Search results for "mrm"
showing 6 items of 6 documents
Antiepileptogenic Effect of Subchronic Palmitoylethanolamide Treatment in a Mouse Model of Acute Epilepsy
2018
Research on the antiepileptic effects of (endo-)cannabinoids has remarkably progressed in the years following the discovery of fundamental role of the endocannabinoid (eCB) system in controlling neural excitability. Moreover, an increasing number of well-documented cases of epilepsy patients exhibiting multi-drug resistance report beneficial effects of cannabis use. Pre-clinical and clinical research has increasingly focused on the antiepileptic effectiveness of exogenous administration of cannabinoids and/or pharmacologically induced increase of eCBs such as anandamide (also known as arachidonoylethanolamide [AEA]). Concomitant research has uncovered the contribution of neuroinflammatory p…
In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats
2019
Graphical abstract
Lipidomic profiling identifies signatures of metabolic risk
2020
Background: Metabolic syndrome (MetS), the clustering of metabolic risk factors, is associated with cardiovascular disease risk. We sought to determine if dysregulation of the lipidome may contribute to metabolic risk factors. Methods: We measured 154 circulating lipid species in 658 participants from the Framingham Heart Study (FHS) using liquid chromatography-tandem mass spectrometry and tested for associations with obesity, dysglycemia, and dyslipidemia. Independent external validation was sought in three independent cohorts. Follow-up data from the FHS were used to test for lipid metabolites associated with longitudinal changes in metabolic risk factors. Results: Thirty-nine lipids were…
Detección de nuevos marcadores asociados a daño por reperfusión y fibrosis en infarto de miocardio validados histopatológicamente mediante análisis m…
2022
La resonancia magnética cardiovascular (RMC) con realce tardío es la técnica de referencia para la evaluación no invasiva del daño cardíaco después de un infarto de miocardio (IM). Sin embargo, la interpretación de estas imágenes en términos de daño tisular es aún complicado y el uso de agentes de contraste en esta técnica está contraindicado en un amplio sector de la población con insuficiencia renal crónica. La microscopía de resonancia magnética (MRM) proporciona un nivel de detalle comparable al objetivo macroscópico de la microscopía óptica. Por ello, podría ser una herramienta muy útil en la interpretación de la imagen de RMC y en la identificación de nuevos marcadores de imagen de re…
An Endemic Plant of the Mediterranean Area: Phytochemical Characterization of Strawberry Tree (Arbutus unedo L.) Fruits Extracts at Different Ripenin…
2022
This work focused on the extraction, quantification, and characterization of bioactive compounds of Arbutus unedo L. fruits, comparing the results obtained from the different ripening states. Extractions were performed by different methods (such as maceration extraction and ultrasonic extraction) and food grade solvents (aqueous and hydroalcoholic solvents) in each of the all ripening states (four states considered, associated with four different colors, i.e., green, yellow, orange, and red). The presence of (poly)phenols was quantified and characterized, and scavenging activity was determined by the Folin–Ciocâlteu reagent and the DPPH method, respectively. The content of bioactive compoun…
Latvijas zemes izmantošanas un zemes izmantošanas maiņas matricas izveidošana, izmantojot meža resursu monitoringa ģeotelpisko informāciju
2020
Zemes izmantošanas un zemes izmantošanas maiņas aprēķina matrica ir viena no svarīgākajām valsts siltumnīcefekta gāzu (SEG) inventarizācijas sastāvdaļām zemes izmantošanas, zemes izmantošanas maiņas un mežsaimniecības (ZIZIMM) sektorā, kas sniedz kopsavilkumu par izmaiņām zemes izmantošanā valstī kopš 1990. gada. Informāciju par zemes izmantošanu un zemes izmantošanas maiņu izmanto, lai aprēķinātu pārējos parametrus, kuri ir svarīgi SEG emisiju un oglekļa krājumu izmaiņu noteikšanai dzīvajā un nedzīvajā biomasā, augsnē un zemsegā, kā arī tā sniedz informāciju par pielietoto klimata pārmaiņu mazināšanas pasākumu ietekmi uz SEG emisijām. Zemes izmantošanas maiņas aprēķinus var veikt daļēji au…