Search results for "n 3"
showing 10 items of 304 documents
IL-2, IL-3, and IFN-gamma differently affect in vivo frequencies of circulating precursors of cytotoxic T lymphocytes (CTL-p)
1993
Experimental animal and human in vivo studies have previously demonstrated the impact of exogenous administration of various cytokines on frequencies of circulating myeloid and LAK precursor cells. For the first time we investigated whether exogenous cytokines, in the absence of antigenic challenge, may also influence frequencies of circulating antigen-specific cytotoxic T-lymphocyte precursor cells. We further asked whether triggering of autoimmune pathways as has been reported for several cytokines can be confirmed on the cellular level by demonstration of induction of autoreactive CTL-p. Limiting dilution analysis was used to determine alloreactive CTL-p frequencies in 31 patients with n…
Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation
2005
The mechanisms through which regulatory T cells accumulate in lymphoid organs of tumor-bearing hosts remain elusive. Our experiments indicate that the accumulation of CD4+CD25+ regulatory T cells (T reg cells) expressing FoxP3 and exhibiting immunosuppressive function originates from the proliferation of naturally occurring CD25+ T cells and requires signaling through transforming growth factor (TGF)–β receptor II. During tumor progression, a subset of dendritic cells (DCs) exhibiting a myeloid immature phenotype is recruited to draining lymph nodes. This DC subset selectively promotes the proliferation of T reg cells in a TGF-β–dependent manner in mice and rats. Tumor cells are necessary a…
Galectin-3 is a marker of favorable prognosis and a biologically relevant molecule in neuroblastic tumors
2014
Childhood neuroblastic tumors are characterized by heterogeneous clinical courses, ranging from benign ganglioneuroma (GN) to highly lethal neuroblastoma (NB). Although a refined prognostic evaluation and risk stratification of each tumor patient is becoming increasingly essential to personalize treatment options, currently only few biomolecular markers (essentially MYCN amplification, chromosome 11q status and DNA ploidy) are validated for this purpose in neuroblastic tumors. Here we report that Galectin-3 (Gal-3), a β-galactoside-binding lectin involved in multiple biological functions that has already acquired diagnostic relevance in specific clinical settings, is variably expressed in m…
Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity.
2011
SummaryImmunological functions of mast cells remain poorly understood. Studies in Kit mutant mice suggest key roles for mast cells in certain antibody- and T cell-mediated autoimmune diseases. However, Kit mutations affect multiple cell types of both immune and nonimmune origin. Here, we show that targeted insertion of Cre-recombinase into the mast cell carboxypeptidase A3 locus deleted mast cells in connective and mucosal tissues by a genotoxic Trp53-dependent mechanism. Cre-mediated mast cell eradication (Cre-Master) mice had, with the exception of a lack of mast cells and reduced basophils, a normal immune system. Cre-Master mice were refractory to IgE-mediated anaphylaxis, and this defe…
UTILIZACIÓN DE TÉCNICAS DE FOTO-RECONSTRUCCIÓN 3D AUTOMATIZADA EN GEOMORFOLOGÍA: EJEMPLOS PARA DIFERENTES MORFOLOGÍAS Y ESCALAS
2014
Three-dimensional photo-reconstruction methods based on Structure from Motion (SfM) and MultiView-Stereo techniques (MVS) are tested for measuring, monitoring and quantifying three different geomorphological features: i) the Corral del Veleta rock glacier and ii) five small gully headcuts in Spain and iii) Calanchi type badland in Italy. Results about the accuracy, usefulness and applicability of these techniques are presented here. The results of these analyses showed centimeter-level accuracies with average distances to the benchmark models ranging from 0.009 m to 0.42 m.
Antigens expressed by myelinating glia cells induce peripheral cross‐tolerance of endogenous CD8+T cells
2009
Auto-reactivity of T cells is largely prevented by central and peripheral tolerance. Nevertheless, immunization with certain self-antigens emulsified in CFA induces autoimmunity in rodents, suggesting that tolerance to some self-antigens is not robust. To investigate the fate of nervous system-specific CD8(+) T cells, which only recently came up as being important contributors for MS pathogenesis, we developed a mouse model that allows inducible expression of lymphocytic choriomeningitis virus-derived CD8(+) T-cell epitopes specifically in oligodendrocytes and Schwann cells, the myelinating glia of the nervous system. These transgenic CD8(+) T-cell epitopes induced robust tolerance of endog…
Population differences in the International Multi-Centre ADHD Gene Project.
2008
Contains fulltext : 71443.pdf (Publisher’s version ) (Closed access) The International Multi-Centre ADHD Gene sample consists of 674 families from eight countries (Belgium, England, Germany, Holland, Ireland, Israel, Spain, and Switzerland) ascertained from clinics for combined-type attention definity hyperactivity disorder in an offspring. 863 SNPs were successfully genotyped across 47 autosomal genes implicated in psychiatric disorders yielding a single nucleotide polymorphism (SNP) density of approximately one SNP per 2.5 kb. A global test of heterogeneity showed 269 SNPs nominally significant (expected 43). Inclusion of the Israeli population accounted for approximately 70% of these nom…
Editorial: CSF1R, CSF-1, and IL-34, a "menage a trois" conserved across vertebrates.
2010
Abstract Editorial discusses the perspectives opened by the recently discovered IL-34, its conservation across species in the biology of the cytokine CSF-1, and identification of a new CSF-1R ligand that could together account for the well-known heterogeneity of monocytes.
Overionization in X-ray spectra: a new paradigm for Mixed-Morphology SNRs
2011
Mixed-morphology SNRs are characterized by a shell-like radio emission, a centrally peaked X-ray morphology, and by interaction with molecular clouds. Many models have been proposed to explain these peculiar remnants, but their physical origin is still unclear. The recent discovery of over-ionized (i. e. recombining) ejecta in 3 mixed-morphology SNRs has dramatically challenged all the previous models and opened up new, unexpected scenarios. I review the main properties of these remnants and their peculiar X-ray spectral properties. I also discuss the hydrodynamic model developed to explain the presence of over-ionized ejecta in W49B and present a list of open issues that still need to be c…
Crónica de un viaje. Trabajos sobre la arquitectura teatral y la escenificación del teatro del Siglo de Oro
2019
Este artículo describe la trayectoria de un grupo de trabajo dedicado a la investigación del Teatro del Siglo de Oro, especialmente a la arquitectura teatral de los corrales de comedias, a la maquinaria teatral o tramoya de los mismos y la escenificación de los espectáculos. El origen del equipo, trayectorias individuales y singularidad del grupo, ya que no se adscribe a ninguna institución pública. Y que utiliza la documentación filológica, la arquitectura y la reconstrucción virtual como herramientas vinculadas para ofrecer piezas de difusión, análisis y estudio en la materia que nos ocupa This article describes the trajectory of a Work Group dedicated to the investigation of the Golden A…