Search results for "nNOS"
showing 10 items of 219 documents
From Mannose to Small Amphiphilic Polyol: Perfect Linearity Leads To Spontaneous Aggregation
2016
Terminally unsaturated and diastereochemically pure polyol derived from d-mannose shows spontaneous aggregation behavior in water solution. In order to study and clarify this unforeseen phenomenon, a conformational study based on NMR spectroscopy combined with ab initio structure analysis using the COSMO-solvation model was pursued. The results, together with X-ray diffraction studies, suggest a low energy linear conformation for this particular substrate both in solid states and in solution. For such small-sized acyclic carbohydrate derivatives, the linear conformation appears to be a key prerequisite for the unusual molecular self-assembly reported herein. peerReviewed
Semanttinen muunnos
2008
'Immunogenetics of Aging': report on the activities of the 15th International HLA and Immunogenetics Working Group and 15th International HLA and Imm…
2011
'Immunogenetics of Aging' is a component that was first included in the 14th International HLA and Immunogenetics Workshop (IHIWS) and developed further within the 15th Workshop. The aim of this component was to assess the impact of human leukocyte antigen (HLA) genes, cytokine genes, and some innate immunity genes such as killer-cell immunoglobulin-like receptors (KIRs) and mannose-binding lectin 2 (MBL2) in successful aging and their contribution to the better understanding of immune dysfunction in old age. Within the 15th IHIWS new populations were included in the analysis. Additional cytokine gene polymorphisms were assessed and innate immunity genes were analyzed for possible relevance…
"Kyl se on tärkeetä, että nää oppilaat tietää mistä ne on tulleet..." : opettajanäkökulma peruskoulun kulttuuriperintöopetukseen
2001
"Sit mä tajusin, et tonne mä haen" : abiturienttien käsityksiä ammatin- ja koulutusvalinnasta sekä ammatinvalinnanohjauksesta lukiossa
2011
Ammatin- ja koulutusvalintaprosessi on nuorille ajankohtainen asia ensimmäisen kerran jo peruskoulun lopun lähestyessä. Lukion valinneet taas joutuvat pohtimaan ammatinvalinta-asioita perusteellisesti jopa ensimmäiseltä vuosikurssilta lähtien. Nykyään nuorilla on todella paljon vaihtoehtoja ja mahdollisuuksia siihen, mitä he voivat tehdä lukion jälkeen. Halusimmekin tutkia, kuinka abiturientit kokevat tämän elämänvaiheen ja mahdollisuuksien paljouden. Tämän pro gradu -työn tarkoituksena oli selvittää abiturienttien ammatin- ja koulutusvalinnallisia käsityksiä, suunnitelmia ja varmuutta. Selvitimme, mitkä ovat abiturienttien käsityksien mukaan merkittäviä asioita ammatin- ja koulutusvalinnas…
The influence of yeast glycosylated proteins on tannins aggregation in model solution
2004
<p style="text-align: justify;">The incidence of glycosylated yeast proteins on tannins aggregation in model solution was investigated using the spectrophotometric method (absorbance 700 nm). Glycosylated proteins released by two commercial <em>Saccharomyces cerevisiae</em> strains (RC212 and BM 45) during alcoholic fermentation in synthetic media, glycosylated proteins extracted by Peat’s method and industrial glycosylated proteins purified and separated by chromatography on Sepharose Concanavalin A were used to visualize effects on tannins aggregation. Results showed that tannins aggregation was limited by the glycosylated proteins according to their origin and their mod…
The influence of infective dose, nutrient availability and coinfection on virulence of Flavobacterium columnare : implications of intensive aquacultu…
2016
Ecological factors are known to affect disease dynamics and even lead to disease emergence. Especially in opportunistic, environmentally transmitted pathogens, the environment may significantly contribute to pathogen virulence. Intensive farming, including aquaculture, has been suggested to create conditions favouring development of highly virulent pathogens. At Finnish fish farms, epidemics caused by opportunistic Flavobacterium columnare have been constantly increasing in their prevalence and severity since the 1980’s. Yet, factors behind the increased virulence of the pathogen and their mechanisms of action have largely remained unsolved. In this thesis, I explore the effects of infectio…
First report of Cotoneaster pannosus Franch. (Rosaceae) in Tarragona Province, and updated distribution area in Spain
2015
8 p., il., mapas
Improved synthesis and application of conjugation-amenable polyols from d-mannose
2019
A series of polyhydroxyl sulfides and triazoles was prepared by reacting allyl and propargyl d-mannose derivatives with selected thiols and azides in thiol-ene and Huisgen click reactions. Conformational analysis by NMR spectroscopy proved that the intrinsic rigidity and linear conformation of the mannose derived polyol backbone is retained in the final click products in solution. Single crystal X-ray structure determination of one of the compounds prepared further verified that the linear conformation of the polyol segment is also retained in the solid state. In addition, an improved method for direct Barbier-type propargylation of unprotected d-mannose is reported. The new reaction protoc…