Search results for "motor"

showing 10 items of 3137 documents

Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons

2011

Transport of mRNAs to diverse neuronal locations via RNA granules serves an important function in regulating protein synthesis within restricted sub-cellular domains. We recently detected the Huntington's disease protein huntingtin (Htt) in dendritic RNA granules; however, the functional significance of this localization is not known. Here we report that Htt and the huntingtin-associated protein 1 (HAP1) are co-localized with the microtubule motor proteins, the KIF5A kinesin and dynein, during dendritic transport of β-actin mRNA. Live cell imaging demonstrated that β-actin mRNA is associated with Htt, HAP1, and dynein intermediate chain in cultured neurons. Reduction in the levels of Htt, H…

congenital hereditary and neonatal diseases and abnormalitiesHuntingtinDyneinModels NeurologicalBiological Transport ActiveKinesinsRNA-binding proteinNerve Tissue Proteinsmacromolecular substancesBiologyCytoplasmic GranulesMicrotubulesArticle03 medical and health sciences0302 clinical medicineMicrotubulemental disordersProtein biosynthesisMRNA transportAnimalsRNA MessengerRNA Small InterferingRats WistarCells Cultured030304 developmental biologyNeurons0303 health sciencesHuntingtin ProteinMultidisciplinaryMolecular Motor ProteinsBrainDyneinsNuclear ProteinsRNA-Binding ProteinsDendritesActinsCell biologynervous system diseasesRatsDendritic transportnervous systemGene Knockdown TechniquesKinesinFemale030217 neurology & neurosurgerySignal TransductionScientific Reports
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Anticipatory postural adjustments during joint action coordination

2019

International audience; There is a current claim that humans are able to effortlessly detect others’ hidden mental state by simply observing their movements and transforming the visual input into motor knowledge to predict behaviour. Using a classical paradigm quantifying motor predictions, we tested the role of vision feedback during a reach and load-lifting task performed either alone or with the help of a partner. Wrist flexor and extensor muscle activities were recorded on the supporting hand. Early muscle changes preventing limb instabilities when participants performed the task by themselves revealed the contribution of the visual input in postural anticipation. When the partner perfo…

coordinationPosturelcsh:MedicineActivationSocio-culturaleReaching MovementsArticleTimesocial behaviorCorticesMedical researchextensor muscleMotor controlLS5_1[SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]Posture coordination extensor muscle flexor muscle social behaviorlcsh:Scienceflexor muscleSupplementary Motor Arealcsh:RHandAcquisitionPremotorlcsh:QPerception[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]Load-Lifting Task[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
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Reproducibility of Rolandic beta rhythm modulation in MEG and EEG

2022

The Rolandic beta rhythm, at ∼20 Hz, is generated in the somatosensory and motor cortices and is modulated by motor activity and sensory stimuli, causing a short lasting suppression that is followed by a rebound of the beta rhythm. The rebound reflects inhibitory changes in the primary sensorimotor (SMI) cortex, and thus it has been used as a biomarker to follow the recovery of patients with acute stroke. The longitudinal stability of beta rhythm modulation is a prerequisite for its use in long-term follow-ups. We quantified the reproducibility of beta rhythm modulation in healthy subjects in a 1-year-longitudinal study both for MEG and EEG at T0, 1 month (T1-month, n = 8) and 1 year (T1-ye…

cortical oscillationevent-related synchronizationMEGliikeaistineurofysiologiabiomarkkeritpassive movementEEGcutaneous stimulusmotoriikkaevent-related desynchronization
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Cortical gene expression in spinal cord injury and repair: insight into the functional complexity of the neural regeneration program

2011

Traumatic spinal cord injury (SCI) results in the formation of a fibrous scar acting as a growth barrier for regenerating axons at the lesion site. We have previously shown (Klapka et al., 2005) that transient suppression of the inhibitory lesion scar in rat spinal cord leads to long distance axon regeneration, retrograde rescue of axotomized cortical motoneurons, and improvement of locomotor function. Here we applied a systemic approach to investigate for the first time specific and dynamic alterations in the cortical gene expression profile following both thoracic SCI and regeneration-promoting anti-scarring treatment (AST). In order to monitor cortical gene expression we carried out micr…

corticospinal tractmedicine.medical_treatmentlesion scarlcsh:RC321-571Cellular and Molecular Neuroscienceanti-scarring treatmentmedicineAxonlcsh:Neurosciences. Biological psychiatry. Neuropsychiatrysensorimotor cortexMolecular BiologySpinal cord injurySpinal Cord RegenerationOriginal Researchbusiness.industryRegeneration (biology)axonal regenerationmedicine.diseaseSpinal cordspinal cord injuryaxotomymedicine.anatomical_structureCorticospinal tractAxotomybusinessmicroarrayNeural developmentNeuroscienceNeuroscienceFrontiers in Molecular Neuroscience
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Prassi di chirurgia della coxa manus

