood in different ways, this is especially in terms of how it is supposed to function in the society. For Namibia, the notion of education in Namibia is emphasised as an important sector to enable the country to achieve developmental goals. This is partly because of the education perspective(s) that has shaped how the concept of education is theoretically and practically understood from legislative framework to policy discourse. Additionally, the Higher Education (HE) sector plays contributes immensely on the development that the country strives to achieve yet the sector has been faced with various pro…

Effect of emotional picture viewing on classical eyeblink conditioning

2004

The role of elongational flow in morphology modification of Polyethylene/OMMT nanocomposite system

2011

The Epigenetics of the Endocannabinoid System

2020

The endocannabinoid system (ES) is a cell-signalling system widely distributed in biological tissues that includes endogenous ligands, receptors, and biosynthetic and hydrolysing machineries. The impairment of the ES has been associated to several pathological conditions like behavioural, neurological, or metabolic disorders and infertility, suggesting that the modulation of this system may be critical for the maintenance of health status and disease treatment. Lifestyle and environmental factors can exert long-term effects on gene expression without any change in the nucleotide sequence of DNA, affecting health maintenance and influencing both disease load and resistance. This potentially …

Carbohydrate-Based Nanocarriers Exhibiting Specific Cell Targeting with Minimum Influence from the Protein Corona.

2015

Whenever nanoparticles encounter biological fluids like blood, proteins adsorb on their surface and form a so-called protein corona. Although its importance is widely accepted, information on the influence of surface functionalization of nanocarriers on the protein corona is still sparse, especially concerning how the functionalization of PEGylated nanocarriers with targeting agents will affect protein corona formation and how the protein corona may in turn influence the targeting effect. Herein, hydroxyethyl starch nanocarriers (HES-NCs) were prepared, PEGylated, and modified on the outer PEG layer with mannose to target dendritic cells (DCs). Their interaction with human plasma was then s…

Characterization of the epigenetic modifications in human uterine leiomyomas and evaluation of their potential as therapeutic targets in vitro

2023

Los miomas o fibromas uterinos (UL) son los tumores benignos más frecuentes en las mujeres en edad reproductiva. A pesar de su elevada prevalencia y de las diferentes opciones de tratamiento, no existe terapia eficaz para la reducción del tamaño de los UL que sea mínimamente invasiva y sin efectos secundarios a largo plazo. Su patología tumoral permanece desconocida, lo que dificulta el desarrollo de tratamientos seguros y eficaces. Por lo tanto, la identificación de los mecanismos moleculares implicados en la generación de UL podría permitir el desarrollo de tratamientos más eficaces. Las modificaciones epigenéticas están implicadas en el desarrollo de los tumores y pueden revertirse media…

Estimates for the Differences of Certain Positive Linear Operators

2020

The present paper deals with estimates for differences of certain positive linear operators defined on bounded or unbounded intervals. Our approach involves Baskakov type operators, the kth order Kantorovich modification of the Baskakov operators, the discrete operators associated with Baskakov operators, Meyer&ndash