Search results for "nap"

Rats bred for low intrinsic aerobic exercise capacity link obesity with brain inflammation and reduced structural plasticity of the hippocampus.

2021

Abstract BACKGROUND Increasing evidence shows obesity and poor metabolic health are associated with cognitive deficits, but the mechanistic connections have yet to be resolved. We studied rats selectively bred for low and high intrinsic aerobic capacity in order to test the association between low physical fitness, a genetic predisposition for obesity, and brain health. We hypothesized that low-capacity runner (LCR) rats with concurrently greater levels of adiposity would have increased hippocampal inflammation and reduced plasticity compared to the more physically fit high-capacity runner (HCR) rats. METHODS We examined markers for inflammation and brain plasticity in the hippocampi of LCR…

"Onneksi olen Emma ja minä olen laiha kaunis nainen" : pronominivariaatio koodinvaihdon keinona pelivideoissa

2017

Tutkielmassa on pyritty selvittämään, millä persoonapronomineilla eräs suomalainen Let’s Play -videoiden tekijä viittaa itseensä videoissaan ja kuinka nämä pronominit varioivat eli mitä eri variantteja (mä, mie ym.) niistä käytetään ja missä tilanteissa. Erityisesti on kiinnitetty huomiota yksikön 1. persoonan pronominin yleiskieliseen varianttiin minä ja sen käyttötapoihin. Diskurssintutkimuksen näkökulmasta on pohdittu, mitä pronominivalinnoilla tavoitellaan pelivideoissa. Aineistona on käytetty kolmea YouTubessa julkaistua pelivideota, jotka on litteroitu. Tutkielman aihe on ajankohtainen, koska pelivideot ovat viime vuosina saavuttaneet laajan suosion. Suomalaisia pelivideoita on tutkit…

Welfare regimes and labour market integration policies in Europe

2023

This chapter discusses migrant labour market integration policies and services in the Czech Republic, Denmark, Greece, Finland, Italy, Switzerland and the United Kingdom, and thus we present a wide variety of different national contexts. In addition, it also details EU-specific policies and programmes. The empirical work underpinning this chapter emanates from two main research tasks: policy discourse analysis; and assessment of existing policies and their outcomes. A policy discourse analysis was conducted across the selected countries to identify and analyse how issues of labour market integration are discussed by policymakers and policy actors. By analysing the findings of the discourse …

Zur pronominalen Anrede im Roman 'Kuolemanspiraali' und seiner deutschsprachigen Übersetzung 'Die Todesspirale'

2008

Inappropriateness in laboratory medicine: an elephant in the room?

2017

Appropriateness of diagnostic testing can be conventionally described as prescription of the right test, using the right method, at the right time, to the right patient, with the right costs and for producing the right outcome. There is ongoing debate about the real burden of inappropriateness in laboratory diagnostics. The media coverage of this issue has also recently led to either over- or under-emphasizing the clinical, organizational and economic consequences. This is quite problematic, inasmuch as some reliable data are available in the current scientific literature, showing that inappropriateness of laboratory testing can be as high as 70%. This is especially evident for, though not …

Lasten ja nuorten oikeudet oppimiseen ja hyvinvointiin vaarantuivat koronapandemian aikana

2023

• Lasten ja nuorten oppimiseen ja hyvinvointiin liittyvät oikeudet vaarantuivat korona-aikana. • Osa lapsista ja nuorista ei saanut tarvitsemaansa ja toivomaansa tukea. • Lasten ja nuorten väliset erot hyvinvoinnissa kasvoivat. • Korona-aika lisäsi lasten ja nuorten yksinäisyyden kokemuksia. • Tulevissa etäopetustilanteissa tulisi huolehtia siitä, että lasten ja nuorten hyvinvointia ja yhteenkuuluvuuden tunnetta tuetaan vahvemmin. nonPeerReviewed

The Eminent French Chemist Claude-Louis Berthollet (1748-1822) in the Literature between the 19th and 21st Century

2020

Claude-Louis Berthollet (1748-1822) was one of the greatest French chemists of the eighteenth and the first 20 years of the nineteenth century. His life and scientific achievements were described in the literature published between the 19th and 21st centuries in different countries. The purpose of this article was to familiarize readers with the important events in the life of C.-L. Berthollet and his research activities, in particular some of his experimental research results, as well as his selected publications. In addition, the names of authors of biographies or biographical notes about Claude-Louis Berthollet, published in 1823-2018 were presented.

NPM-ALK-reactive T-cell responses in children and adolescents with NPM-ALK positive anaplastic large cell lymphoma

2019

ABSTRACT The oncoantigen nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces cellular and humoral immune responses in patients with NPM-ALK-positive anaplastic large cell lymphoma (ALCL). We characterize the NPM-ALK-specific T-cell responses in a cohort of pediatric and adolescent ALCL-patients in remission without Human Leucocyte Antigen (HLA)-preselection. First, we assessed NPM-ALK-reactive T-cell responses and their HLA-class I restriction in patients by using dendritic cells (DCs) transfected with in vitro transcribed (IVT) NPM-ALK-RNA for CD8 (n = 20) or CD3 (n = 9) T-cell stimulation. NPM-ALK-specific T-cells were detected in twelve of 29 patients (nine of 20 with CD8-selected…

Interleukin 10 restores lipopolysaccharide-induced alterations in synaptic plasticity probed by repetitive magnetic stimulation

2020

Systemic inflammation is associated with alterations in complex brain functions such as learning and memory. However, diagnostic approaches to functionally assess and quantify inflammation-associated alterations in synaptic plasticity are not well-established. In previous work, we demonstrated that bacterial lipopolysaccharide (LPS)-induced systemic inflammation alters the ability of hippocampal neurons to express synaptic plasticity, i.e., the long-term potentiation (LTP) of excitatory neurotransmission. Here, we tested whether synaptic plasticity induced by repetitive magnetic stimulation (rMS), a non-invasive brain stimulation technique used in clinical practice, is affected by LPS-induc…

New Insight into Immunity and Immunopathology of Rickettsial Diseases

2011

Human rickettsial diseases comprise a variety of clinical entities caused by microorganisms belonging to the generaRickettsia,Orientia,Ehrlichia, andAnaplasma. These microorganisms are characterized by a strictly intracellular location which has, for long, impaired their detailed study. In this paper, the critical steps taken by these microorganisms to play their pathogenic roles are discussed in detail on the basis of recent advances in our understanding of molecularRickettsia-host interactions, preferential target cells, virulence mechanisms, three-dimensional structures of bacteria effector proteins, upstream signalling pathways and signal transduction systems, and modulation of gene exp…