Search results for "multifocal"

Assessing the in vitro optical quality of presbyopic solutions based on the axial modulation transfer function.

2016

Purpose To present a metric for assessing the in vitro optical quality of rotationally symmetrical optical elements based on volume calculation under the surface defined by the axial modulation transfer function (MTF). Setting University of Valencia, Valencia, Spain. Design Experimental study. Methods The metric volume under the axial MTF was used to assess the optical quality of 2 rotationally symmetrical multifocal intraocular lenses (IOLs) within various defocus intervals (0.50 diopter [D], 0.75 D, and 1.00 D) and at various spatial frequency intervals (7.5 cycles per degree [cpd], 15.0 cpd, and 30.0 cpd). Results The far focus of the bifocal IOL yielded higher volume values at all spati…

Correlation between optics quality of multifocal intraocular lenses and visual acuity

2009

Purpose To study the relationship between the optics quality of multifocal intraocular lenses (IOLs) and distance-corrected near, intermediate, and distance visual acuity to determine the degree to which optics quality must change to produce a significant difference in visual acuity. Setting Fundacion Oftalmologica del Mediterraneo, Valencia, Spain. Methods Monocular distance-corrected visual acuity (decimal and logMAR) was measured at 4 m, 70 cm, and 30 cm under photopic and mesopic conditions in eyes with 1 of 3 multifocal IOL models. Visual acuity versus the “average modulation” of the IOL was assessed. Results The pupil diameter and patient age were similar between the 3 IOL groups (20 …

THREE-DIMENSIONAL INTEGRAL MICROSCOPY WITH ENHANCED RESOLUTION AND DEPTH OF FIELD

2016

In this contribution we explain two new techniques developed by our group, which permit to increase the two-dimensional spatial resolution of the computed depth images in integral microscopy.

Characteristic morphologic manifestation of CADASIL, cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy, in s…

1997

Four cases of progressive multifocal leukoencephalopathy in iatrogenic immunocompromised patients

2020

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS) caused by John Cunningham Virus (JCV). We report four PML cases in immunocompromised patients, respectively treated with (1) Natalizumab, (2) Rituximab, (3) autologous stem-cell transplantation, and (4) Tacrolimus. All patients underwent neurological examination, magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), JCV-DNA research on biological samples, and lymphocytes subpopulation study. All cases presented with motor, behavioural, and cognitive disorders. Visual, sensitive, and cerebellar deficits developed in three cases. MRI revealed widespread progressiv…

Through-focus response of multifocal intraocular lenses evaluated with a spatial light modulator

2012

A new testing technique based on the use of a liquid crystal spatial light modulator (SLM) is proposed to analyze the optical quality of multifocal intraocular lenses (MIOLs). Different vergences and decentrations of the incident beam can be programmed onto the SLM in order to record the point spread function (PSF) for different object positions. From these axial PSFs, the through-focus modulation transfer function is computed. Because there are no moving parts in the experimental setup, this method is fast and versatile to assess MIOLs. Experimental results confirm the potential of the proposed method.

Evaluation of the performance of multifocal intraocular lenses image quality: analysis of the standard methods

2007

Purpose: To analyze the standard methods used to describe intraocular lenses (IOL) and to suggest some improvements to make them applicable for multifocal IOLs. Methods: The EN-ISO standards and the standards of the American National Standards Institute (ANSI) for the evaluation of the performance of IOLs are tested for multifocal IOLs. The MTF of the one refractive multifocal IOL and two hybrid refractive-diffractive multifocal IOLs is measured for both distance focus and near focus and using different pupil sizes. Results: The average modulation (AM) from 0 to 100 c/mm of multifocal IOLs (for the distance focus) is about 40-50% lower than the AM of monofocal IOLs, for all pupil sizes stud…

Diffractive multifocal intraocular lenses: reading performance and quality of life evaluation

2011

ABSTRACT Purpose: To evaluate the reading performance and changes in quality of life after cataract surgery with multifocal diffractive (IOLs) implantation Setting: Section of Ophthalmology - Department of Experimental Biomedicine and Clinical Neuroscience, University of Palermo, Italy; Eye Clinic - Department of Preclinical and Clinical Pharmacology, University of Florence, Italy. Methods: 160 Consecutive eyes of cataract patients were divided into two groups. One group (20 patients, 40 eyes) received aspheric monofocal IOLs (Acrysof SN60WF). One group (60 patients, 120 eyes) was implanted with a diffractive aspheric multifocal IOL produced by different manufacturers: 20 patients with Acry…

Contrast sensitivity after refractive lens exchange with diffractive multifocal intraocular lens implantation in hyperopic eyes

2008

Contrast Test chart at distance and near under 3 luminance levels (85.0 cd/m 2 , 5.0 cd/m 2 , and 2.5 cd/m 2 ) before and after RLE with bilateral AcrySof ReSTOR IOL implantation in 30 hyperopic eyes with presbyopia and low astigmatism (%1.0 diopter). Results after surgery were compared with those before surgery. RESULTS: Six months postoperatively, the mean residual spherical equivalent refractive error was 0.21 diopter G 0.19 (SD). The best corrected distance and near visual acuities were comparable to those before surgery. For distance vision, the safety index was 1.02 and the efficacy index was 0.91. For near vision, the values were 1.04 and 1.02, respectively. There were no statistical…

IqYmune® is an effective maintenance treatment for multifocal motor neuropathy: A randomised, double‐blind, multi‐center cross‐over non‐inferiority s…

2018

Intravenous immunoglobulin (IVIg) is the gold-standard for maintenance treatment of multifocal motor neuropathy (MMN). This phase III, randomised, double-blind, multi-centre, active-control, crossover study, aimed to evaluate the non-inferiority of IqYmune® relative to Kiovig®, primarily based on efficacy criteria. Twenty-two adult MMN patients, treated with any brand of IVIg (except Kiovig® or IqYmune®) at a stable maintenance dose within the range of 1 to 2 g/kg every 4 to 8 weeks, were randomised to receive either Kiovig® followed by IqYmune®, or IqYmune® followed by Kiovig®. Each product was administered for 24 weeks. The primary endpoint was the difference between IqYmune® and Kiovig® …