2013

coxa manusSettore MED/33 - Malattie Apparato Locomotore
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The Effect of the Cranial Electrotherapy on the Muscle Motor Function in Different Operating Modes

2015

The aim of the present study was to analyze the effect of cranial electrotherapy stimulation on muscle function analysis indicators. Instrumental assessment of muscle function (on a REV9000, Technogym, Italy) was performed before and after cranial electrotherapy stimulation, assessments of the muscle function was performed during knee extension maximum voluntary, isometric contraction (MVIC), angle velocity with load 45Nm isotonic contraction and maximum pick torque in isokinetic contraction on 30°/s, 200°/s and 300°/s and neuromuscular efficiency measurements. To analyze data was used Excel program Statistics 3.1. Subjects of our study were twenty healthy athletes of sport fitness. 1 minu…

cranial electrical stimulation; dynamometer; electromyogram; isokinetic; isometric; isotonicIsokinetic contractionmedicine.medical_specialtyCranial electrotherapy stimulationCranial Electrical Stimulationbusiness.industrymedicine.medical_treatmentIsometric exerciseKnee extensionMotor functionPhysical medicine and rehabilitationElectrotherapyIsotonicPhysical therapyMedicinebusinessSOCIETY, INTEGRATION, EDUCATION. Proceedings of the International Scientific Conference
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Primary school teachers' and P.E. teachers' accuracy in assessing children's gross motor performance

1998

criterion-referenced testdevelopmental coordination disordermotor developmentmotor assessment
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Rokas sagatavošana rakstīšanai 5 - 6 gadus veciem bērniem ar jauktiem attīstības traucējumiem

2019

Diplomdarba temats: Rokas sagatavošana rakstīšanai 5 – 6 gadus veciem bērniem ar jauktiem attīstības traucējumiem. Darba autore: Laura Priede - Rozentāle Darba vadītāja: Egija Laganovska Darba apjoms: 46 lpp., 17 attēli, 7 tabulas, 3 pielikumi, 44 bibliogrāfiskie nosaukumi. Darbs izstrādāts ar mērķi teorētiski pētīt un empīriski pamatot dabas materiālu izmantošanas iespējas rokas sagatavošanā rakstīšanai 5 – 6 gadus veciem bērniem ar jauktiem attīstības traucējumiem. Darbā teorētiski pētīta pedagoģiskā un psiholoģiskā literatūra par dabas materiālu izmantošanas iespējām rokas sagatavošanā rakstīšanai 5 – 6 gadus veciem bērniem ar jauktiem attīstības traucējumiem, tai skaitā analizētas bērnu…

dabas materiālu izmantošanabērniPedagoģijaar jauktiem attīstības traucējumiemsīkā motorika
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Dabas materiālu izmantošana sīkās motorikas attīstībā 2-3 gadus veciem bērniem

2021

Kvalifikācijas darba tēma ir ‘’Dabas materiālu izmantošana sīkās motorikas attīstībā 2-3 gadus veciem bērniem’’. Mērķis ir teorētiski un praktiski izpētī dabas materiālu ietekmi uz sīkās motorikas attīstību. Darbs sastāv no trīs daļām. Pirmajā daļā ir teorētiski apkopots par sīkās motorikas attīstību. Otrajā nodaļā aprakstīts kā dabas materiālus ieviest mācību vidē un cik daudz tie tiek izmantoti rotaļās. Kā arī, kā dabas materiāli palīdz attīstīt sīko motoriku. Trešajā daļā tiek apkopots praktiskais pētījums, kurā galvenā pētījuma metode ir novērošana un aptaujas analizēšana. Rezultātā tiek paplašinātas zināšanas kā veicināt un uzlabot bērnu sīkās motorikas attīstību ar dabas materiālu pal…

dabas zinību centrsPedagoģijasīkās motorikas attīstībadabas materiālisīkā motorika
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Vecāka pirmsskolas vecuma bērnu rakstītprasmes veicināšana rotaļās un spēles

2018

Bakalaura darba temats: „Vecākā pirmsskolas vecuma bērnu rakstītprasmes veicināšana rotaļās un spēlēs”. Darba autors: Irīna Sorokuna Darbs izstrādāts ar mērķi: teorētiski izzināt un empīriski pamatot vecākā pirmsskolas vecuma bērnu rakstītprasmes veicināšanas iespējas spēlēs un rotaļās. Darba teorētiskajā daļā raksturots 5 – 6 gadus vecu bērnu psihofiziskā attīstība, nosakot priekšnoteikumus rakstītprasmes apguvei. Tiek analizēts rakstītprasmes jēdziens, struktūra, nosakot tās prasmes, kas bērnam ir jāapgūst, lai iemācītos rakstīt, vienlaicīgi tiek uzsvērtas arī attīstības jomas, tai skaitā motoriskā (grafisko iemaņu apguve), motivācijas un kognitīvā (psihisko procesu atbilstošs attīstības …

didaktiskās spēlesSkolas pedagoģijarakstītprasmevecākais pirmsskolas vecumsrotaļassīkā motorika
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